https://m2.mtmt.hu/ hun 2026-09-21 03:48 JournalArticle 34804161 VALIDATED true * Megosztott szerzőség 0 false 2026-09-13T19:32:13.497+0000 2026-01-23T08:00:39.770+0000 2024-04-22T08:53:08.267+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-09-03T12:08:31.573+0000 2024-11-20T09:40:30.380+0000 true 10090847 Horváth Viktória /api/admin/10090847 Admin true 2025-05-14T07:56:03.403+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true 2025-12-18T14:33:13.723+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Csiszar, Anna Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 46 5103 5132 5103 30 2024 Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). This review paper delves into the hypothesis that atherosclerosis, a prevalent age-related large vessel disease, extends its pathological influence into the cerebral microcirculation, thereby contributing to the development and progression of CSVD, with a specific focus on CMHs. We explore the concept of vascular aging as a continuum, bridging macrovascular pathologies like atherosclerosis with microvascular abnormalities characteristic of CSVD. We posit that the same risk factors precipitating accelerated aging in large vessels (i.e., atherogenesis), primarily through oxidative stress and inflammatory pathways, similarly instigate accelerated microvascular aging. Accelerated microvascular aging leads to increased microvascular fragility, which in turn predisposes to the formation of CMHs. The presence of hypertension and amyloid pathology further intensifies this process. We comprehensively overview the current body of evidence supporting this interconnected vascular hypothesis. Our review includes an examination of epidemiological data, which provides insights into the prevalence and impact of CMHs in the context of atherosclerosis and CSVD. Furthermore, we explore the shared mechanisms between large vessel aging, atherogenesis, microvascular aging, and CSVD, particularly focusing on how these intertwined processes contribute to the genesis of CMHs. By highlighting the role of vascular aging in the pathophysiology of CMHs, this review seeks to enhance the understanding of CSVD and its links to systemic vascular disorders. Our aim is to provide insights that could inform future therapeutic approaches and research directions in the realm of neurovascular health. Funding 2039685 /api/funding/2039685 false true Funding 2039686 /api/funding/2039686 false true Funding 2039847 /api/funding/2039847 false true Funding 2039848 /api/funding/2039848 false true true INTERNATIONAL 2024 true true true false true false GOLD 2026-09-13 true https://doi.org/10.1007/s11357-024-01139-7 61 0 61 43 23 61 61 58 60 61 61 43 43 43 18 0 61 43 61 43 0 67 67 Folyóiratcikk Journal Article 24 60 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 46 33 46 33 2026 0 13 8 13 8 D1 false 10011801 false false false 2024-04-21T10:41:41.547+0000 ELKH-PTE Klinikai Idegtudományi Képalkotó Kutat... (PTE / KCS); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI); Idegsebészeti Klinika (PTE / ÁOK); Neurotrauma kutatócsoport (PTE / SZKK); Népegészségtani Intézet (SE / AOK / I); Szemészeti Klinika (SE / AOK / K); Transzlációs Medicina Intézet (SE / AOK / I); Érsebészeti és Endovaszkuláris Tanszék (SE / AOK / K) 8 60 8 16 0 true 10003134 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116287157 /api/authorship/116287157 1 0.063 true false false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287158 /api/authorship/116287158 2 0.063 true false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287159 /api/authorship/116287159 3 0.063 true false false Patai Roland true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287165 /api/authorship/116287165 9 0.0625 false false false Kirkpartrick Angelia C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287166 /api/authorship/116287166 10 0.0625 false false false Prodan Calin I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287167 /api/authorship/116287167 11 0.0625 false false false Liotta Eric M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287168 /api/authorship/116287168 12 0.0625 false false false Zhang Xin A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116287169 /api/authorship/116287169 13 0.063 false false false Author 10021094 /api/author/10021094 Tóth Péter József true 10021094 true Toth Peter true false false AuthorshipType 1 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna<sup>*</sup> ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Patai Roland<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gulej Rafal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy Andriy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyo Zoltan (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025486"><a href="/gui2/?type=authors&mode=browse&sel=10025486" target="_blank">Kovacs Illes (<span class="authorship-author-name">Kovács Illés</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011801"><a href="/gui2/?type=authors&mode=browse&sel=10011801" target="_blank">Sotonyi Peter (<span class="authorship-author-name">Sótonyi Péter</span> <span class="authorAux-mtmt"> Érsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Érsebészeti és Endovaszkuláris Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kirkpartrick Angelia C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Prodan Calin I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liotta Eric M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhang Xin A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021094"><a href="/gui2/?type=authors&mode=browse&sel=10021094" target="_blank">Toth Peter (<span class="authorship-author-name">Tóth Péter József</span> <span class="authorAux-mtmt"> Idegsebészet, cerebrovaszkuláris kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Neurotrauma kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Kutatócsoportok">KCS</span>/ELKH-PTE Klinikai Idegtudományi Képalkotó Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sorond Farzaneh A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34804161" target="_blank">Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">46</span> <span class="page"> pp 5103-5132 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-024-01139-7" target="_blank" href="https://doi.org/10.1007/s11357-024-01139-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001205141700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001205141700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85190756186" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190756186"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38639833" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38639833&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s11357-024-01139-7" target="_blank" href="https://link.springer.com/10.1007/s11357-024-01139-7"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85190756186?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85190756186?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 61</span> | Független: 43 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 58 | Scopus jelölt:&nbsp;60 | WoS/Scopus jelölt:&nbsp;61 | DOI jelölt:&nbsp;61 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34804161&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 67 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34804161</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (135784) Támogató: NKFIH, (101004093/EUniWell/EAC-A02- 2019/EAC-A02-2019-1) </div> <div class="lastModified">Utolsó módosítás: 2026.01.23. 09:00 Balázs András (MTMT Központ, admin) </div> <div class="lockedBy">Központi kezelésű 2025.12.18. 15:33 Wolf György (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>