https://m2.mtmt.hu/ hun 2026-09-21 06:42 JournalArticle 34794459 VALIDATED true Cited By :10 Export Date: 11 December 2024 Correspondence Address: Kapuy, O.; Department of Molecular Biology, Hungary; email: kapuy.orsolya@semmelweis.hu Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, FK 134267 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: The work was financially supported by the National Research, Development and Innovation Fund of Hungary under Grant FK 134267. 0 false 2026-09-14T13:28:57.053+0000 2024-05-15T12:10:05.901+0000 2024-04-17T07:02:03.296+0000 true 10026330 Kapuy Orsolya /api/author/10026330 Author Kapuy Orsolya (Biokémia) true 10026330 2026-04-20T07:20:44.081+0000 2024-05-07T07:30:40.881+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Kapuy, Orsolya true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 8 4368 4368 16 2024 Dynamic regulation of the cellular proteome is mainly controlled in the endoplasmic reticulum (ER). Accumulation of misfolded proteins due to ER stress leads to the activation of unfolded protein response (UPR). The primary role of UPR is to reduce the bulk of damages and try to drive back the system to the former or a new homeostatic state by autophagy, while an excessive level of stress results in apoptosis. It has already been proven that the proper order and characteristic features of both surviving and self-killing mechanisms are controlled by negative and positive feedback loops, respectively. The new results suggest that these feedback loops are found not only within but also between branches of the UPR, fine-tuning the response to ER stress. In this review, we summarize the recent knowledge of the dynamical characteristic of endoplasmic reticulum stress response mechanism by using both theoretical and molecular biological techniques. In addition, this review pays special attention to describing the mechanism of action of the dynamical features of the feedback loops controlling cellular life-and-death decision upon ER stress. Since ER stress appears in diseases that are common worldwide, a more detailed understanding of the behaviour of the stress response is of medical importance. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 8<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10026330"><a href="/gui2/?type=authors&mode=browse&sel=10026330" target="_blank">Kapuy Orsolya ✉ (<span class="authorship-author-name">Kapuy Orsolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34794459" target="_blank">Mechanism of Decision Making between Autophagy and Apoptosis Induction upon Endoplasmic Reticulum Stress</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">8</span> <span class="page"> Paper 4368. 16 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms25084368" target="_blank" href="https://doi.org/10.3390/ijms25084368"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001210477700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001210477700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85191367334" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85191367334"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38673953" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38673953&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 61</span> | Független: 60 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 53 | Scopus jelölt:&nbsp;59 | WoS/Scopus jelölt:&nbsp;61 | DOI jelölt:&nbsp;61 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34794459&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34794459</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK-134267) </div> <div class="lastModified">Utolsó módosítás: 2024.05.15. 14:10 Sonnevend Kinga (SE_AOK_OrvVegytan_Admin5_SK, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :10 Export Date: 11 December 2024 Correspondence Address: Kapuy, O.; Department of Molecular Biology, Hungary; email: kapuy.orsolya@semmelweis.hu Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, FK 134267 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós A...</pre> </div></div>