https://m2.mtmt.hu/ hun 2026-10-23 10:38 JournalArticle 34777718 VALIDATED true Export Date: 14 February 2025 0 false 2026-10-09T16:42:49.393+0000 2024-11-28T06:11:25.495+0000 2024-04-08T16:27:24.530+0000 true 10014562 Temesvári Katalin /api/admin/10014562 Admin Temesvári Katalin (GKEM admin) true 10014562 2026-09-08T10:52:03.430+0000 2024-11-28T06:11:25.686+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Halász, H true true /api/journal/10051562 REVIEWED CELLS 2073-4409 true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 13 7 607 607 23 2024 Membrane nanotubes (NTs) are dynamic communication channels connecting spatially separated cells even over long distances and promoting the transport of different cellular cargos. NTs are also involved in the intercellular spread of different pathogens and the deterioration of some neurological disorders. Transport processes via NTs may be controlled by cytoskeletal elements. NTs are frequently observed membrane projections in numerous mammalian cell lines, including various immune cells, but their functional significance in the ‘antibody factory’ B cells is poorly elucidated. Here, we report that as active channels, NTs of B-lymphoma cells can mediate bidirectional mitochondrial transport, promoted by the cooperation of two different cytoskeletal motor proteins, kinesin along microtubules and myosin VI along actin, and bidirectional transport processes are also supported by the heterogeneous arrangement of the main cytoskeletal filament systems of the NTs. We revealed that despite NTs and axons being different cell extensions, the mitochondrial transport they mediate may exhibit significant similarities. Furthermore, we found that microtubules may improve the stability and lifespan of B-lymphoma-cell NTs, while F-actin strengthens NTs by providing a structural framework for them. Our results may contribute to a better understanding of the regulation of the major cells of humoral immune response to infections. Funding 2039969 /api/funding/2039969 GINOP(2.3.2-15-2016-00036) false true true true 2024 true true true false true false GOLD 2026-10-09 true https://doi.org/10.3390/cells13070607 14 0 14 13 0 14 14 13 13 14 14 13 13 13 1 0 14 13 14 13 0 5 5 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 4 3 4 3 2025 0 4 4 4 4 2026 0 6 6 6 6 Q1 false 10009982,10016613 false false false 2024-04-07T16:40:26.051+0000 Biofizikai Intézet (PTE / ÁOK) 4 15 1 5 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 116097955 /api/authorship/116097955 Halász, H [Halász, Henriett (Biofizika), szerző] Biofizikai Intézet (PTE / ÁOK) 1 0.2 true false false Author 10069063 /api/author/10069063 Halász Henriett (Biofizika) Halász Henriett true true Halász H true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116097956 /api/authorship/116097956 Tárnai, V [Tárnai, Viktória (Biofizika), szerző] Biofizikai Intézet (PTE / ÁOK) 2 0.2 false false false Author 10090563 /api/author/10090563 Tárnai Viktória (Biofizika) Tárnai Viktória true true Tárnai V true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116097957 /api/authorship/116097957 Matkó, J 3 0.2 false false false Matkó J true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116097958 /api/authorship/116097958 Nyitrai, M [Nyitrai, Miklós (Biofizika), szerző] Biofizikai Intézet (PTE / ÁOK) 4 0.2 false false false Author 10009982 /api/author/10009982 Nyitrai Miklós (Biofizika) Nyitrai Miklós true 10009982 true Nyitrai M true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116097959 /api/authorship/116097959 Szabó-Meleg, E ✉ [Szabó-Meleg, Edina (Biofizika), szerző] Biofizikai Intézet (PTE / ÁOK) 5 0.2 false true true Author 10016613 /api/author/10016613 Szabó-Meleg Edina (Biofizika) Szabó-Meleg Edina true 10016613 true Szabó-Meleg E true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 25973741 /api/publicationidentifier/25973741 DOI: 10.3390/cells13070607 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cells13070607 https://doi.org/10.3390/cells13070607 false true PublicationIdentifier 26041829 /api/publicationidentifier/26041829 WoS: 001200977200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001200977200001 https://www.webofscience.com/wos/woscc/full-record/001200977200001 false true PublicationIdentifier 26041828 /api/publicationidentifier/26041828 Scopus: 85190246528 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85190246528 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190246528 false true PublicationIdentifier 26026171 /api/publicationidentifier/26026171 PubMed: 38607046 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38607046 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38607046&dopt=Abstract false true SjrRating 11443701 /api/sjrrating/11443701 sjr:Q1 (2024) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) CELLS 2073-4409 40 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true Q1 DIRECT true true Reference 51733159 /api/reference/51733159 1. 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(2024) CELLS 2073-4409 13 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10069063"><a href="/gui2/?type=authors&mode=browse&sel=10069063" target="_blank">Halász H (<span class="authorship-author-name">Halász Henriett</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090563"><a href="/gui2/?type=authors&mode=browse&sel=10090563" target="_blank">Tárnai V (<span class="authorship-author-name">Tárnai Viktória</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matkó J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009982"><a href="/gui2/?type=authors&mode=browse&sel=10009982" target="_blank">Nyitrai M (<span class="authorship-author-name">Nyitrai Miklós</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016613"><a href="/gui2/?type=authors&mode=browse&sel=10016613" target="_blank">Szabó-Meleg E ✉ (<span class="authorship-author-name">Szabó-Meleg Edina</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34777718" target="_blank">Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">7</span> <span class="page"> Paper 607. 23 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells13070607" target="_blank" href="https://doi.org/10.3390/cells13070607"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001200977200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001200977200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85190246528" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190246528"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38607046" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38607046&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 13 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;14 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34777718&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34777718</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> GINOP(2.3.2-15-2016-00036) </div> <div class="lastModified">Utolsó módosítás: 2024.11.28. 07:11 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 14 February 2025</pre> </div></div>