https://m2.mtmt.hu/ hun 2026-10-24 08:51 JournalArticle 34788748 VALIDATED true 0 false 2026-10-16T09:07:28.178+0000 2025-07-18T07:24:47.218+0000 2024-04-15T06:44:19.048+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-07-18T07:24:22.692+0000 2025-07-18T07:24:22.692+0000 2025-07-18T07:24:47.224+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Fazekas, Tamas Magnetic Resonance Imaging in Prostate Cancer Screening : A Systematic Review and Meta-Analysis true true /api/journal/10057772 REVIEWED true false 10057772 false 10057772 true 2374-2437 2374-2445 Journal FOREIGN 10 6 745 754 745 10 2024 Importance Prostate magnetic resonance imaging (MRI) is increasingly integrated within the prostate cancer (PCa) early detection pathway. Objective To systematically evaluate the existing evidence regarding screening pathways incorporating MRI with targeted biopsy and assess their diagnostic value compared with prostate-specific antigen (PSA)-based screening with systematic biopsy strategies. Data Sources PubMed/MEDLINE, Embase, Cochrane/Central, Scopus, and Web of Science (through May 2023). Study Selection Randomized clinical trials and prospective cohort studies were eligible if they reported data on the diagnostic utility of prostate MRI in the setting of PCa screening. Data Extraction Number of screened individuals, biopsy indications, biopsies performed, clinically significant PCa (csPCa) defined as International Society of Urological Pathology (ISUP) grade 2 or higher, and insignificant (ISUP1) PCas detected were extracted. Main Outcomes and Measures The primary outcome was csPCa detection rate. Secondary outcomes included clinical insignificant PCa detection rate, biopsy indication rates, and the positive predictive value for the detection of csPCa. Data Synthesis The generalized mixed-effect approach with pooled odds ratios (ORs) and random-effect models was used to compare the MRI-based and PSA-only screening strategies. Separate analyses were performed based on the timing of MRI (primary/sequential after a PSA test) and cutoff (Prostate Imaging Reporting and Data System [PI-RADS] score >= 3 or >= 4) for biopsy indication. Results Data were synthesized from 80 114 men from 12 studies. Compared with standard PSA-based screening, the MRI pathway (sequential screening, PI-RADS score >= 3 cutoff for biopsy) was associated with higher odds of csPCa when tests results were positive (OR, 4.15; 95% CI, 2.93-5.88; P <= .001), decreased odds of biopsies (OR, 0.28; 95% CI, 0.22-0.36; P <= .001), and insignificant cancers detected (OR, 0.34; 95% CI, 0.23-0.49; P = .002) without significant differences in the detection of csPCa (OR, 1.02; 95% CI, 0.75-1.37; P = .86). Implementing a PI-RADS score of 4 or greater threshold for biopsy selection was associated with a further reduction in the odds of detecting insignificant PCa (OR, 0.23; 95% CI, 0.05-0.97; P = .048) and biopsies performed (OR, 0.19; 95% CI, 0.09-0.38; P = .01) without differences in csPCa detection (OR, 0.85; 95% CI, 0.49-1.45; P = .22). Conclusion and relevance The results of this systematic review and meta-analysis suggest that integrating MRI in PCa screening pathways is associated with a reduced number of unnecessary biopsies and overdiagnosis of insignificant PCa while maintaining csPCa detection as compared with PSA-only screening. Funding 2039184 /api/funding/2039184 false true Funding 2039185 /api/funding/2039185 false true true 2024 true true true false true false NONE 2026-10-16 false 93 0 93 84 1 93 92 83 87 93 93 84 84 84 9 0 93 84 93 84 0 0 0 Folyóiratcikk Journal Article 24 93 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 15 14 15 14 2025 0 32 28 32 28 2026 0 46 42 46 42 D1 false 10042217,10013343 false false false 2024-06-25T07:15:48.226+0000 Sztochasztika Tanszék (BME / TTK / MI); Transzlációs Medicina Központ (SE / KSZE); Urológiai Klinika (SE / AOK / K) 4 24 3 18 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116186803 /api/authorship/116186803 1 0.056 true false false Author 10073300 /api/author/10073300 Fazekas Tamás true true Fazekas Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116186804 /api/authorship/116186804 2 0.055555556 false false false Shim Sung Ryul true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116186805 /api/authorship/116186805 3 0.055555556 false false false Basile Giuseppe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116186806 /api/authorship/116186806 4 0.055555556 false false false Baboudjian Michael true false false AuthorshipType 1 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<div class="autype autype0"> <span class="author-name" mtid="10073300"><a href="/gui2/?type=authors&mode=browse&sel=10073300" target="_blank">Fazekas Tamas (<span class="authorship-author-name">Fazekas Tamás</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shim Sung Ryul </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Basile Giuseppe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Baboudjian Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042217"><a href="/gui2/?type=authors&mode=browse&sel=10042217" target="_blank">Koi Tamas (<span class="authorship-author-name">Kói Tamás</span> <span class="authorAux-mtmt"> információelmélet</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Matematika Intézet">MI</span>/Sztochasztika Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Przydacz Mikolaj </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Abufaraj Mohammad </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ploussard Guillaume </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kasivisvanathan Veeru </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rivas Juan Gomez </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gandaglia Giorgio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schoots Ivo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van den Bergh Roderick </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leapman Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirady Peter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shariat Shahrokh ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rajwa Pawel </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34788748" target="_blank">Magnetic Resonance Imaging in Prostate Cancer Screening : A Systematic Review and Meta-Analysis</a></div> <div> <span class="journal-title">JAMA ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2374-2437">2374-2437</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2374-2445">2374-2445</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">6</span> <span class="page"> pp 745-754 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1001/jamaoncol.2024.0734" target="_blank" href="https://doi.org/10.1001/jamaoncol.2024.0734"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001197555300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001197555300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85190242344" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190242344"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="38576242" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38576242&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 93</span> | Független: 84 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 83 | Scopus jelölt:&nbsp;87 | WoS/Scopus jelölt:&nbsp;93 | DOI jelölt:&nbsp;92 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34788748</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (ÚNKP-22-3-1-SE-19), (Hungarian National Eotvos Grant) </div> <div class="lastModified">Utolsó módosítás: 2025.07.18. 09:24 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> </div></div>