https://m2.mtmt.hu/ hun 2026-09-22 19:00 JournalArticle 34758725 VALIDATED true Cited By :2 Export Date: 6 March 2025 CODEN: BCSTB Correspondence Address: Chinopoulos, C.; Department of Biochemistry, Hungary; email: chinopoulos.christos@semmelweis.hu 0 false 2026-09-07T09:00:18.768+0000 2026-02-02T11:52:37.992+0000 2024-03-27T12:02:36.632+0000 true 10000059 Kolev Kraszimir Nikolaev /api/author/10000059 Author Kolev Kraszimir Nikolaev (Orvosi biokémia) true 10000059 2026-05-18T02:42:33.398+0000 2024-12-11T12:36:44.419+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Csajbók Edit (SE_KK_Admin5_CSE, admin) true 10015544 2025-12-08T19:34:47.688+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Csajbók Edit (SE_KK_Admin5_CSE, admin) true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Chinopoulos, Christos true true /api/journal/2016699 REVIEWED BIOCHEMICAL SOCIETY TRANSACTIONS 0300-5127 1470-8752 true false 2016699 false 2016699 true 0300-5127 1470-8752 Journal FOREIGN 52 2 529 538 529 10 2024 Certain cancer cells within solid tumors experience hypoxia, rendering them incapable of oxidative phosphorylation (OXPHOS). Despite this oxygen deficiency, these cells exhibit biochemical pathway activity that relies on NAD+. This mini-review scrutinizes the persistent, residual Complex I activity that oxidizes NADH in the absence of oxygen as the electron acceptor. The resulting NAD+ assumes a pivotal role in fueling the α-ketoglutarate dehydrogenase complex, a critical component in the oxidative decarboxylation branch of glutaminolysis — a hallmark oncometabolic pathway. The proposition is that through glutamine catabolism, high-energy phosphate intermediates are produced via substrate-level phosphorylation in the mitochondrial matrix substantiated by succinyl-CoA ligase, partially compensating for an OXPHOS deficiency. These insights provide a rationale for exploring Complex I inhibitors in cancer treatment, even when OXPHOS functionality is already compromised. true true 2024 true true true false true false NONE 2026-09-07 false 3 0 3 2 1 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 13 13 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 1 0 1 0 Q1 false false false false 2024-04-04T08:47:49.360+0000 Biokémiai Tanszék (SE / AOK / I / BMBI) 1 9 1 1 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 115931887 /api/authorship/115931887 Chinopoulos, Christos ✉ [Chinopoulos, Christos (Bioenergetika), szerző] Biokémiai Tanszék (SE / AOK / I / BMBI) 1 1.0 true false true Author 10016754 /api/author/10016754 Chinopoulos Christos (Bioenergetika) Chinopoulos Christos true 10016754 true Chinopoulos Christos true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 25917463 /api/publicationidentifier/25917463 DOI: 10.1042/BST20230189 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1042/BST20230189 https://doi.org/10.1042/BST20230189 false true PublicationIdentifier 25934540 /api/publicationidentifier/25934540 WoS: 001190691200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001190691200001 https://www.webofscience.com/wos/woscc/full-record/001190691200001 true true PublicationIdentifier 26136151 /api/publicationidentifier/26136151 Scopus: 85191614761 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85191614761 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85191614761 true true PublicationIdentifier 25958865 /api/publicationidentifier/25958865 PubMed: 38526218 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38526218 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38526218&dopt=Abstract true true PublicationIdentifier 31331785 /api/publicationidentifier/31331785 Egyéb URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191614761&doi=10.1042%2FBST20230189&partnerID=40&md5=a3047ea3d7af2fe302baa4c036e1d455 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191614761&doi=10.1042%2FBST20230189&partnerID=40&md5=a3047ea3d7af2fe302baa4c036e1d455 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191614761&doi=10.1042%2FBST20230189&partnerID=40&md5=a3047ea3d7af2fe302baa4c036e1d455 false true SjrRating 11443287 /api/sjrrating/11443287 sjr:Q1 (2024) Scopus - Biochemistry BIOCHEMICAL SOCIETY TRANSACTIONS 0300-5127 1470-8752 49 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 Scopus - Biochemistry true 1303 true Q1 DIRECT true true Reference 51400409 /api/reference/51400409 1. 2011: Hallmarks of cancer: the next generation., Cell, 144, p. 646, DOI: 10.1016/j.cell.2011.02.013 1 10.1016/j.cell.2011.02.013 false true Reference 51400410 /api/reference/51400410 2. 1923: Versuche an Überlebendem Carcinom-gewebe., Klin. Wochenschr., 2, p. 776, DOI: 10.1007/BF01712130 2 10.1007/BF01712130 false true Reference 51400411 /api/reference/51400411 3. 2020: SLC25A51 is a mammalian mitochondrial NAD(+) transporter., Nature, 588, p. 174, DOI: 10.1038/s41586-020-2741-7 3 10.1038/s41586-020-2741-7 false true Reference 51400412 /api/reference/51400412 4. 2020: Acute sources of mitochondrial NAD(+) during respiratory chain dysfunction., Exp. Neurol., 327, p. 113218, DOI: 10.1016/j.expneurol.2020.113218 4 10.1016/j.expneurol.2020.113218 false true Reference 51400413 /api/reference/51400413 5. 2004: Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response., Oncologist, 9, p. 4, DOI: 10.1634/theoncologist.9-90005-4 5 10.1634/theoncologist.9-90005-4 false true Reference 51400414 /api/reference/51400414 6. 2019: Hypoxia-modified cancer cell metabolism., Front. Cell Dev. Biol., 7, p. 4, DOI: 10.3389/fcell.2019.00004 6 10.3389/fcell.2019.00004 false true Reference 51400415 /api/reference/51400415 7. 2020: On the origin of ATP synthesis in cancer., iScience, 23, p. 101761, DOI: 10.1016/j.isci.2020.101761 7 10.1016/j.isci.2020.101761 false true Reference 51400416 /api/reference/51400416 8. 2011: Genetic insights into OXPHOS defect and its role in cancer., Biochim. Biophys. Acta, 1807, p. 620, DOI: 10.1016/j.bbabio.2010.10.023 8 10.1016/j.bbabio.2010.10.023 false true Reference 51400417 /api/reference/51400417 9. 2018: Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy., J. Clin. Invest., 128, p. 3682, DOI: 10.1172/JCI120844 9 10.1172/JCI120844 false true Reference 51400418 /api/reference/51400418 10. 2012: Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (Review)., Oncol. Lett., 4, p. 1151, DOI: 10.3892/ol.2012.928 10 10.3892/ol.2012.928 false true Reference 51400419 /api/reference/51400419 11. 2011: Oxidative phosphorylation in cancer cells., Biochim. Biophys. Acta, 1807, p. 534, DOI: 10.1016/j.bbabio.2010.09.003 11 10.1016/j.bbabio.2010.09.003 false true Reference 51400420 /api/reference/51400420 12. 2023: Viability of HepG2 and MCF-7 cells is not correlated with mitochondrial bioenergetics., Sci. Rep., 13, p. 10822, DOI: 10.1038/s41598-023-37677-x 12 10.1038/s41598-023-37677-x false true Reference 51400421 /api/reference/51400421 13. 2016: Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency., Nat. Commun., 7, p. 12317, DOI: 10.1038/ncomms12317 13 10.1038/ncomms12317 false true Reference 51400422 /api/reference/51400422 14. 2018: An inhibitor of oxidative phosphorylation exploits cancer vulnerability., Nat. Med., 24, p. 1036, DOI: 10.1038/s41591-018-0052-4 14 10.1038/s41591-018-0052-4 false true Reference 51400423 /api/reference/51400423 15. 2013: BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I., Cancer Med., 2, p. 611, DOI: 10.1002/cam4.112 15 10.1002/cam4.112 false true Reference 51400424 /api/reference/51400424 16. 2014: Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis., Elife, 3, p. e02242, DOI: 10.7554/eLife.02242 16 10.7554/eLife.02242 false true Reference 51400425 /api/reference/51400425 17. 2020: The mitochondrion as an emerging therapeutic target in cancer., Trends Mol. Med., 26, p. 119, DOI: 10.1016/j.molmed.2019.06.009 17 10.1016/j.molmed.2019.06.009 false true Reference 51400426 /api/reference/51400426 18. 2020: Targeting mitochondrial complex I overcomes chemoresistance in high OXPHOS pancreatic cancer., Cell Rep. Med., 1, p. 100143, DOI: 10.1016/j.xcrm.2020.100143 18 10.1016/j.xcrm.2020.100143 false true Reference 51400427 /api/reference/51400427 19. 2021: Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment., iScience, 24, p. 103497, DOI: 10.1016/j.isci.2021.103497 19 10.1016/j.isci.2021.103497 false true Reference 51400428 /api/reference/51400428 20. 2022: Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies., FEBS J., 289, p. 8003, DOI: 10.1111/febs.16218 20 10.1111/febs.16218 false true Reference 51400429 /api/reference/51400429 21. 2021: Targeting the complex I and III of mitochondrial electron transport chain as a potentially viable option in liver cancer management., Cell Death Discov., 7, p. 293, DOI: 10.1038/s41420-021-00675-x 21 10.1038/s41420-021-00675-x false true Reference 51400430 /api/reference/51400430 22. 2023: Recent advances of mitochondrial complex I inhibitors for cancer therapy: current status and future perspectives., Eur. J. Med. Chem., 251, p. 115219, DOI: 10.1016/j.ejmech.2023.115219 22 10.1016/j.ejmech.2023.115219 false true Reference 51400431 /api/reference/51400431 23. 2019: Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses., Nat. Commun., 10, p. 903, DOI: 10.1038/s41467-019-08839-1 23 10.1038/s41467-019-08839-1 false true Reference 51400432 /api/reference/51400432 24. 2013: Suppression of mitochondrial complex I influences cell metastatic properties., PLoS One, 8, p. e61677, DOI: 10.1371/journal.pone.0061677 24 10.1371/journal.pone.0061677 false true Reference 51400433 /api/reference/51400433 25. 2017: The mitochondrial complex(I)ty of cancer., Front. Oncol., 7, p. 118, DOI: 10.3389/fonc.2017.00118 25 10.3389/fonc.2017.00118 false true Reference 51400434 /api/reference/51400434 26. 2011: A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function., Cancer Res., 71, p. 6220, DOI: 10.1158/0008-5472.CAN-11-1042 26 10.1158/0008-5472.CAN-11-1042 false true Reference 51400435 /api/reference/51400435 27. 2014: Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment., Hum. Mol. Genet., 23, p. 1453, DOI: 10.1093/hmg/ddt533 27 10.1093/hmg/ddt533 false true Reference 51400436 /api/reference/51400436 28. 2009: A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis., Hum. Mol. Genet., 18, p. 1578, DOI: 10.1093/hmg/ddp069 28 10.1093/hmg/ddp069 false true Reference 51400437 /api/reference/51400437 29. 2008: ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis., Science, 320, p. 661, DOI: 10.1126/science.1156906 29 10.1126/science.1156906 false true Reference 51400438 /api/reference/51400438 30. 2023: Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials., Nat. Med., 29, p. 115, DOI: 10.1038/s41591-022-02103-8 30 10.1038/s41591-022-02103-8 false true Reference 51400439 /api/reference/51400439 31. 2013: Mitochondrial complex I., Annu. Rev. Biochem., 82, p. 551, DOI: 10.1146/annurev-biochem-070511-103700 31 10.1146/annurev-biochem-070511-103700 false true Reference 51400440 /api/reference/51400440 32. 2023: Gotenzymes: an extensive database of enzyme parameter predictions., Nucleic Acids Res., 51, p. D583, DOI: 10.1093/nar/gkac831 32 10.1093/nar/gkac831 false true Reference 51400441 /api/reference/51400441 33. 2014: Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters., Biochim. Biophys. Acta, 1842, p. 2510, DOI: 10.1016/j.bbadis.2013.04.027 33 10.1016/j.bbadis.2013.04.027 false true Reference 51400442 /api/reference/51400442 34. 1959: The effect of alpha-tocopherol, alpha-tocopherylhydroquinone and their esters on experimental muscular dystrophy in the rat., J. Nutr., 67, p. 223, DOI: 10.1093/jn/67.2.223 34 10.1093/jn/67.2.223 false true Reference 51400443 /api/reference/51400443 35. 1997: Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids., Proc. Natl Acad. Sci. U.S.A., 94, p. 7885, DOI: 10.1073/pnas.94.15.7885 35 10.1073/pnas.94.15.7885 false true Reference 51400444 /api/reference/51400444 36. 1973: Oxidation-reduction potential of the ferro-ferricyanide system in buffer solutions., Biochim. Biophys. Acta, 292, p. 509, DOI: 10.1016/0005-2728(73)90001-7 36 10.1016/0005-2728(73)90001-7 false true Reference 51400445 /api/reference/51400445 37. 2019: Tuning the formal potential of ferrocyanide over a 2.1V range., Chem. Sci., 10, p. 3623, DOI: 10.1039/C8SC04972F 37 10.1039/C8SC04972F false true Reference 51400446 /api/reference/51400446 38. 2014: Mitochondrial diaphorases as NAD(+) donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition., FASEB J., 28, p. 1682, DOI: 10.1096/fj.13-243030 38 10.1096/fj.13-243030 false true Reference 51400447 /api/reference/51400447 39. 2010: Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation., FASEB J., 24, p. 2405, DOI: 10.1096/fj.09-149898 39 10.1096/fj.09-149898 false true Reference 51400448 /api/reference/51400448 40. 2011: Mitochondrial consumption of cytosolic ATP: not so fast., FEBS Lett., 585, p. 1255, DOI: 10.1016/j.febslet.2011.04.004 40 10.1016/j.febslet.2011.04.004 false true Reference 51400449 /api/reference/51400449 41. 2011: The “B space” of mitochondrial phosphorylation., J. Neurosci. Res., 89, p. 1897, DOI: 10.1002/jnr.22659 41 10.1002/jnr.22659 false true Reference 51400450 /api/reference/51400450 42. 2008: Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers., Free Radic. Biol. Med., 44, p. 835, DOI: 10.1016/j.freeradbiomed.2007.11.013 42 10.1016/j.freeradbiomed.2007.11.013 false true Reference 51400451 /api/reference/51400451 43. 2000: Blue copper proteins: a comparative analysis of their molecular interaction properties., Protein Sci., 9, p. 1439, DOI: 10.1110/ps.9.8.1439 43 10.1110/ps.9.8.1439 false true Reference 51400452 /api/reference/51400452 44. 2016: Design and fine-tuning redox potentials of metalloproteins involved in electron transfer in bioenergetics., Biochim. Biophys. Acta, 1857, p. 557, DOI: 10.1016/j.bbabio.2015.08.006 44 10.1016/j.bbabio.2015.08.006 false true Reference 51400453 /api/reference/51400453 45. 2018: Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD(+) supports substrate-level phosphorylation during respiratory inhibition., Biochim. Biophys. Acta Bioenerg., 1859, p. 909, DOI: 10.1016/j.bbabio.2018.05.002 45 10.1016/j.bbabio.2018.05.002 false true Reference 51400454 /api/reference/51400454 46. 2023: Complex II ambiguities-FADH(2) in the electron transfer system., J. Biol. Chem., 300, p. 105470, DOI: 10.1016/j.jbc.2023.105470 46 10.1016/j.jbc.2023.105470 false true Reference 51400455 /api/reference/51400455 47. 2019: Succinate in ischemia: where does it come from?., Int. J. Biochem. Cell Biol., 115, p. 105580, DOI: 10.1016/j.biocel.2019.105580 47 10.1016/j.biocel.2019.105580 false true Reference 51400456 /api/reference/51400456 48. 2018: Accumulation of succinate in cardiac ischemia primarily occurs via canonical krebs cycle activity., Cell Rep., 23, p. 2617, DOI: 10.1016/j.celrep.2018.04.104 48 10.1016/j.celrep.2018.04.104 false true Reference 51400457 /api/reference/51400457 49. 2024: Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia., Sci. Rep., 14, p. 1729, DOI: 10.1038/s41598-024-51365-4 49 10.1038/s41598-024-51365-4 false true Reference 51400458 /api/reference/51400458 50. 2021: Fumarate is a terminal electron acceptor in the mammalian electron transport chain., Science, 374, p. 1227, DOI: 10.1126/science.abi7495 50 10.1126/science.abi7495 false true Reference 51400459 /api/reference/51400459 51. 2020: Regulation of succinate dehydrogenase and role of succinate in cancer., Semin Cell Dev. Biol., 98, p. 4, DOI: 10.1016/j.semcdb.2019.04.013 51 10.1016/j.semcdb.2019.04.013 false true Reference 51400460 /api/reference/51400460 52. 1967: The inhibition of succinate dehydrogenase by oxaloacetate., Biochim. Biophys. Acta, 132, p. 210, DOI: 10.1016/0005-2744(67)90214-8 52 10.1016/0005-2744(67)90214-8 false true Reference 51400461 /api/reference/51400461 53. 2022: The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology., FEBS J., 289, p. 6936, DOI: 10.1111/febs.16164 53 10.1111/febs.16164 false true Reference 51400462 /api/reference/51400462 54. 2020: The SLC25 carrier family: important transport proteins in mitochondrial physiology and pathology., Physiology (Bethesda), 35, p. 302, DOI: 10.1152/physiol.00009.2020 54 10.1152/physiol.00009.2020 false true Reference 51400463 /api/reference/51400463 55. 1955: Nutrition needs of mammalian cells in tissue culture., Science, 122, p. 501, DOI: 10.1126/science.122.3168.501 55 10.1126/science.122.3168.501 false true Reference 51400464 /api/reference/51400464 56. 2010: Glutamine addiction: a new therapeutic target in cancer., Trends Biochem. Sci., 35, p. 427, DOI: 10.1016/j.tibs.2010.05.003 56 10.1016/j.tibs.2010.05.003 false true Reference 51400465 /api/reference/51400465 57. 2017: Glutaminolysis: a hallmark of cancer metabolism., Annu. Rev. Biomed. Eng., 19, p. 163, DOI: 10.1146/annurev-bioeng-071516-044546 57 10.1146/annurev-bioeng-071516-044546 false true Reference 51400466 /api/reference/51400466 58. 2018: Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis., ASN Neuro, 10, p. 1759091418818261, DOI: 10.1177/1759091418818261 58 10.1177/1759091418818261 false true Reference 51400467 /api/reference/51400467 59. 2020: An atlas of human metabolism., Sci. Signal., 13, p. eaaz1482, DOI: 10.1126/scisignal.aaz1482 59 10.1126/scisignal.aaz1482 false true Reference 51400468 /api/reference/51400468 60. 2016: Novel drugs that target the metabolic reprogramming in renal cell cancer., Cancer Metab., 4, p. 14, DOI: 10.1186/s40170-016-0154-8 60 10.1186/s40170-016-0154-8 false true Reference 51400469 /api/reference/51400469 61. 2017: A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: the WarburQ effect., PLoS Comput. Biol., 13, p. e1005758, DOI: 10.1371/journal.pcbi.1005758 61 10.1371/journal.pcbi.1005758 false true Reference 51400470 /api/reference/51400470 62. 2016: Reductive carboxylation supports redox homeostasis during anchorage-independent growth., Nature, 532, p. 255, DOI: 10.1038/nature17393 62 10.1038/nature17393 false true Reference 51400471 /api/reference/51400471 63. 2015: Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis., J. Clin. Invest., 125, p. 1174, DOI: 10.1172/JCI76029 63 10.1172/JCI76029 false true Reference 51400472 /api/reference/51400472 64. 2019: Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells., Nat. Commun., 10, p. 1351, DOI: 10.1038/s41467-019-09352-1 64 10.1038/s41467-019-09352-1 false true Reference 51400473 /api/reference/51400473 65. 1998: Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes., J. Biol. Chem., 273, p. 27580, DOI: 10.1074/jbc.273.42.27580 65 10.1074/jbc.273.42.27580 false true Reference 51400474 /api/reference/51400474 66. 2004: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues., J. Biol. Chem., 279, p. 36621, DOI: 10.1074/jbc.M406884200 66 10.1074/jbc.M406884200 false true Reference 51400475 /api/reference/51400475 67. 2016: Two transgenic mouse models for beta-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations., Biochem. J., 473, p. 3463, DOI: 10.1042/BCJ20160594 67 10.1042/BCJ20160594 false true Reference 51400476 /api/reference/51400476 68. 2014: Characterisation of the active/de-active transition of mitochondrial complex I., Biochim. Biophys. Acta, 1837, p. 1083, DOI: 10.1016/j.bbabio.2014.02.018 68 10.1016/j.bbabio.2014.02.018 false true Reference 51400477 /api/reference/51400477 69. 2013: Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I., Biochem. Soc. Trans., 41, p. 1325, DOI: 10.1042/BST20130088 69 10.1042/BST20130088 false true Reference 51400478 /api/reference/51400478 70. 2024: Association of 2-oxoacid dehydrogenase complexes with respirasomes in mitochondria., FEBS J., 291, p. 132, DOI: 10.1111/febs.16965 70 10.1111/febs.16965 false true /api/publication/34758725 Chinopoulos Christos. Complex I activity in hypoxia: implications for oncometabolism. (2024) BIOCHEMICAL SOCIETY TRANSACTIONS 0300-5127 1470-8752 52 2 529-538<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10016754"><a href="/gui2/?type=authors&mode=browse&sel=10016754" target="_blank">Chinopoulos Christos ✉ (<span class="authorship-author-name">Chinopoulos Christos</span> <span class="authorAux-mtmt"> Bioenergetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34758725" target="_blank">Complex I activity in hypoxia: implications for oncometabolism</a></div> <div> <span class="journal-title">BIOCHEMICAL SOCIETY TRANSACTIONS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0300-5127">0300-5127</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1470-8752">1470-8752</a>)</span>: <span class="journal-volume">52</span> <span class="journal-issue">2</span> <span class="page"> pp 529-538 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1042/BST20230189" target="_blank" href="https://doi.org/10.1042/BST20230189"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001190691200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001190691200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85191614761" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85191614761"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38526218" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38526218&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191614761&doi=10.1042%2FBST20230189&partnerID=40&md5=a3047ea3d7af2fe302baa4c036e1d455" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191614761&doi=10.1042%2FBST20230189&partnerID=40&md5=a3047ea3d7af2fe302baa4c036e1d455"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34758725&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34758725</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.02. 12:52 Kajtár Virág Anna (SE_AOK_Biokemia_Admin5_KV, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :2 Export Date: 6 March 2025 CODEN: BCSTB Correspondence Address: Chinopoulos, C.; Department of Biochemistry, Hungary; email: chinopoulos.christos@semmelweis.hu</pre> </div></div>