https://m2.mtmt.hu/ hun 2026-09-21 09:31 JournalArticle 34813473 VALIDATED true 0 false 2026-09-15T10:14:05.952+0000 2026-03-26T09:44:58.179+0000 2024-04-23T09:28:59.645+0000 true 10011643 Mócsai Attila /api/author/10011643 Author Mócsai Attila (Élettan, sejtbiológia) true 10011643 2026-07-21T05:35:58.804+0000 2024-06-19T10:05:54.350+0000 true 10015181 Nagy Eszter /api/admin/10015181 Admin Nagy Eszter (SZTA admi, admin) true 10015181 Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2025-05-27T08:27:44.422+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Szederkényi, G true true /api/journal/10007440 REVIEWED PLOS ONE 1932-6203 true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 19 4 0299501 0299501 17 2024 Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, Funding 2039535 /api/funding/2039535 Thematic Excellence Program(TKP2021-EGA-42) false true Funding 2039536 /api/funding/2039536 (ÚNKP-22-3) false true Funding 2039537 /api/funding/2039537 OTKA(145934) Támogató: NKFIH false true true true 2024 true true true false true false GOLD 2026-09-15 true https://doi.org/10.1371/journal.pone.0299501 5 0 5 5 1 5 5 4 5 5 5 5 5 5 0 0 5 5 5 5 0 8 8 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 2 2 2 2 Q1 A false 10080211,10000614,10044620,10080212,10023793 false false false 2024-04-23T10:07:42.969+0000 Gyógyszerészeti Intézet (SE / GYTK); Információs Technológiai és Bionikai Kar (PPKE); Rendszer és Irányításelméleti Kutatólaboratórium (HRN SZTAKI); Roska Tamás Műszaki és Természettudományi Dokto... 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(2024) PLOS ONE 1932-6203 19 4<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000614"><a href="/gui2/?type=authors&mode=browse&sel=10000614" target="_blank">Szederkényi G (<span class="authorship-author-name">Szederkényi Gábor</span> <span class="authorAux-mtmt"> Nemlineáris dinamikus rendszerek</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Számítástechnikai és Automatizálási Kutatóintézet">HRN SZTAKI</span>/Rendszer és Irányításelméleti Kutatólaboratórium; <span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080212"><a href="/gui2/?type=authors&mode=browse&sel=10080212" target="_blank">Kocsis D (<span class="authorship-author-name">Kocsis Dorottya</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080211"><a href="/gui2/?type=authors&mode=browse&sel=10080211" target="_blank">Vághy M A (<span class="authorship-author-name">Vághy Mihály András</span> <span class="authorAux-mtmt"> informatika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085536"><a href="/gui2/?type=authors&mode=browse&sel=10085536" target="_blank">Czárán D (<span class="authorship-author-name">Czárán Domonkos Tamás</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085543"><a href="/gui2/?type=authors&mode=browse&sel=10085543" target="_blank">Sasvári P (<span class="authorship-author-name">Sasvári Péter</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020628"><a href="/gui2/?type=authors&mode=browse&sel=10020628" target="_blank">Lengyel M (<span class="authorship-author-name">Lengyel Miléna</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084103"><a href="/gui2/?type=authors&mode=browse&sel=10084103" target="_blank">Naszlady M B (<span class="authorship-author-name">Naszlady Márton Bese</span> <span class="authorAux-mtmt"> Műszaki tudományok</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kreis F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal I (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023793"><a href="/gui2/?type=authors&mode=browse&sel=10023793" target="_blank">Csépányi-Kömi R (<span class="authorship-author-name">Csépányi-Kömi Roland</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044620"><a href="/gui2/?type=authors&mode=browse&sel=10044620" target="_blank">Erdő F ✉ (<span class="authorship-author-name">Erdő Franciska</span> <span class="authorAux-mtmt"> biológia, neurodegenerativ betegségek, gyógysze...</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34813473" target="_blank">Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">4</span> <span class="page"> Paper 0299501. 17 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0299501" target="_blank" href="https://doi.org/10.1371/journal.pone.0299501"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="2740" target="_blank" href="https://publikacio.ppke.hu/id/eprint/2740"> PPKE Publikáció </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001202890500030" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001202890500030"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10730" target="_blank" href="https://eprints.sztaki.hu/10730"> SZTAKI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85190479692" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190479692"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38603673" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38603673&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság II. 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