https://m2.mtmt.hu/ hun 2026-03-05 12:46 JournalArticle 34840271 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program (National Tumor Biology Laboratory) [2022-2.1.1-NL-2022-00010]; Hungarian Thematic Excellence Program [TKP2021-EGA-44]; National Research, Development and Innovation Office [2020-1.1.6-JOVO -2021-00003, 2020-1.1.6-JOVO -2021-00008, NKFIH-FK-142877, NKFIH-FK-138377]; Janos Bolyai Postdoctoral Scholarship [BO/00582/22/8, BO/00141/21]; New National Excellence Program Bolyai+ Scholarship [UNKP-23-5-SZTE-694, UNKP-22-5-SE-25]; COST Action [CA20122] Funding text: The project was implemented with the support from the National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program (National Tumor Biology Laboratory (2022-2.1.1-NL-2022-00010) ) and the Hungarian Thematic Excellence Program (under project TKP2021-EGA-44) Grant Agreements with the National Research, Development and Innovation Office. The authors would like to acknowledge the financial support of the National Research, Development and Innovation Office under grants Investment into Future (2020-1.1.6-JOVO -2021-00003 and 2020-1.1.6-JOVO -2021-00008) , NKFIH-FK-142877, and NKFIH-FK-138377. G.J.S. is the recipient of the Janos Bolyai Postdoctoral Scholarship (BO/00582/22/8) and the New National Excellence Program Bolyai+ Scholarship (UNKP-23-5-SZTE-694) . V.K.G. is the recipient of the Janos Bolyai Postdoctoral Scholarship (BO/00141/21) and the New National Excellence Program Bolyai+ Scholarship (UNKP-22-5-SE-25, UNKP-23-5-SE-16) . V.K.G. is supported by COST Action CA20122 Harmonisation. 0 false 2026-03-05T10:49:13.977+0000 2025-04-14T10:21:36.432+0000 2024-05-07T07:08:56.116+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin true 10045852 2025-04-14T10:15:59.473+0000 2025-04-14T10:15:59.473+0000 2025-04-14T10:21:36.718+0000 true 10058176 Nagyné Tari Emese /api/admin/10058176 Admin true 10058176 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2025-04-30T11:24:44.862+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Balog, József Ágoston Peripheral immunophenotyping reveals lymphocyte stimulation in healthy women living with hereditary breast and ovarian cancer syndrome true true /api/journal/10088725 REVIEWED true false 10088725 false 10088725 true 2589-0042 Journal FOREIGN 27 6 109882 109882 15 2024 Germline pathogenic variants in BRCA1 and BRCA2 (gpath(BRCA1/2)) represent genetic susceptibility for hereditary breast and ovarian cancer syndrome. Tumor-immune interactions are key contributors to breast cancer pathogenesis. Although earlier studies confirmed pro-tumorigenic immunological alterations in breast cancer patients, data are lacking in healthy carriers of gpath(BRCA1/2). Peripheral blood mononuclear cells of 66 women with or without germline predisposition or breast cancer were studied with a mass cytometry panel that identified 4 immune subpopulations of altered frequencies between healthy controls and healthy gpath(BRCA1) carriers, while no difference was observed in healthy gpath(BRCA2) carriers compared to controls. Moreover, 3 (one IgD-CD27+CD95+ B cell subpopulation and two CD45RA-CCR7+CD38+ CD4+ T cell subpopulations) out of these 4 subpopulations were also elevated in triple-negative breast cancer patients compared to controls. Our results reveal an activated peripheral immune phenotype in healthy carriers of gpath(BRCA1) that needs to be further elucidated to be leveraged in risk-reducing strategies. 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10065273"><a href="/gui2/?type=authors&mode=browse&sel=10065273" target="_blank">Balog József Ágoston (<span class="authorship-author-name">Balog József Ágoston</span> <span class="authorAux-mtmt"> immunológia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Szegedi Biológiai Kutatóközpont">HRN SZBK</span>/Genetikai Intézet; <span title="HUN-REN Szegedi Biológiai Kutatóközpont">HRN SZBK</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085324"><a href="/gui2/?type=authors&mode=browse&sel=10085324" target="_blank">Horti-Oravecz Klaudia<sup>*</sup> (<span class="authorship-author-name">Horti-Oravecz Klaudia</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020807"><a href="/gui2/?type=authors&mode=browse&sel=10020807" target="_blank">Kövesdi Dorottya (<span class="authorship-author-name">Kövesdi Dorottya</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040748"><a href="/gui2/?type=authors&mode=browse&sel=10040748" target="_blank">Bozsik Anikó (<span class="authorship-author-name">Bozsik Anikó</span> <span class="authorAux-mtmt"> Molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/HUN-REN-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040551"><a href="/gui2/?type=authors&mode=browse&sel=10040551" target="_blank">Papp Janos (<span class="authorship-author-name">Papp János</span> <span class="authorAux-mtmt"> molekuláris genetika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020420"><a href="/gui2/?type=authors&mode=browse&sel=10020420" target="_blank">Butz Henriett (<span class="authorship-author-name">Butz Henriett</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/HUN-REN-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001006"><a href="/gui2/?type=authors&mode=browse&sel=10001006" target="_blank">Patócs Attila (<span class="authorship-author-name">Patócs Attila Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/HUN-REN-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025339"><a href="/gui2/?type=authors&mode=browse&sel=10025339" target="_blank">Szebeni Gábor János<sup>**</sup> ✉ (<span class="authorship-author-name">Szebeni Gábor</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Szegedi Biológiai Kutatóközpont">HRN SZBK</span>/Genetikai Intézet; <span title="HUN-REN Szegedi Biológiai Kutatóközpont">HRN SZBK</span>/Központi Laboratóriumok; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Belgyógyászati Klinika">BK</span>/II. sz. Belgyógyászati Klinika és Kardiológiai Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032280"><a href="/gui2/?type=authors&mode=browse&sel=10032280" target="_blank">Grolmusz Vince Kornél ✉ (<span class="authorship-author-name">Grolmusz Vince Kornél</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/HUN-REN-SE Örökletes Daganatok Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34840271" target="_blank">Peripheral immunophenotyping reveals lymphocyte stimulation in healthy women living with hereditary breast and ovarian cancer syndrome</a></div> <div> <span class="journal-title">ISCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2589-0042">2589-0042</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">6</span> <span class="page"> Paper 109882. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.isci.2024.109882" target="_blank" href="https://doi.org/10.1016/j.isci.2024.109882"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001292490900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001292490900001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="204267" target="_blank" href="http://real.mtak.hu/204267"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85192900784" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192900784"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38799565" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38799565&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="36495" target="_blank" href="http://publicatio.bibl.u-szeged.hu/36495"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 0 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34840271&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34840271</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> ((2022–2.1.1-NL-2022-00010)), Hungarian Thematic Excellence Program((TKP2021-EGA-44)), (2020-1.1.6-JÖVŐ-2021-00003) Támogató: NKFIH, (2020-1.1.6-JÖVŐ-2021-00008), (FK22-142877), (138377) Támogató: NKFIH, (BO/00582/22/8), (János Bolyai Postdoctoral Scholarship (BO/00141/21)), Kulturális és Innovációs Minisztérium Új Nemzeti Kiválósági Ösztöndíja(ÚNKP-22-5-SE-25) Támogató: Kulturális és Innovációs Minisztérium, (ÚNKP-23-5-SE-16) </div> <div class="lastModified">Utolsó módosítás: 2025.04.14. 12:21 Nagyné Tari Emese (SZTE admin5) </div> <div class="lockedBy">Központi kezelésű 2025.04.30. 13:24 Vándor Andrea (VA, admin) Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program (National Tumor Biology Laboratory) [2022-2.1.1-NL-2022-00010]; Hungarian Thematic Excellence Program [TKP2021-EGA-44]; National Research, Development and Innovation Office [2020-1.1.6-JOVO -2021-00003, 2020-1.1.6-JOVO -2021-00008,...</pre> </div></div>