https://m2.mtmt.hu/ hun 2026-09-21 02:13 JournalArticle 34799254 VALIDATED true 0 false 2026-09-08T08:53:08.245+0000 2024-07-02T11:53:56.374+0000 2024-04-19T07:17:34.055+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2024-10-08T07:19:12.912+0000 2024-10-08T07:19:12.912+0000 2024-07-02T11:53:56.624+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Gibson, C. Michael Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 390 17 1560 1571 1560 11 2024 Background Cardiovascular events frequently recur after acute myocardial infarction, and low cholesterol efflux - a process mediated by apolipoprotein A1, which is the main protein in high-density lipoprotein - has been associated with an increased risk of cardiovascular events. CSL112 is human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity. Whether infusions of CSL112 can reduce the risk of recurrent cardiovascular events after acute myocardial infarction is unclear.Methods We conducted an international, double-blind, placebo-controlled trial involving patients with acute myocardial infarction, multivessel coronary artery disease, and additional cardiovascular risk factors. Patients were randomly assigned to receive either four weekly infusions of 6 g of CSL112 or matching placebo, with the first infusion administered within 5 days after the first medical contact for the acute myocardial infarction. The primary end point was a composite of myocardial infarction, stroke, or death from cardiovascular causes from randomization through 90 days of follow-up.Results A total of 18,219 patients were included in the trial (9112 in the CSL112 group and 9107 in the placebo group). There was no significant difference between the groups in the risk of a primary end-point event at 90 days of follow-up (439 patients [4.8%] in the CSL112 group vs. 472 patients [5.2%] in the placebo group; hazard ratio, 0.93; 95% confidence interval [CI], 0.81 to 1.05; P=0.24), at 180 days of follow-up (622 patients [6.9%] vs. 683 patients [7.6%]; hazard ratio, 0.91; 95% CI, 0.81 to 1.01), or at 365 days of follow-up (885 patients [9.8%] vs. 944 patients [10.5%]; hazard ratio, 0.93; 95% CI, 0.85 to 1.02). The percentage of patients with adverse events was similar in the two groups; a higher number of hypersensitivity events was reported in the CSL112 group.Conclusions Among patients with acute myocardial infarction, multivessel coronary artery disease, and additional cardiovascular risk factors, four weekly infusions of CSL112 did not result in a lower risk of myocardial infarction, stroke, or death from cardiovascular causes than placebo through 90 days. (Funded by CSL Behring; AEGIS-II ClinicalTrials.gov number, NCT03473223.) In patients with acute MI, multivessel coronary artery disease, and other cardiovascular risk factors, CSL112 did not reduce the risk of MI, stroke, or death from cardiovascular causes. true INTERNATIONAL 2024 true true true false true false NONE 2026-09-08 false 120 0 120 108 2 120 118 107 116 120 120 108 108 108 12 0 120 108 120 108 0 1 1 Folyóiratcikk Journal Article 24 119 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 31 27 31 27 2025 0 52 46 52 46 2026 0 37 35 37 35 D1 false false false false 2024-07-01T11:53:48.596+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Repülõ- és Űrorvostani Tanszék (SE / AOK / K); Sportorvostan Tanszék (SE / AOK / K) 1 26 3 35 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116247490 /api/authorship/116247490 1 0.0 true false true Gibson C. 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Michael ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Repülõ- és Űrorvostani Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (35) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">AEGIS II Comm & Investigators</span> </div> <div><a target="_blank" href="/api/publication/34799254?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34799254" target="_blank">Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">390</span> <span class="journal-issue">17</span> <span class="page"> pp 1560-1571 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2400969" target="_blank" href="https://doi.org/10.1056/NEJMoa2400969"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001197648900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001197648900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85192037946" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192037946"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38587254" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38587254&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 120</span> | Független: 108 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 107 | Scopus jelölt:&nbsp;116 | WoS/Scopus jelölt:&nbsp;120 | DOI jelölt:&nbsp;118 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34799254&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34799254</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2024.07.02. 13:53 Berhidi Anna (SE_KK_Admin5_BA, admin) </div> </div></div>