https://m2.mtmt.hu/ eng 2026-05-01 20:54 JournalArticle 34827132 VALIDATED true Royal Cornwall Hospital, Treliske, Truro, United Kingdom AOU delle Marche, Università Politecnica delle Marche, Ancona, Italy Instituto Valenciano de Oncología, Valencia, Spain Kingston Health Sciences Centre, Kingston, ON, Canada NU Cancer, Newcastle University, Newcastle upon Tyne, United Kingdom St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia Sarah Cannon Research Institute, HCA Healthcare, London, United Kingdom National Institute of Oncology, Budapest, Hungary Clinic Institute of Hematological and Oncological Diseases, Hospital Clinic, Barcelona, Spain Hospital Universitario 12 de Octubre, Madrid, Spain Weston Park Hospital, University of Sheffield, Sheffield, United Kingdom General University Hospital in Prague, Prague, Czech Republic IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori,”, Meldola, Italy Pfizer, San Francisco, CA, United States Pfizer, San Diego, CA, United States Pfizer, New York, NY, United States Pfizer, Paris, France Pfizer, Milan, Italy Fundación Jiménez Díaz University Hospital, Madrid, Spain Export Date: 15 January 2025 Correspondence Address: Wheatley, D.A.; Royal Cornwall Hospital, Treliske, United Kingdom; email: duncanwheatley@nhs.net Chemicals/CAS: avelumab, 1537032-82-8; carboplatin, 41575-94-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; doxecitine, 951-77-9, 56905-41-0; gemcitabine, 103882-84-4, 95058-81-4; pemetrexed, 137281-23-3, 150399-23-8, 357166-30-4, 357166-29-1; Antibodies, Monoclonal, Humanized; avelumab; Carboplatin; Cisplatin; Deoxycytidine; Gemcitabine; Pemetrexed 0 false 2026-01-01T16:31:54.270+0000 2025-01-15T13:48:13.623+0000 2024-04-30T05:52:35.992+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2025-03-20T09:39:42.369+0000 2025-01-15T13:48:13.789+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2025-03-13T00:09:46.701+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Wheatley, Duncan A First-line avelumab plus chemotherapy in patients with advanced solid tumors results from the phase 1b/2 JAVELIN Chemotherapy Medley study. true true /api/journal/20113812 REVIEWED true false false 20113812 true 2767-9764 Journal FOREIGN 4 6 1609 1619 1609 11 2024 Chemotherapy can potentially enhance the activity of immune checkpoint inhibitors by promoting immune priming. The phase 1b/2 JAVELIN Chemotherapy Medley trial evaluated first-line avelumab + concurrent chemotherapy in patients with advanced urothelial carcinoma or nonsmall cell lung cancer (NSCLC).Avelumab 800 mg or 1200 mg was administered continuously every 3 weeks (Q3W) with standard doses of cisplatin + gemcitabine in patients with urothelial carcinoma, or carboplatin + pemetrexed in patients with nonsquamous NSCLC. Dual primary endpoints were dose-limiting toxicity (DLT; phase 1b) and confirmed objective response (phase 1b/2).In phase 1b, urothelial carcinoma and NSCLC cohorts received avelumab 800 mg (n=13 and n=6, respectively) or 1200 mg (n=6 each) + chemotherapy. In evaluable patients with urothelial carcinoma treated with avelumab 800 mg or 1200 mg + chemotherapy, DLT occurred in 1/12 (8.3%) and 1/6 (16.7%), respectively; no DLT occurred in the NSCLC cohort. In phase 2, 35 additional patients with urothelial carcinoma received avelumab 1200 mg + chemotherapy. Across all treated patients, safety profiles were similar irrespective of avelumab dose. Objective response rates (95% confidence internal) with avelumab 800 mg or 1200 mg + chemotherapy, respectively, across phase 1b/2, were 53.8% (25.1-80.8) and 39.0% (24.2-55.5) in urothelial carcinoma, and 50.0% (11.8-88.2) and 33.3% (4.3-77.7) in NSCLC.Preliminary efficacy and safety findings with avelumab + chemotherapy in urothelial carcinoma and NSCLC were consistent with previous studies of similar combination regimens. Conclusions about clinical activity are limited by small patient numbers.gov identifier, NCT03317496. true 2024 true true true false true false GOLD 2026-01-01 false https://aacrjournals.org/cancerrescommun 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 Q1 false 10034949 false false false 2024-07-29T05:54:55.553+0000 Országos Onkológiai Intézet 1 5 1 20 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116438601 /api/authorship/116438601 1 0.05 true false false Wheatley Duncan A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438602 /api/authorship/116438602 2 0.05 false false false Berardi Rossana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438603 /api/authorship/116438603 3 0.05 false false false Climent Duran Miguel A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438604 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Garcia-Corbacho Javier true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438610 /api/authorship/116438610 10 0.05 false false false Paz-Ares Luis G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438611 /api/authorship/116438611 11 0.05 false false false Hussain Syed A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438612 /api/authorship/116438612 12 0.05 false false false Petruželka Lubos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438613 /api/authorship/116438613 13 0.05 false false false Delmonte Angelo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116438614 /api/authorship/116438614 14 0.05 false false false Chappey Colombe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Wheatley Duncan A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Berardi Rossana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Climent Duran Miguel A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tomiak Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Greystoke Alastair P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Joshua Anthony M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Arkenau Hendrik-Tobias </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034949"><a href="/gui2/?type=authors&mode=browse&sel=10034949" target="_blank">Géczi Lajos (<span class="authorship-author-name">Géczi Lajos</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">National Institute of Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Corbacho Javier </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Paz-Ares Luis G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hussain Syed A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Petruželka Lubos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Delmonte Angelo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chappey Colombe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Masters Joanna C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Michelon Elisabete </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murphy Danielle A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mwewa Sandrine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cesari Rossano </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doger de Speville Bernard </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34827132" target="_blank">First-line avelumab plus chemotherapy in patients with advanced solid tumors : results from the phase 1b/2 JAVELIN Chemotherapy Medley study..</a></div> <div> <span class="journal-title">CANCER RESEARCH COMMUNICATIONS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2767-9764">2767-9764</a>)</span>: <span class="journal-volume">4</span> <span class="journal-issue">6</span> <span class="page"> pp 1609-1619 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1158/2767-9764.CRC-23-0459" target="_blank" href="https://doi.org/10.1158/2767-9764.CRC-23-0459"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001321759000003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001321759000003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85197353854" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85197353854"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38669053" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38669053&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34827132&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34827132</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.01.15. 14:48 Orsolya Nádas (OOI admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Royal Cornwall Hospital, Treliske, Truro, United Kingdom AOU delle Marche, Università Politecnica delle Marche, Ancona, Italy Instituto Valenciano de Oncología, Valencia, Spain Kingston Health Sciences Centre, Kingston, ON, Canada NU Cancer, Newcastle University, Newcastle upon Tyne, United Kingdom ...</pre> </div></div>