https://m2.mtmt.hu/ hun 2026-09-21 16:49 JournalArticle 34773870 VALIDATED true Funding Agency and Grant Number: American Heart Association Funding text: No Statement Available 0 false 2026-08-03T11:26:18.133+0000 2024-12-06T18:08:15.305+0000 2024-04-06T09:28:10.620+0000 true 10080371 Major Dávid /api/author/10080371 Author Major Dávid (Megelőző orvostan, társadalomegészségtan) true 2026-01-22T15:32:28.536+0000 2024-12-06T18:08:15.693+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2025-06-04T23:43:15.174+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Balasubramanian, Priya true true /api/journal/10016563 REVIEWED NUTRIENTS 2072-6643 true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 16 7 952 952 18 2024 High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay of HFD, obesity, and diabetes expedites the aging process and prematurely fosters age-related diseases. However, the underlying mechanisms driving these associations remain enigmatic. One of the most conspicuous hallmarks of aging is the accumulation of highly inflammatory senescent cells, with mounting evidence implicating increased cellular senescence in the pathogenesis of age-related diseases. Our hypothesis posits that HFD consumption amplifies senescence burden across multiple organs. To scrutinize this hypothesis, we subjected mice to a 6-month HFD regimen, assessing senescence biomarker expression in the liver, white adipose tissue, and the brain. Aging is intrinsically linked to impaired cellular stress resilience, driven by dysfunction in Nrf2-mediated cytoprotective pathways that safeguard cells against oxidative stress-induced senescence. To ascertain whether Nrf2-mediated pathways shield against senescence induction in response to HFD consumption, we explored senescence burden in a novel model of aging: Nrf2-deficient (Nrf2+/−) mice, emulating the aging phenotype. Our initial findings unveiled significant Nrf2 dysfunction in Nrf2+/− mice, mirroring aging-related alterations. HFD led to substantial obesity, hyperglycemia, and impaired insulin sensitivity in both Nrf2+/− and Nrf2+/+ mice. In control mice, HFD primarily heightened senescence burden in white adipose tissue, evidenced by increased Cdkn2a senescence biomarker expression. In Nrf2+/− mice, HFD elicited a significant surge in senescence burden across the liver, white adipose tissue, and the brain. We postulate that HFD-induced augmentation of senescence burden may be a pivotal contributor to accelerated organismal aging and the premature onset of age-related diseases. true 2024 true true true false true false GOLD 2026-08-03 false http://www.mdpi.com/journal/nutrients/ 36 0 36 32 5 36 36 33 34 36 36 32 32 32 4 0 36 32 36 32 0 23 23 Folyóiratcikk Journal Article 24 35 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 5 5 5 5 2025 0 21 18 21 18 2026 0 10 9 10 9 D1 false false false false 2024-04-23T11:45:40.573+0000 ELKH-SE Cerebrovaszkuláris és Neurokognitív Bet... (SE / AOK / I / TMI); Gyermekgyógyászati Klinika (SE / AOK / K) 5 41 2 8 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 116045315 /api/authorship/116045315 Balasubramanian, Priya 1 0.125 true false false Balasubramanian Priya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045316 /api/authorship/116045316 Kiss, Tamas [Kiss, Tamás (bioinformatika), szerző] ELKH-SE Cerebrovaszkuláris és Neurokognitív Bet... (SE / AOK / I / TMI); Gyermekgyógyászati Klinika (SE / AOK / K) 2 0.125 false false false Author 10071509 /api/author/10071509 Kiss Tamás (bioinformatika) Kiss Tamás true true Kiss Tamas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045317 /api/authorship/116045317 Gulej, Rafal 3 0.125 false false false Gulej Rafal true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045318 /api/authorship/116045318 Nyul Toth, Adam [Nyúl-Tóth, Ádám (biofizika), szerző] 4 0.125 false false false Author 10045003 /api/author/10045003 Nyúl-Tóth Ádám (biofizika) Nyúl-Tóth Ádám true 10045003 true Nyul Toth Adam true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045319 /api/authorship/116045319 Tarantini, Stefano [Tarantini, Stefano (népegészségtan, g...), szerző] 5 0.125 false false false Author 10074557 /api/author/10074557 Tarantini Stefano (népegészségtan, gerontológia, molekuláris biológia, kórélettan) Tarantini Stefano true true Tarantini Stefano true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045320 /api/authorship/116045320 Yabluchanskiy, Andriy 6 0.125 false false false Yabluchanskiy Andriy true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045321 /api/authorship/116045321 Ungvari, Zoltan ✉ [Ungvári, Zoltán István (Orvostudomány, me...), szerző] ELKH-SE Cerebrovaszkuláris és Neurokognitív Bet... (SE / AOK / I / TMI) 7 0.125 false false true Author 10043602 /api/author/10043602 Ungvári Zoltán István (Orvostudomány, megelőző orvostan, népegészségtan, kórélettan, gerontológia) Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 116045322 /api/authorship/116045322 Csiszar, Anna [Csiszar, Anna (Orvostudomany), szerző] ELKH-SE Cerebrovaszkuláris és Neurokognitív Bet... (SE / AOK / I / TMI) 8 0.125 false true false Author 10071157 /api/author/10071157 Csiszar Anna (Orvostudomany) Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 25963140 /api/publicationidentifier/25963140 DOI: 10.3390/nu16070952 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/nu16070952 https://doi.org/10.3390/nu16070952 false true PublicationIdentifier 26161888 /api/publicationidentifier/26161888 WoS: 001201035600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001201035600001 https://www.webofscience.com/wos/woscc/full-record/001201035600001 true true PublicationIdentifier 26081747 /api/publicationidentifier/26081747 Scopus: 85190491451 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85190491451 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190491451 true true PublicationIdentifier 26081759 /api/publicationidentifier/26081759 PubMed: 38612986 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38612986 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38612986&dopt=Abstract true true SjrRating 11464918 /api/sjrrating/11464918 sjr:D1 (2024) Scopus - Food Science NUTRIENTS 2072-6643 23 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 Scopus - Food Science true 1106 true D1 DIRECT true true Reference 51679167 /api/reference/51679167 1. 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(2024) NUTRIENTS 2072-6643 16 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Balasubramanian Priya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss Tamas (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gulej Rafal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyul Toth Adam (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy Andriy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan ✉ (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34773870" target="_blank">Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">7</span> <span class="page"> Paper 952. 18 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/nu16070952" target="_blank" href="https://doi.org/10.3390/nu16070952"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001201035600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001201035600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85190491451" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85190491451"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38612986" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38612986&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 36</span> | Független: 32 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 33 | Scopus jelölt:&nbsp;34 | WoS/Scopus jelölt:&nbsp;36 | DOI jelölt:&nbsp;36 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34773870&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34773870</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 19:08 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.06.05. 01:43 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: American Heart Association Funding text: No Statement Available</pre> </div></div>