Tématerületi Kiválósági Program 2021 - Transzlációs biomedicina(TKP2021-EGA-28) Támogató:
NKFIH
(TKP2021-EGA-32) Támogató: NKFIH
Pancreatic cancer (PC) poses a substantial global health challenge, ranking as the
fourth leading cause of cancer-related deaths due to its high mortality rate. Late-stage
diagnoses are common due to the absence of specific symptoms. Pancreatic ductal adenocarcinoma
(PDAC) accounts for the majority of PC cases. Recent research has suggested a potential
link between elevated serum levels of bile acids (BAs) and tumorigenesis of PDAC.
This study aims to understand how taurochenodeoxycholic acid (TCDCA), a secondary
BA, influences PDAC using RNA sequencing techniques on the Capan-1 cell line. We identified
2,950 differentially expressed genes (DEGs) following TCDCA treatment, with 1,597
upregulated and 1,353 downregulated genes. These DEGs were associated with critical
PDAC pathways, including coagulation, angiogenesis, cell migration, and signaling
regulation. Furthermore, we reviewed relevant literature highlighting genes like DKK-1,
KRT80, UPLA, and SerpinB2, known for their roles in PDAC tumorigenesis and metastasis.
Our study sheds light on the complex relationship between BAs and PDAC, offering insights
into potential diagnostic markers and therapeutic targets. Further research is needed
to unravel these findings' precise mechanisms and clinical implications, potentially
improving PDAC diagnosis and treatment.
