https://m2.mtmt.hu/ hun 2026-10-24 12:57 JournalArticle 34763944 VALIDATED true * Megosztott szerzőség 0 false 2026-10-24T09:30:56.600+0000 2024-11-27T17:06:24.025+0000 2024-04-02T08:54:58.145+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-02-26T14:10:15.367+0000 2024-05-14T07:36:09.304+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:26:56.639+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Rosano, Dalia Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells true true /api/journal/10022922 REVIEWED true false 10022922 false 10022922 true 2159-8274 2159-8290 Journal FOREIGN 14 5 866 889 866 24 2024 Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late relapse patients and longitudinally profiled a rare cohort treated with long-term neoadjuvant ETs until progression. Next, we developed an in vitro evolutionary study to record the adaptive strategies of individual lineages in unperturbed parallel experiments. Our data demonstrate that ETs induce nongenetic cell state transitions into dormancy in a stochastic subset of cells via epigenetic reprogramming. Single lineages with divergent phenotypes awaken unpredictably in the absence of recurrent genetic alterations. Targeting the dormant epigenome shows promising activity against adapting cancer cells. Overall, this study uncovers the contribution of epigenetic adaptation to the evolution of resistance to ETs.This study advances the understanding of therapy-induced dormancy with potential clinical implications for breast cancer. Estrogen receptor-positive breast cancer cells adapt to endocrine treatment by entering a dormant state characterized by strong heterochromatinization with no recurrent genetic changes. 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0.03846154 false false false Cresswell George D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115979446 /api/authorship/115979446 22 0.03846154 false false false Rehman Farah true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115979447 /api/authorship/115979447 23 0.03846154 false false false Noberini Roberta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115979448 /api/authorship/115979448 24 0.03846154 false false false Bonaldi Tiziana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115979449 /api/authorship/115979449 25 0.03846154 false false false Sottoriva Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115979450 /api/authorship/115979450 26 0.038 false true true Magnani Luca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25929725 /api/publicationidentifier/25929725 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1158/2159-8290.CD-23-1161 https://doi.org/10.1158/2159-8290.CD-23-1161 false true PublicationIdentifier 26209615 /api/publicationidentifier/26209615 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001225915900003 https://www.webofscience.com/wos/woscc/full-record/001225915900003 false true PublicationIdentifier 26176150 /api/publicationidentifier/26176150 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85192028803 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192028803 false true PublicationIdentifier 25929724 /api/publicationidentifier/25929724 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38527495 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38527495&dopt=Abstract false true SjrRating 11488801 /api/sjrrating/11488801 13 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true D1 DIRECT true true /api/publication/34763944 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Rosano Dalia ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sofyali Emre<sup>*</sup> ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dhiman Heena<sup>*</sup> ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ghirardi Chiara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ivanoiu Diana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heide Timon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vingiani Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bertolotti Alessia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pruneri Giancarlo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Canale Eleonora </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dewhurst Hannah F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Saha Debjani </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Slaven Neil </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barozzi Iros </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li Tong </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zemlyanskiy Grigory </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Phillips Henry </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >James Chela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület); <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lynn Claire </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cresswell George D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rehman Farah </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Noberini Roberta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bonaldi Tiziana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sottoriva Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Magnani Luca ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34763944" target="_blank">Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells</a></div> <div> <span class="journal-title">CANCER DISCOVERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2159-8274">2159-8274</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2159-8290">2159-8290</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">5</span> <span class="page"> pp 866-889 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1158/2159-8290.CD-23-1161" target="_blank" href="https://doi.org/10.1158/2159-8290.CD-23-1161"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001225915900003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001225915900003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85192028803" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192028803"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38527495" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38527495&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 59</span> | Független: 57 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 56 | Scopus jelölt:&nbsp;49 | WoS/Scopus jelölt:&nbsp;59 | DOI jelölt:&nbsp;59 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34763944&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34763944</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.27. 18:06 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:26 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>