Introduction: Colorectal carcinomas (CRC) are one of the most frequent malignancies
worldwide. Based on gene expression profile analysis, CRCs can be classified into
four distinct subtypes also known as the consensus molecular subtypes (CMS), which
predict biological behaviour. Besides CMS, several other aspects of tumor microenvironment
(TME) and systemic inflammatory response (SIR) influence the outcome of CRC patients.
TME and inflammation have important role in the immune (CMS1) and mesenchymal (CMS4)
subtypes, however, the relationship between these and systemic inflammation has not
been assessed yet. Our objective was to evaluate the connection between CMS, TME and
SIR, and to analyze the correlation between these markers and routinely used tumor
markers, such as CEA (Carcinoembryonic Antigen) and CA19-9 (Carbohydrate Antigen 19-9).
