https://m2.mtmt.hu/ hun 2026-09-22 13:38 JournalArticle 34861047 VALIDATED true 0 false 2026-05-23T20:08:43.319+0000 2024-05-17T06:54:37.090+0000 2024-05-17T06:47:47.361+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-07-07T13:05:28.873+0000 2025-07-07T13:05:28.873+0000 2024-05-17T06:54:37.104+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kovacs, Peter Perturbing cortical networks: in vivo electrophysiological consequences of pan-neuronal chemogenetic manipulations using deschloroclozapine true true /api/journal/39990 REVIEWED true false 39990 false 39990 true 1662-4548 1662-453X Journal FOREIGN 18 1396978 1396978 15 2024 Introduction: Chemogenetic techniques, specifically the use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), have become invaluable tools in neuroscience research. Yet, the understanding of how Gq- and Gicoupled DREADDs alter local field potential (LFP) oscillations in vivo remains incomplete. Methods: This study investigates the in vivo electrophysiological effects of DREADD actuation by deschloroclozapine, on spontaneous firing rate and LFP oscillations recorded from the anterior cingulate cortex in lightly anesthetized male rats. Results: Unexpectedly, in response to the administration of deschloroclozapine, we observed inhibitory effects with pan-neuronal hM3D(Gq) stimulation, and excitatory effects with pan-neuronal hM4D(Gi) stimulation in a significant portion of neurons. These results emphasize the need to account for indirect perturbation effects at the local neuronal network level in vivo, particularly when not all neurons express the chemogenetic receptors uniformly. In the current study, for instance, the majority of cells that were transduced with both hM3D(Gq) and hM4D(Gi) were GABAergic. Moreover, we found that panneuronal cortical chemogenetic modulation can profoundly alter oscillatory neuronal activity, presenting a potential research tool or therapeutic strategy in several neuropsychiatric models and diseases. Discussion: These findings help to optimize the use of chemogenetic techniques in neuroscience research and open new possibilities for novel therapeutic strategies. 2024 true true true false false GOLD 2026-05-23 false http://www.frontiersin.org/neuroscience 1 0 1 1 0 1 1 1 0 1 1 1 1 1 0 0 1 1 1 1 0 1 1 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q2 false false false false 2024-05-16T06:54:36.944+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 1 5 1 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116631636 /api/authorship/116631636 1 0.333 true false true Author 10090209 /api/author/10090209 Kovács Péter true true Kovacs Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116631637 /api/authorship/116631637 2 0.33333334 false false true Beloate Lauren N. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116631638 /api/authorship/116631638 3 0.33333334 false true false Zhang Nanyin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26198711 /api/publicationidentifier/26198711 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3389/fnins.2024.1396978 https://doi.org/10.3389/fnins.2024.1396978 false true PublicationIdentifier 26198712 /api/publicationidentifier/26198712 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001215927100001 https://www.webofscience.com/wos/woscc/full-record/001215927100001 false true PublicationIdentifier 26198714 /api/publicationidentifier/26198714 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85192353454 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192353454 false true PublicationIdentifier 26198713 /api/publicationidentifier/26198713 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38726028 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38726028&dopt=Abstract false true Keyword 1528 /api/keyword/1528 true 1528 true Keyword 6434 /api/keyword/6434 true 6434 true Keyword 1299247 /api/keyword/1299247 true 1299247 true Keyword 1514439 /api/keyword/1514439 true true Keyword 1519716 /api/keyword/1519716 true true Keyword 1547726 /api/keyword/1547726 true true Keyword 2789605 /api/keyword/2789605 true true Keyword 3383263 /api/keyword/3383263 true true Keyword 3383264 /api/keyword/3383264 true true Keyword 3383265 /api/keyword/3383265 true true SjrRating 11487525 /api/sjrrating/11487525 56 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q2 DIRECT true true /api/publication/34861047 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10090209"><a href="/gui2/?type=authors&mode=browse&sel=10090209" target="_blank">Kovacs Peter ✉ (<span class="authorship-author-name">Kovács Péter</span> <span class="authorAux-mtmt"> neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Beloate Lauren N. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhang Nanyin </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34861047" target="_blank">Perturbing cortical networks: in vivo electrophysiological consequences of pan-neuronal chemogenetic manipulations using deschloroclozapine</a></div> <div> <span class="journal-title">FRONTIERS IN NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-4548">1662-4548</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-453X">1662-453X</a>)</span>: <span class="journal-volume">18</span> <span class="page"> Paper 1396978. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fnins.2024.1396978" target="_blank" href="https://doi.org/10.3389/fnins.2024.1396978"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001215927100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001215927100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85192353454" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192353454"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38726028" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38726028&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34861047&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34861047</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2024.05.17. 08:54 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>