https://m2.mtmt.hu/ hun 2026-09-21 00:27 JournalArticle 34804106 VALIDATED true 0 false 2026-05-23T18:33:03.204+0000 2024-11-11T11:13:55.715+0000 2024-04-22T08:37:03.875+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin Molnár-Taga Márta (SE_AOK_1Bel_Onkol_Admin5_MTM, admin) true 2026-09-16T23:31:37.991+0000 2026-09-16T23:31:37.991+0000 2024-04-22T08:38:27.797+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Keszler, Gergely true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 8 4477 4477 15 2024 Plasma levels of glial cell line-derived neurotrophic factor (GDNF), a pivotal regulator of differentiation and survival of dopaminergic neurons, are reportedly decreased in schizophrenia. To explore the involvement of GDNF in the pathogenesis of the disease, a case–control association analysis was performed between five non-coding single nucleotide polymorphisms (SNP) across the GDNF gene and schizophrenia. Of them, the ‘G’ allele of the rs11111 SNP located in the 3′ untranslated region (3′-UTR) of the gene was found to associate with schizophrenia. In silico analysis revealed that the rs11111 ‘G’ allele might create binding sites for three microRNA (miRNA) species. To explore the significance of this polymorphism, transient co-transfection assays were performed in human embryonic kidney 293T (HEK293T) cells with a luciferase reporter construct harboring either the ‘A’ or ‘G’ allele of the 3′-UTR of GDNF in combination with the hsa-miR-1185-1-3p pre-miRNA. It was demonstrated that in the presence of the rs11111 ‘G’ (but not the ‘A’) allele, hsa-miR-1185-2-3p repressed luciferase activity in a dose-dependent manner. Deletion of the miRNA binding site or its substitution with the complementary sequence abrogated the modulatory effect. Our results imply that the rs11111 ‘G’ allele occurring more frequently in patients with schizophrenia might downregulate GDNF expression in a miRNA-dependent fashion. Funding 2039445 /api/funding/2039445 (K131680) Támogató: NKFIH false true Funding 2039446 /api/funding/2039446 (TKP2021-EGA-25) false true Funding 2039447 /api/funding/2039447 (2017-1.2.1-NKP-2017-00002.) false true Funding 2039448 /api/funding/2039448 (STIA-18-KF/M) false true true true 2024 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms25084477 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 D1 false 10001130 false false false 2024-04-21T08:38:27.522+0000 Doktori Iskola (SE); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 9 25 3 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 116286955 /api/authorship/116286955 Keszler, Gergely ✉ [Keszler, Gergely (biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.111 true false true Author 10023921 /api/author/10023921 Keszler Gergely (biokémia, molekuláris biológia, molekuláris genetika) Keszler Gergely true 10023921 true Keszler Gergely true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286956 /api/authorship/116286956 Vékony, Bálint* [Vékony, Bálint (endokrinológia, m...), szerző] Doktori Iskola (SE) 2 0.111 true false false Author 10084110 /api/author/10084110 Vékony Bálint (endokrinológia, molekuláris biológia) Vékony Bálint true true Vékony Bálint true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286957 /api/authorship/116286957 Elek, Zsuzsanna [Molnár, Zsuzsanna (Molekuláris genetika), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 0.111 false false false Author 10048126 /api/author/10048126 Molnár Zsuzsanna (Molekuláris genetika) Molnár Zsuzsanna true 10048126 true Elek Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286958 /api/authorship/116286958 Nemoda, Zsófia [Nemoda, Zsófia (Molekuláris genetika), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 0.111 false false false Author 10013858 /api/author/10013858 Nemoda Zsófia (Molekuláris genetika) Nemoda Zsófia true 10013858 true Nemoda Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286959 /api/authorship/116286959 Angyal, Nóra [Angyal, Nóra (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 5 0.111 false false false Author 10059389 /api/author/10059389 Angyal Nóra (Biokémia) Angyal Nóra true 10059389 true Angyal Nóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286960 /api/authorship/116286960 Bánlaki, Zsófia [Bánlaki, Zsófia (molekuláris biológia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 6 0.111 false false false Author 10029333 /api/author/10029333 Bánlaki Zsófia (molekuláris biológia) Bánlaki Zsófia true 10029333 true Bánlaki Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286961 /api/authorship/116286961 Kovács-Nagy, Réka [Kovács-Nagy, Réka (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 7 0.111 false false false Author 10032148 /api/author/10032148 Kovács-Nagy Réka (Biokémia) Kovács-Nagy Réka true 10032148 true Kovács-Nagy Réka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286962 /api/authorship/116286962 Rónai, Zsolt [Rónai, Zsolt (Molekuláris genetika), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 8 0.111 false false false Author 10001130 /api/author/10001130 Rónai Zsolt (Molekuláris genetika) Rónai Zsolt true 10001130 true Rónai Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116286963 /api/authorship/116286963 Réthelyi, János M. 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McGrath 2008: Schizophrenia: A concise overview of incidence, prevalence, and mortality., Epidemiol. Rev., 30, p. 67, DOI: 10.1093/epirev/mxn001 1 10.1093/epirev/mxn001 false true Reference 52131567 /api/reference/52131567 2. Davies 2020: Prenatal and perinatal risk and protective factors for psychosis: A systematic review and meta-analysis., Lancet Psychiatry, 7, p. 399, DOI: 10.1016/S2215-0366(20)30057-2 2 10.1016/S2215-0366(20)30057-2 false true Reference 52131568 /api/reference/52131568 3. Trubetskoy 2022: Mapping genomic loci implicates genes and synaptic biology in schizophrenia., Nature, 604, p. 502, DOI: 10.1038/s41586-022-04434-5 3 10.1038/s41586-022-04434-5 false true Reference 52131569 /api/reference/52131569 4. Chu 2018: Serum nerve growth factor beta, brain- and glial-derived neurotrophic factor levels and psychopathology in unmedicated patients with schizophrenia., J. Chin. Med. Assoc., 81, p. 577, DOI: 10.1016/j.jcma.2017.11.010 4 10.1016/j.jcma.2017.11.010 false true Reference 52131570 /api/reference/52131570 5. Tang, X., Zhou, C., Gao, J., Duan, W., Yu, M., Xiao, W., Zhang, X., Dong, H., Wang, X., and Zhang, X. (2019). Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction. BMC Psychiatry, 19., DOI: 10.1186/s12888-019-2231-3 5 10.1186/s12888-019-2231-3 false true Reference 52131571 /api/reference/52131571 6. Dremencov 2021: Trophic factors as potential therapies for treatment of major mental disorders., Neurosci. Lett., 764, p. 136194, DOI: 10.1016/j.neulet.2021.136194 6 10.1016/j.neulet.2021.136194 false true Reference 52131572 /api/reference/52131572 7. Kim, M., and Kim, D.J. (2018). GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance. Int. J. Mol. Sci., 19., DOI: 10.3390/ijms19041078 7 10.3390/ijms19041078 false true Reference 52131573 /api/reference/52131573 8. Sharma 2018: Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis., Development, 145, p. dev151555, DOI: 10.1242/dev.151555 8 10.1242/dev.151555 false true Reference 52131574 /api/reference/52131574 9. Costantini 2006: GDNF/Ret signaling and the development of the kidney., Bioessays, 28, p. 117, DOI: 10.1002/bies.20357 9 10.1002/bies.20357 false true Reference 52131575 /api/reference/52131575 10. Tao 2019: Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling., Gut, 68, p. 2214, DOI: 10.1136/gutjnl-2018-317872 10 10.1136/gutjnl-2018-317872 false true Reference 52131576 /api/reference/52131576 11. Brisch 2014: The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: Old fashioned, but still in vogue., Front. Psychiatry, 5, p. 47 11 false true Reference 52131577 /api/reference/52131577 12. Matlik 2018: Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects., Sci. Rep., 8, p. 11861, DOI: 10.1038/s41598-018-29988-1 12 10.1038/s41598-018-29988-1 false true Reference 52131578 /api/reference/52131578 13. Tunca 2015: Diverse glial cell line-derived neurotrophic factor (GDNF) support between mania and schizophrenia: A comparative study in four major psychiatric disorders., Eur. Psychiatry, 30, p. 198, DOI: 10.1016/j.eurpsy.2014.11.003 13 10.1016/j.eurpsy.2014.11.003 false true Reference 52131579 /api/reference/52131579 14. Turkmen, B.A., Yazici, E., Erdogan, D.G., Suda, M.A., and Yazici, A.B. (2021). BDNF, GDNF, NGF and Klotho levels and neurocognitive functions in acute term of schizophrenia. BMC Psychiatry, 21., DOI: 10.1186/s12888-021-03578-4 14 10.1186/s12888-021-03578-4 false true Reference 52131580 /api/reference/52131580 15. Xiao 2016: Atypical antipsychotic treatment increases glial cell line-derived neurotrophic factor serum levels in drug-free schizophrenic patients along with improvement of psychotic symptoms and therapeutic effects., Psychiatry Res., 246, p. 617, DOI: 10.1016/j.psychres.2016.11.001 15 10.1016/j.psychres.2016.11.001 false true Reference 52131581 /api/reference/52131581 16. Yuan 2022: Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets., Comput. Math. Methods Med., 2022, p. 6580030, DOI: 10.1155/2022/6580030 16 10.1155/2022/6580030 false true Reference 52131582 /api/reference/52131582 17. Skibinska 2017: Glial Cell Line-Derived Neurotrophic Factor (GDNF) serum level in women with schizophrenia and depression, correlation with clinical and metabolic parameters., Psychiatry Res., 256, p. 396, DOI: 10.1016/j.psychres.2017.07.014 17 10.1016/j.psychres.2017.07.014 false true Reference 52131583 /api/reference/52131583 18. Niitsu 2014: Association between serum levels of glial cell-line derived neurotrophic factor and attention deficits in schizophrenia., Neurosci. Lett., 575, p. 37, DOI: 10.1016/j.neulet.2014.05.034 18 10.1016/j.neulet.2014.05.034 false true Reference 52131584 /api/reference/52131584 19. Hidese 2020: Cerebrospinal fluid neuroplasticity-associated protein levels in patients with psychiatric disorders: A multiplex immunoassay study., Transl. Psychiatry, 10, p. 161, DOI: 10.1038/s41398-020-0843-5 19 10.1038/s41398-020-0843-5 false true Reference 52131585 /api/reference/52131585 20. Matlik 2022: Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia., Mol. Psychiatry, 27, p. 3247, DOI: 10.1038/s41380-022-01554-2 20 10.1038/s41380-022-01554-2 false true Reference 52131586 /api/reference/52131586 21. Shiwaku 2022: Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice., Cell Rep. Med., 3, p. 100597, DOI: 10.1016/j.xcrm.2022.100597 21 10.1016/j.xcrm.2022.100597 false true Reference 52131587 /api/reference/52131587 22. Lee 2001: Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: Polymorphism screening and association analysis., Psychiatry Res., 104, p. 11, DOI: 10.1016/S0165-1781(01)00294-3 22 10.1016/S0165-1781(01)00294-3 false true Reference 52131588 /api/reference/52131588 23. Michelato 2004: 3′ UTR (AGG)n repeat of glial cell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia., Neurosci. Lett., 357, p. 235, DOI: 10.1016/j.neulet.2003.12.089 23 10.1016/j.neulet.2003.12.089 false true Reference 52131589 /api/reference/52131589 24. Williams 2007: Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia., Schizophr. Res., 97, p. 271, DOI: 10.1016/j.schres.2007.09.004 24 10.1016/j.schres.2007.09.004 false true Reference 52131590 /api/reference/52131590 25. Ma 2013: Association of the GDNF gene with depression and heroin dependence, but not schizophrenia, in a Chinese population., Psychiatry Res., 210, p. 1296, DOI: 10.1016/j.psychres.2013.08.025 25 10.1016/j.psychres.2013.08.025 false true Reference 52131591 /api/reference/52131591 26. Souza 2010: Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response., J. Psychiatr. Res., 44, p. 700, DOI: 10.1016/j.jpsychires.2010.01.002 26 10.1016/j.jpsychires.2010.01.002 false true Reference 52131592 /api/reference/52131592 27. Safari 2017: Glial cell-derived neurotrophic factor gene polymorpisms affect severity and functionality of bipolar disorder., J. Integr. Neurosci., 16, p. 471, DOI: 10.3233/JIN-170031 27 10.3233/JIN-170031 false true Reference 52131593 /api/reference/52131593 28. Kotyuk, E., Keszler, G., Nemeth, N., Ronai, Z., Sasvari-Szekely, M., and Szekely, A. (2013). Glial cell line-derived neurotrophic factor (GDNF) as a novel candidate gene of anxiety. PLoS ONE, 8., DOI: 10.1371/journal.pone.0080613 28 10.1371/journal.pone.0080613 false true Reference 52131594 /api/reference/52131594 29. Kotyuk 2013: Association between mood characteristics and polymorphisms of glial cell line-derived neurotrophic factor (GNDF) in patients with depression., Neuropsychopharmacol. Hung., 15, p. 63 29 false true Reference 52131595 /api/reference/52131595 30. Kotyuk 2016: Association between smoking behaviour and genetic variants of glial cell line-derived neurotrophic factor., J. Genet., 95, p. 811, DOI: 10.1007/s12041-016-0701-7 30 10.1007/s12041-016-0701-7 false true Reference 52131596 /api/reference/52131596 31. Vereczkei, A., Barta, C., Magi, A., Farkas, J., Eisinger, A., Kiraly, O., Belik, A., Griffiths, M.D., Szekely, A., and Sasvari-Szekely, M. (2022). FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. J. Pers. Med., 12., DOI: 10.3390/jpm12050690 31 10.3390/jpm12050690 false true Reference 52131597 /api/reference/52131597 32. Das 2019: Association of GDNF and CNTNAP2 gene variants with gambling., J. Behav. Addict., 8, p. 471, DOI: 10.1556/2006.8.2019.40 32 10.1556/2006.8.2019.40 false true Reference 52131598 /api/reference/52131598 33. Carrillo 2015: GDNF gene is associated with tourette syndrome in a family study., Mov. Disord., 30, p. 1115, DOI: 10.1002/mds.26279 33 10.1002/mds.26279 false true Reference 52131599 /api/reference/52131599 34. Rethelyi 2010: Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample., Am. J. Med. Genet. Part B Neuropsychiatr. Genet., 153B, p. 792, DOI: 10.1002/ajmg.b.31049 34 10.1002/ajmg.b.31049 false true Reference 52131600 /api/reference/52131600 35. Keller 2022: miRNATissueAtlas2: An update to the human miRNA tissue atlas., Nucleic Acids Res., 50, p. D211, DOI: 10.1093/nar/gkab808 35 10.1093/nar/gkab808 false true Reference 52131601 /api/reference/52131601 36. Wang, C., Zhao, X., Wu, Z., Huang, G., Lin, R., Chen, H., Xu, K., Sun, K., Zhou, H., and Shu, J. (2024). Identification of Differentially Expressed mRNAs and miRNAs and Related Regulatory Networks in Cumulus Oophorus Complexes Associated with Fertilization. Reprod. Sci., online, ahead of print., DOI: 10.1007/s43032-023-01413-7 36 10.1007/s43032-023-01413-7 false true Reference 52131602 /api/reference/52131602 37. Mukherjee 2022: Investigating the interference of single nucleotide polymorphisms with miRNA mediated gene regulation in pancreatic ductal adenocarcinoma: An in silico approach., Gene, 819, p. 146259, DOI: 10.1016/j.gene.2022.146259 37 10.1016/j.gene.2022.146259 false true Reference 52131603 /api/reference/52131603 38. Mirabbasi, R., Ebrahimi, S.O., Tavakoli, F., and Reiisi, S. (2023). Novel polymorphism rs12402181 in the mature sequence of hsa-miR-3117-3p has a protective effect against breast cancer development by affecting miRNA processing and function. 3 Biotech, 13., DOI: 10.1007/s13205-023-03765-y 38 10.1007/s13205-023-03765-y false true Reference 52131604 /api/reference/52131604 39. Zhu 2022: Circular RNA-VPS13A attenuates diabetes-induced enteric glia damage by targeting miR-182/GDNF Axis., Acta Biochim. Biophys. Sin., 54, p. 999, DOI: 10.3724/abbs.2022073 39 10.3724/abbs.2022073 false true Reference 52131605 /api/reference/52131605 40. Ravegnini 2019: The rs17084733 variant in the KIT 3′ UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: A sponge-like mechanism conferring disease susceptibility., Epigenetics, 14, p. 545, DOI: 10.1080/15592294.2019.1595997 40 10.1080/15592294.2019.1595997 false true Reference 52131606 /api/reference/52131606 41. Konovalova, J., Gerasymchuk, D., Arroyo, S.N., Kluske, S., Mastroianni, F., Pereyra, A.V., and Domanskyi, A. (2021). Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs. Int. J. Mol. Sci., 22., DOI: 10.3390/ijms22189691 41 10.3390/ijms22189691 false true Reference 52131607 /api/reference/52131607 42. Akkouh 2021: Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia., Brain Behav. Immun., 94, p. 235, DOI: 10.1016/j.bbi.2021.01.037 42 10.1016/j.bbi.2021.01.037 false true Reference 52131608 /api/reference/52131608 43. Gash 2020: GDNF clinical trials for Parkinson’s disease: A critical human dimension., Cell Tissue Res., 382, p. 65, DOI: 10.1007/s00441-020-03269-8 43 10.1007/s00441-020-03269-8 false true Reference 52131609 /api/reference/52131609 44. Shim 2015: Increased levels of plasma glial-derived neurotrophic factor in children with attention deficit hyperactivity disorder., Nord. J. Psychiatry, 69, p. 546, DOI: 10.3109/08039488.2015.1014834 44 10.3109/08039488.2015.1014834 false true Reference 52131610 /api/reference/52131610 45. Oh-hashi, K., Hirata, Y., and Kiuchi, K. (2012). Characterization of 3′-untranslated region of the mouse GDNF gene. BMC Mol. Biol., 13., DOI: 10.1186/1471-2199-13-2 45 10.1186/1471-2199-13-2 false true Reference 52131611 /api/reference/52131611 46. Kumar, A., Kopra, J., Varendi, K., Porokuokka, L.L., Panhelainen, A., Kuure, S., Marshall, P., Karalija, N., Harma, M.A., and Vilenius, C. (2015). GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function. PLoS Genet., 11., DOI: 10.1371/journal.pgen.1005710 46 10.1371/journal.pgen.1005710 false true Reference 52131612 /api/reference/52131612 47. Matlik 2023: In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3’UTR editing., Heliyon, 9, p. e13844, DOI: 10.1016/j.heliyon.2023.e13844 47 10.1016/j.heliyon.2023.e13844 false true Reference 52131613 /api/reference/52131613 48. Yue 2019: Inhibition of miR-17-5p promotes mesenchymal stem cells to repair spinal cord injury., Eur. Rev. Med. Pharmacol. Sci., 23, p. 3899 48 false true Reference 52131614 /api/reference/52131614 49. Zhang 2019: Downregulation of MicroRNA-33-5p Protected Bupivacaine-Induced Apoptosis in Murine Dorsal Root Ganglion Neurons Through GDNF., Neurotox. Res., 35, p. 860, DOI: 10.1007/s12640-018-9994-z 49 10.1007/s12640-018-9994-z false true Reference 52131615 /api/reference/52131615 50. Zheng, T., Zhang, T., Zhang, W., Lv, K., Jia, D., Yang, F., Sun, Y., Lian, J., and Wang, R. (2020). Icariside II facilitates the differentiation of ADSCs to schwann cells and restores erectile dysfunction through regulation of miR-33/GDNF axis. Biomed. Pharmacother., 125., DOI: 10.1016/j.biopha.2020.109888 50 10.1016/j.biopha.2020.109888 false true Reference 52131616 /api/reference/52131616 51. Shen 2020: MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF., Gene Ther., 27, p. 254, DOI: 10.1038/s41434-019-0114-3 51 10.1038/s41434-019-0114-3 false true Reference 52131617 /api/reference/52131617 52. Weng 2020: MicroRNA-451 Aggravates Kainic Acid-induced Seizure and Neuronal Apoptosis by Targeting GDNF., Curr. Neurovasc. Res., 17, p. 50, DOI: 10.2174/1567202617666191223150510 52 10.2174/1567202617666191223150510 false true Reference 52131618 /api/reference/52131618 53. Yoong 2006: Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRα2., J. Neurochem., 98, p. 1149, DOI: 10.1111/j.1471-4159.2006.03959.x 53 10.1111/j.1471-4159.2006.03959.x false true Reference 52131619 /api/reference/52131619 54. Jin 2022: Identification of Peripheral Blood miRNA Biomarkers in First-Episode Drug-Free Schizophrenia Patients Using Bioinformatics Strategy., Mol. Neurobiol., 59, p. 4730, DOI: 10.1007/s12035-022-02878-4 54 10.1007/s12035-022-02878-4 false true Reference 52131620 /api/reference/52131620 55. Usuba 2019: Circulating miRNA panels for specific and early detection in bladder cancer., Cancer Sci., 110, p. 408, DOI: 10.1111/cas.13856 55 10.1111/cas.13856 false true Reference 52131621 /api/reference/52131621 56. Alqurashi 2019: miR-496, miR-1185, miR-654, miR-3183 and miR-495 are downregulated in colorectal cancer cells and have putative roles in the mTOR pathway., Oncol. Lett., 18, p. 1657 56 false true Reference 52131622 /api/reference/52131622 57. Wang 2020: SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness., Cancer Res., 80, p. 5257, DOI: 10.1158/0008-5472.CAN-19-3188 57 10.1158/0008-5472.CAN-19-3188 false true Reference 52131623 /api/reference/52131623 58. Garcia-Lacarte, M., Mansego, M.L., Zulet, M.A., Martinez, J.A., and Milagro, F.I. (2019). miR-1185-1 and miR-548q Are Biomarkers of Response to Weight Loss and Regulate the Expression of GSK3B. Cells, 8., DOI: 10.3390/cells8121548 58 10.3390/cells8121548 false true Reference 52131624 /api/reference/52131624 59. Delay 2016: miRNA-dependent target regulation: Functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease., Alzheimers Res. Ther., 8, p. 20, DOI: 10.1186/s13195-016-0186-x 59 10.1186/s13195-016-0186-x false true Reference 52131625 /api/reference/52131625 60. Elek 2013: Association of aggression with a novel microRNA binding site polymorphism in the wolframin gene., Am. J. Med. Genet. Part B Neuropsychiatr. Genet., 162B, p. 404 60 false true Reference 52131626 /api/reference/52131626 61. Bitter 1998: The Hungarian version of the M.I.N.I. and the M.I.N.I. Plus., Psychiatr. Hung., 13, p. 160 61 false true Reference 52131627 /api/reference/52131627 62. Liu, H., and Naismith, J.H. (2008). An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol. BMC Biotechnol., 8., DOI: 10.1186/1472-6750-8-91 62 10.1186/1472-6750-8-91 false true Reference 52131628 /api/reference/52131628 63. Barrett 2005: Haploview: Analysis and visualization of LD and haplotype maps., Bioinformatics, 21, p. 263, DOI: 10.1093/bioinformatics/bth457 63 10.1093/bioinformatics/bth457 false true Reference 52131629 /api/reference/52131629 64. Menyhart, O., Weltz, B., and Gyorffy, B. (2021). MultipleTesting.com: A tool for life science researchers for multiple hypothesis testing correction. PLoS ONE, 16., DOI: 10.1371/journal.pone.0245824 64 10.1371/journal.pone.0245824 false true /api/publication/34804106 Keszler Gergely et al. MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism. (2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 8<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023921"><a href="/gui2/?type=authors&mode=browse&sel=10023921" target="_blank">Keszler Gergely ✉ (<span class="authorship-author-name">Keszler Gergely</span> <span class="authorAux-mtmt"> biokémia, molekuláris biológia, molekuláris gen...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084110"><a href="/gui2/?type=authors&mode=browse&sel=10084110" target="_blank">Vékony Bálint^* (<span class="authorship-author-name">Vékony Bálint</span> <span class="authorAux-mtmt"> endokrinológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048126"><a href="/gui2/?type=authors&mode=browse&sel=10048126" target="_blank">Elek Zsuzsanna (<span class="authorship-author-name">Molnár Zsuzsanna</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013858"><a href="/gui2/?type=authors&mode=browse&sel=10013858" target="_blank">Nemoda Zsófia (<span class="authorship-author-name">Nemoda Zsófia</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059389"><a href="/gui2/?type=authors&mode=browse&sel=10059389" target="_blank">Angyal Nóra (<span class="authorship-author-name">Angyal Nóra</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029333"><a href="/gui2/?type=authors&mode=browse&sel=10029333" target="_blank">Bánlaki Zsófia (<span class="authorship-author-name">Bánlaki Zsófia</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032148"><a href="/gui2/?type=authors&mode=browse&sel=10032148" target="_blank">Kovács-Nagy Réka (<span class="authorship-author-name">Kovács-Nagy Réka</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001130"><a href="/gui2/?type=authors&mode=browse&sel=10001130" target="_blank">Rónai Zsolt (<span class="authorship-author-name">Rónai Zsolt</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021998"><a href="/gui2/?type=authors&mode=browse&sel=10021998" target="_blank">Réthelyi János M. (<span class="authorship-author-name">Réthelyi János</span> <span class="authorAux-mtmt"> Pszichiátria- kognítiv idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34804106" target="_blank">MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">8</span> <span class="page"> Paper 4477. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25084477" target="_blank" href="https://doi.org/10.3390/ijms25084477"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001210146400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001210146400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85208123939" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85208123939"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38674063" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38674063&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34804106&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34804106</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K131680) Támogató: NKFIH, (TKP2021-EGA-25), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (STIA-18-KF/M) </div> <div class="lastModified">Utolsó módosítás: 2024.11.11. 12:13 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>