https://m2.mtmt.hu/ eng 2026-08-26 13:48 JournalArticle 34774521 VALIDATED true 0 false 2026-06-10T23:22:08.041+0000 2024-11-13T13:20:37.136+0000 2024-04-07T08:20:37.544+0000 true 10012484 Pós Zoltán /api/author/10012484 Author Zoltán Pós (Immunológia) true 10012484 2026-03-06T11:35:04.500+0000 2024-07-31T16:22:22.065+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin Rita Tichy (SE_KK_Admin5_TR, admin) true 10026589 Admin 10067876 /api/admin/10067876 Gusztáv Ladányi (MTMT API user, admin) Ladányi Gusztáv true true Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2024-10-17T16:44:08.551+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Lupsa, Nikolett true true /api/journal/1504 REVIEWED EUROPEAN JOURNAL OF IMMUNOLOGY 0014-2980 1521-4141 true false 1504 false 1504 true 0014-2980 1521-4141 Journal FOREIGN 54 6 2350619 2350619 13 2024 This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin‐1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI‐aGvHD). Host CD4 + /CD25 hi /Foxp3 + Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA‐4, CD39, OX40, integrin‐β7, LAG3, TGFβ/LAP, granzyme‐A, ‐B, and interleukin‐10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none. Fluorescence‐activated cell sorter–sorted Treg subsets, displaying markers affected in a conditioning‐ and GI‐aGVHD‐restricted manner, were further investigated by transcriptome profiling and T‐cell suppression assays. We found that conditioning by irradiation greatly diminished the relative frequency of Helios + /Nrp1 + Treg, shifting the balance toward Helios − /Nrp1 − Treg in the host. Upregulation of integrin‐β7 and OX40 occurred in GI‐aGvHD‐dependent manner in Helios + /Nrp1 + cells but not in Helios − /Nrp1 − Treg. Sorted Treg subsets, confirmed to overexpress Nrp1, Helios, OX40, or integrin‐β7, displayed superior immunosuppressive activity and enrichment in activation‐related messenger RNA transcripts. Our data suggest that conditioning‐induced shrinkage of the Nrp1 + /Helios + Treg subset may contribute to the development of GI‐GvHD by impairing gut homing and decreasing the efficiency of Treg‐mediated immunosuppression. Funding 2038808 /api/funding/2038808 (131627) Funder: HSRF false true Funding 2038809 /api/funding/2038809 (FK 138842) false true true 2024 true true true false true false NONE 2026-06-11 false 1 0 1 1 0 1 1 1 0 1 1 1 1 1 0 0 1 1 1 1 0 2 2 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 Q1 false false false false 2024-07-06T08:20:38.812+0000 Biofizikai és Sejtbiológiai Intézet (DE / ÁOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HCEMM-SE Extracelluláris Vezikula Kutatócsoport (SE / AOK / I / GSII); MTA-SE Immun-proteogenomikai Extracelluláris Ve... (SE / AOK / I / GSII) 6 28 5 11 0 true 10014568 10067876 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 116062933 /api/authorship/116062933 Lupsa, Nikolett [Lupsa, Nikolett (immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 1 0.091 true false false Author 10036387 /api/author/10036387 Nikolett Lupsa (immunológia) Lupsa Nikolett true 10036387 true Lupsa Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062934 /api/authorship/116062934 Érsek, Barbara* [Molnár-Érsek, Barbara (immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 2 0.091 true false false Author 10031103 /api/author/10031103 Barbara Molnár-Érsek (immunológia) Molnár-Érsek Barbara true 10031103 true Érsek Barbara true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062935 /api/authorship/116062935 Böröczky, Csenge 3 0.09090909 false false false Böröczky Csenge true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062936 /api/authorship/116062936 Kis, Dávid 4 0.09090909 false false false Kis Dávid true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062937 /api/authorship/116062937 Szarka, Eszter 5 0.09090909 false false false Szarka Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062938 /api/authorship/116062938 Lumniczky, Katalin 6 0.09090909 false false false Lumniczky Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062939 /api/authorship/116062939 Sáfrány, Géza 7 0.09090909 false false false Sáfrány Géza true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062940 /api/authorship/116062940 Zádori, Zoltán S [Zádori, Zoltán Sándor (Farmakológia, gas...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 8 0.091 false false false Author 10017488 /api/author/10017488 Zoltán Sándor Zádori (Farmakológia, gasztrointesztinális farmakológia) Zádori Zoltán Sándor true 10017488 true Zádori Zoltán S true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062941 /api/authorship/116062941 Szöőr, Árpád [Szöőr, Árpád (orvostudomány), author] Department of Biophysics and Cell Biology (UD) 9 0.09090909 false false false Author 10034414 /api/author/10034414 Árpád Szöőr (orvostudomány) Szöőr Árpád true 10034414 true Szöőr Árpád true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062942 /api/authorship/116062942 Buzás, Edit I [Buzás, Edit Irén (Immunbiológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I); MTA-SE Immune-Proteogenomics Extracellular Vesi... (SU / FM / I / DGCI); HCEMM-SU Extracellular Vesicles Research Group (SU / FM / I / DGCI) 10 0.091 false false false Author 10015596 /api/author/10015596 Edit Irén Buzás (Immunbiológia) Buzás Edit Irén true 10015596 true Buzás Edit I true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 116062943 /api/authorship/116062943 Pós, Zoltán ✉ [Pós, Zoltán (Immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 11 0.091 false true true Author 10012484 /api/author/10012484 Zoltán Pós (Immunológia) Pós Zoltán true 10012484 true Pós Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25964727 /api/publicationidentifier/25964727 DOI: 10.1002/eji.202350619 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1002/eji.202350619 https://doi.org/10.1002/eji.202350619 false true PublicationIdentifier 25964729 /api/publicationidentifier/25964729 WoS: 001190927300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001190927300001 https://www.webofscience.com/wos/woscc/full-record/001190927300001 false true PublicationIdentifier 26023417 /api/publicationidentifier/26023417 Scopus: 85189564443 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85189564443 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85189564443 false true PublicationIdentifier 25999712 /api/publicationidentifier/25999712 PubMed: 38532599 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38532599 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38532599&dopt=Abstract false true SjrRating 11472263 /api/sjrrating/11472263 sjr:Q1 (2024) Scopus - Immunology EUROPEAN JOURNAL OF IMMUNOLOGY 0014-2980 1521-4141 39 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 Scopus - Immunology true 2403 true Q1 DIRECT true true Reference 51694422 /api/reference/51694422 1. 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(2024) EUROPEAN JOURNAL OF IMMUNOLOGY 0014-2980 1521-4141 54 6<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10036387"><a href="/gui2/?type=authors&mode=browse&sel=10036387" target="_blank">Lupsa Nikolett (<span class="authorship-author-name">Lupsa Nikolett</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031103"><a href="/gui2/?type=authors&mode=browse&sel=10031103" target="_blank">Érsek Barbara^* (<span class="authorship-author-name">Molnár-Érsek Barbara</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Böröczky Csenge </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kis Dávid </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szarka Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lumniczky Katalin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sáfrány Géza </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017488"><a href="/gui2/?type=authors&mode=browse&sel=10017488" target="_blank">Zádori Zoltán S (<span class="authorship-author-name">Zádori Zoltán Sándor</span> <span class="authorAux-mtmt"> Farmakológia, gasztrointesztinális farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034414"><a href="/gui2/?type=authors&mode=browse&sel=10034414" target="_blank">Szöőr Árpád (<span class="authorship-author-name">Szöőr Árpád</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biophysics and Cell Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015596"><a href="/gui2/?type=authors&mode=browse&sel=10015596" target="_blank">Buzás Edit I (<span class="authorship-author-name">Buzás Edit Irén</span> <span class="authorAux-mtmt"> Immunbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Genetics, Cell- and Immunology">DGCI</span>/MTA-SE Immune-Proteogenomics Extracellular Vesicle Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Genetics, Cell- and Immunology">DGCI</span>/HCEMM-SU Extracellular Vesicles Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012484"><a href="/gui2/?type=authors&mode=browse&sel=10012484" target="_blank">Pós Zoltán ✉ (<span class="authorship-author-name">Pós Zoltán</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34774521" target="_blank">High sensitivity of host Helios + /Neuropilin‐1 + Treg to pretransplant conditioning hampers development of OX40 bright /integrin‐β7 + regulatory cells in acute gastrointestinal GvHD</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0014-2980">0014-2980</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-4141">1521-4141</a>)</span>: <span class="journal-volume">54</span> <span class="journal-issue">6</span> <span class="page"> Paper 2350619. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/eji.202350619" target="_blank" href="https://doi.org/10.1002/eji.202350619"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001190927300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001190927300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85189564443" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85189564443"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38532599" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38532599&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Immunology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34774521&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34774521</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (131627) Funder: HSRF, (FK 138842) </div> <div class="lastModified">Last Modified: 2024.11.13. 14:20 Nikolett Szabó-Szentesi (DE/ÁOK/BSI, MTA-DESJKCS admin 5) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:44 Gusztáv Ladányi (MTMT API user, admin) Andrea Vándor (VA, admin) </div> </div></div>