https://m2.mtmt.hu/ hun 2026-05-25 07:46 JournalArticle 34825015 VALIDATED true Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral College/Department of Public Health, Semmelweis University, Budapest, Hungary Department of Public Health, Semmelweis University, Semmelweis University, Budapest, Hungary Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy Dept. of Bioinformatics, Semmelweis University, Budapest, 1094, Hungary Dept. of Biophysics, Medical School, University of Pecs, Pecs, 7624, Hungary Cancer Biomarker Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary Cited By :6 Export Date: 17 February 2025 Correspondence Address: Ungvari, A.; Department of Public Health, Hungary; email: Ungann2004@gmail.com Chemicals/CAS: Biomarkers, Tumor Funding details: Presbyterian Health Foundation, PHF Funding details: National Institute of General Medical Sciences, NIGMS Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Richard S. Reynolds Foundation Funding details: P30AG050911 Funding details: Oklahoma Tobacco Settlement Endowment Trust, TSET, TKP2021-NKTA-47 Funding details: Oklahoma Tobacco Settlement Endowment Trust, TSET Funding details: National Cancer Institute, NCI, P30 CA225520, R01CA255840 Funding details: National Cancer Institute, NCI Funding details: U54GM104938 Funding details: 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019–1 Funding details: P20GM125528 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS100782 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding details: National Institute on Aging, NIA, R01AG068295, R01AG070915, RF1AG072295, R01AG055395 Funding details: National Institute on Aging, NIA Funding details: 135784, RRF-2.3.1–21-2022–00003 Funding text 1: Open access funding provided by Semmelweis University. This work was supported by grants from the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915), the National Institute of Neurological Disorders and Stroke (R01NS100782), the National Cancer Institute (R01CA255840), the Oklahoma Shared Clinical and Translational Resources (U54GM104938) with an Institutional Development Award (IDeA) from NIGMS, the Presbyterian Health Foundation, the Reynolds Foundation, the Oklahoma Nathan Shock Center (P30AG050911), and the Cellular and Molecular GeroScience CoBRE (P20GM125528), the NCI Cancer Center Support Grant (P30 CA225520) and the Oklahoma Tobacco Settlement Endowment Trust. Project no. TKP2021-NKTA-47, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NKTA funding scheme; by funding through the National Cardiovascular Laboratory Program (RRF-2.3.1\\u201321-2022\\u201300003) provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund; Project no. 135784 implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the K_20 funding scheme and the European University for Well-Being (EUniWell) program (grant agreement number: 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019\\u20131). The funding sources had no role in the writing of the manuscript and in the decision to submit the article for publication. The 4.0 version of ChatGPT, developed by OpenAI, and Gemini, developed by Google, were used as a tool to refine our writing and enhance the clarity of our work. The authors acknowledge the support of ELIXIR Hungary ( https://www.bioinformatics.hu/ ). 0 false 2026-05-23T18:53:47.629+0000 2024-11-28T06:12:03.415+0000 2024-04-29T08:27:08.037+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-08-25T12:35:00.871+0000 2024-11-28T06:12:03.648+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:17.278+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ungvari, Zoltan Prognostic significance of a signature based on senescence-related genes in colorectal cancer true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 46 5 4495 4504 4495 10 2024 Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, a DNA damage-induced cellular stress response, is characterized by cell cycle arrest, the expression of an inflammatory senescence-associated secretory phenotype, and alterations in extracellular matrix metabolism. It is widely recognized as a fundamental and evolutionarily conserved mechanism of aging. Guided by geroscience principles, which assert that the pathogenesis of age-related diseases involves cellular mechanisms of aging, this study delves into the role of senescence-related genes in colon cancer progression. Leveraging a gene set reflective of senescence-associated pathways, we employed uni- and multivariate Cox proportional hazards survival analysis combined with the determination of the false discovery rate to analyze correlations between gene expression and survival. The integrated database of 1130 colon cancer specimens with available relapse-free survival time and relapse event data from ten independent cohorts provided a robust platform for survival analyses. We identified senescence-related genes associated with differential expression levels linked to shorter survival. Our findings unveil a prognostic signature utilizing cellular senescence-related genes (hazard ratio: 2.73, 95% CI 2.12-3.52, p = 6.4E - 16), offering valuable insights into survival prediction in colon cancer. Multivariate analysis underscored the independence of the senescence-related signature from available epidemiological and pathological variables. This study highlights the potential of senescence-related genes as prognostic biomarkers. Overall, our results underscore the pivotal role of cellular senescence, a fundamental mechanism of aging, in colon cancer progression. 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Bioinformatika Tanszék (SE / AOK / I); Doktori Iskola (SE); Népegészségtani Intézet (SE / AOK / I); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 3 46 5 4 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116416725 /api/authorship/116416725 1 0.25 true false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116416726 /api/authorship/116416726 2 0.25 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116416727 /api/authorship/116416727 3 0.25 false false false Bianchini Giampaolo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116416728 /api/authorship/116416728 4 0.25 false true false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26099325 /api/publicationidentifier/26099325 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s11357-024-01164-6 https://doi.org/10.1007/s11357-024-01164-6 false true PublicationIdentifier 26099326 /api/publicationidentifier/26099326 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001207636900001 https://www.webofscience.com/wos/woscc/full-record/001207636900001 false true PublicationIdentifier 26122748 /api/publicationidentifier/26122748 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85191174277 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85191174277 false true PublicationIdentifier 26099324 /api/publicationidentifier/26099324 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38658505 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38658505&dopt=Abstract false true Keyword 643 /api/keyword/643 true 643 true Keyword 6341 /api/keyword/6341 true 6341 true Keyword 19809 /api/keyword/19809 true 19809 true Keyword 1014859 /api/keyword/1014859 true 1014859 true Keyword 3375364 /api/keyword/3375364 true true SjrRating 11505857 /api/sjrrating/11505857 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true /api/publication/34825015 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianchini Giampaolo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület); <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34825015" target="_blank">Prognostic significance of a signature based on senescence-related genes in colorectal cancer</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">46</span> <span class="journal-issue">5</span> <span class="page"> pp 4495-4504 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-024-01164-6" target="_blank" href="https://doi.org/10.1007/s11357-024-01164-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001207636900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001207636900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85191174277" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85191174277"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38658505" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38658505&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span> | Független: 5 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 15 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;15 | DOI jelölt:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34825015&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34825015</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (TKP2021-NKTA-47), (RRF-2.3.1-21-2022-00003), (135784) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2024.11.28. 07:12 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:27 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklah...</pre> </div></div>