https://m2.mtmt.hu/ hun 2026-05-25 04:18 JournalArticle 34878184 VALIDATED true * Megosztott szerzőség 0 false 2026-05-23T20:51:50.196+0000 2024-09-13T13:20:51.812+0000 2024-05-27T08:00:35.407+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2024-09-18T11:28:48.369+0000 2024-09-13T13:20:51.908+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:24.083+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sanvicente García, Adrián Clinical and Immunologic Characteristics of Colorectal Cancer Tumors Expressing LY6G6D. true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 10 5345 5345 11 2024 The identification of targets that are expressed on the cell membrane is a main goal in cancer research. The Lymphocyte Antigen 6 Family Member G6D (LY6G6D) gene codes for a protein that is mainly present on the surface of colorectal cancer (CRC) cells. Therapeutic strategies against this protein like the development of T cell engagers (TCE) are currently in the early clinical stage. In the present work, we interrogated public genomic datasets including TCGA to evaluate the genomic and immunologic cell profile present in tumors with high expression of LY6G6D. We used data from TCGA, among others, and the Tumor Immune Estimation Resource (TIMER2.0) platform for immune cell estimations and Spearman correlation tests. LY6G6D expression was exclusively present in CRC, particularly in the microsatellite stable (MSS) subtype, and was associated with left-side tumors and the canonical genomic subgroup. Tumors with mutations of APC and p53 expressed elevated levels of LY6G6D. This protein was expressed in tumors with an inert immune microenvironment with an absence of immune cells and co-inhibitory molecules. In conclusion, we described clinical, genomic and immune-pathologic characteristics that can be used to optimize the clinical development of agents against this target. Future studies should be performed to confirm these findings and potentially explore the suggested clinical development options. true INTERNATIONAL 2024 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms25105345 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 D1 false false false false 2024-05-26T12:50:33.898+0000 Biofizikai Intézet (PTE / ÁOK); Bioinformatika Tanszék (SE / AOK / I); Enzimológiai Intézet (TTK); Gyermekgyógyászati Klinika (SE / AOK / K) 2 28 4 11 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116786988 /api/authorship/116786988 1 0.09090909 true false false Sanvicente García Adrián true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786989 /api/authorship/116786989 2 0.091 true false false Pedregal Manuel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786990 /api/authorship/116786990 3 0.09090909 false false false Paniagua-Herranz Lucía true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786991 /api/authorship/116786991 4 0.09090909 false false false Díaz-Tejeiro Cristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786992 /api/authorship/116786992 5 0.09090909 false false false Nieto-Jiménez Cristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786993 /api/authorship/116786993 6 0.09090909 false false false Pérez Segura Pedro true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786994 /api/authorship/116786994 7 0.091 false false false Author 10024232 /api/author/10024232 Munkácsy Gyöngyi true 10024232 true Munkácsy Gyöngyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786995 /api/authorship/116786995 8 0.091 false false false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786996 /api/authorship/116786996 9 0.09090909 false false false Calvo Emiliano true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786997 /api/authorship/116786997 10 0.09090909 false false false Moreno Víctor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116786998 /api/authorship/116786998 11 0.091 false true true Ocaña Alberto true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26245808 /api/publicationidentifier/26245808 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25105345 https://doi.org/10.3390/ijms25105345 false true PublicationIdentifier 26313394 /api/publicationidentifier/26313394 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001232617200001 https://www.webofscience.com/wos/woscc/full-record/001232617200001 true true PublicationIdentifier 26313369 /api/publicationidentifier/26313369 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85194218531 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85194218531 true true PublicationIdentifier 26245807 /api/publicationidentifier/26245807 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38791382 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38791382&dopt=Abstract false true Keyword 1159223 /api/keyword/1159223 true 1159223 true Keyword 2070090 /api/keyword/2070090 true true Keyword 3386687 /api/keyword/3386687 true true Keyword 3386688 /api/keyword/3386688 true true SjrRating 11489344 /api/sjrrating/11489344 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 true 1605 true D1 DIRECT true true /api/publication/34878184 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Sanvicente García Adrián </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pedregal Manuel<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Paniagua-Herranz Lucía </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Díaz-Tejeiro Cristina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nieto-Jiménez Cristina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pérez Segura Pedro </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024232"><a href="/gui2/?type=authors&mode=browse&sel=10024232" target="_blank">Munkácsy Gyöngyi (<span class="authorship-author-name">Munkácsy Gyöngyi</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Calvo Emiliano </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moreno Víctor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ocaña Alberto ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34878184" target="_blank">Clinical and Immunologic Characteristics of Colorectal Cancer Tumors Expressing LY6G6D.</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">10</span> <span class="page"> Paper 5345. 11 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25105345" target="_blank" href="https://doi.org/10.3390/ijms25105345"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001232617200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001232617200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85194218531" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85194218531"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38791382" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38791382&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34878184&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34878184</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.09.13. 15:20 Berhidi Anna (SE_KK_Admin5_BA, admin) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:27 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>