https://m2.mtmt.hu/ hun 2026-09-21 15:58 JournalArticle 34805614 VALIDATED true Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, United States Export Date: 17 June 2024 CODEN: POREF Correspondence Address: Khoor, A.; Department of Laboratory Medicine and Pathology, United States; email: khoor.andras@mayo.edu 0 false 2026-09-15T16:42:27.104+0000 2024-05-17T06:30:32.549+0000 2024-04-22T13:15:36.003+0000 true 10022176 Laczik Cecilia /api/admin/10022176 Admin Laczik Cecilia (SE_AOK_1Patológia_Admin5_LC, admin) true 10022176 2025-05-14T07:24:53.315+0000 2024-05-17T06:30:32.562+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Krencz, Ildikó true true /api/journal/1035680 REVIEWED PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 30 1611593 1611593 10 2024 RICTOR gene, which encodes the scaffold protein of mTORC2, can be amplified in various tumor types, including squamous cell carcinoma (SCC) of the lung. RICTOR amplification can lead to hyperactivation of mTORC2 and may serve as a targetable genetic alteration, including in lung SCC patients with no PD-L1 expression who are not expected to benefit from immune checkpoint inhibitor therapy. This study aimed to compare RICTOR amplification detected by fluorescence in situ hybridization (FISH) with Rictor and PD-L1 protein expression detected by immunohistochemistry (IHC) in SCC of the lung. The study was complemented by analysis of the publicly available Lung Squamous Cell Carcinoma (TCGA, Firehose legacy) dataset. RICTOR amplification was observed in 20% of our cases and 16% of the lung SCC cases of the TCGA dataset. Rictor and PD-L1 expression was seen in 74% and 44% of the cases, respectively. Rictor IHC showed two staining patterns: membrane staining (16% of the cases) and cytoplasmic staining (58% of the cases). Rictor membrane staining predicted RICTOR amplification as detected by FISH with high specificity (95%) and sensitivity (70%). We did not find any correlation between RICTOR amplification and PD-L1 expression; RICTOR amplification was detected in 18% and 26% of PD-L1 positive and negative cases, respectively. The TCGA dataset analysis showed similar results; RICTOR copy number correlated with Rictor mRNA and protein expression but showed no association with PD-L1 mRNA and protein expression. In conclusion, the correlation between RICTOR amplification and Rictor membrane staining suggests that the latter can potentially be used as a surrogate marker to identify lung SCC cases with RICTOR amplification. Since a significant proportion of PD-L1 negative SCC cases harbor RICTOR amplification, analyzing PD-L1 negative tumors by RICTOR FISH or Rictor IHC can help select patients who may benefit from mTORC2 inhibitor therapy. Funding 2040185 /api/funding/2040185 (FK-128404) Támogató: NKFIH false true Funding 2040186 /api/funding/2040186 (NFTÖ-21-B-0179) false true Funding 2040187 /api/funding/2040187 (ÚNKP-23-4-II-SE-9) false true true true 2024 true true true false true false NONE 2026-09-15 false 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 5 5 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 Q2 false false false false 2024-05-16T06:30:32.266+0000 Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 6 17 1 8 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 116296932 /api/authorship/116296932 Krencz, Ildikó [Krencz, Ildikó (Tüdődaganatok), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 1 0.125 true false false Author 10051986 /api/author/10051986 Krencz Ildikó (Tüdődaganatok) Krencz Ildikó true 10051986 true Krencz Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296933 /api/authorship/116296933 Sztankovics, Dániel [Sztankovics, Dániel (Onkológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 2 0.125 false false false Author 10074525 /api/author/10074525 Sztankovics Dániel (Onkológia) Sztankovics Dániel true true Sztankovics Dániel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296934 /api/authorship/116296934 Sebestyén, Anna [Sebestyén, Anna (Tumorbiológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 3 0.125 false false false Author 10000745 /api/author/10000745 Sebestyén Anna (Tumorbiológia) Sebestyén Anna true 10000745 true Sebestyén Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296935 /api/authorship/116296935 Pápay, Judit [Pápay, Judit (Patológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 4 0.125 false false false Author 10023572 /api/author/10023572 Pápay Judit (Patológia) Pápay Judit true 10023572 true Pápay Judit true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296936 /api/authorship/116296936 Dankó, Titanilla [Dankó, Titanilla (Tumorbiológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 5 0.125 false false false Author 10065723 /api/author/10065723 Dankó Titanilla (Tumorbiológia) Dankó Titanilla true true Dankó Titanilla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296937 /api/authorship/116296937 Moldvai, Dorottya [Moldvai, Dorottya (Tumorbiológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 6 0.125 false false false Author 10078438 /api/author/10078438 Moldvai Dorottya (Tumorbiológia) Moldvai Dorottya true true Moldvai Dorottya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296938 /api/authorship/116296938 Lutz, Elmar 7 0.125 false false false Lutz Elmar true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116296939 /api/authorship/116296939 Khoor, Andras ✉ 8 0.125 false true true Khoor Andras true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true 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(2024) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 30<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051986"><a href="/gui2/?type=authors&mode=browse&sel=10051986" target="_blank">Krencz Ildikó (<span class="authorship-author-name">Krencz Ildikó</span> <span class="authorAux-mtmt"> Tüdődaganatok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074525"><a href="/gui2/?type=authors&mode=browse&sel=10074525" target="_blank">Sztankovics Dániel (<span class="authorship-author-name">Sztankovics Dániel</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000745"><a href="/gui2/?type=authors&mode=browse&sel=10000745" target="_blank">Sebestyén Anna (<span class="authorship-author-name">Sebestyén Anna</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023572"><a href="/gui2/?type=authors&mode=browse&sel=10023572" target="_blank">Pápay Judit (<span class="authorship-author-name">Pápay Judit</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065723"><a href="/gui2/?type=authors&mode=browse&sel=10065723" target="_blank">Dankó Titanilla (<span class="authorship-author-name">Dankó Titanilla</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078438"><a href="/gui2/?type=authors&mode=browse&sel=10078438" target="_blank">Moldvai Dorottya (<span class="authorship-author-name">Moldvai Dorottya</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lutz Elmar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Khoor Andras ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34805614" target="_blank">RICTOR amplification is associated with Rictor membrane staining and does not correlate with PD-L1 expression in lung squamous cell carcinoma</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">30</span> <span class="page"> Paper 1611593. 10 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/pore.2024.1611593" target="_blank" href="https://doi.org/10.3389/pore.2024.1611593"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001216028500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001216028500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85192071757" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192071757"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38706776" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38706776&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34805614&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34805614</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK-128404) Támogató: NKFIH, (NFTÖ-21-B-0179), (ÚNKP-23-4-II-SE-9) </div> <div class="lastModified">Utolsó módosítás: 2024.05.17. 08:30 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, United States Export Date: 17 June 2024 CODEN: POREF Correspondence Address: Khoor, A.; Department of Laboratory Medicine ...</pre> </div></div>