https://m2.mtmt.hu/ hun 2026-09-22 14:31 JournalArticle 34755441 VALIDATED true Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Kirrberger Str. 100, Saar, Homburg, 66424, Germany Department of Ophthalmology, Semmelweis University, Mária Utca 39, Budapest, 1085, Hungary Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária Utca 41, Budapest, 1085, Hungary Argos Augenzentrum, Faktoreistraße 4, Saarbrücken, 66111, Germany Cited By :1 Export Date: 29 August 2024 Correspondence Address: Tóth, G.; Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Kirrberger Str. 100, Saar, Germany; email: gabortothgabor@gmail.com Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; allopurinol, 315-30-0, 17795-21-0; aminophenazone, 58-15-1, 8058-63-7; amoxicillin plus clavulanic acid, 74469-00-4, 79198-29-1; carbamazepine, 298-46-4, 8047-84-5; cefazolin, 25953-19-9, 27164-46-1; ceftazidime, 72558-82-8, 73547-61-2, 78439-06-2; ceftriaxone, 73384-59-5, 74578-69-1, 104376-79-6; cephalosporin, 11111-12-9; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0; clindamycin, 18323-44-9, 21462-39-5; cotrimoxazole, 8064-90-2; dexamethasone, 50-02-2; diclofenac, 15307-79-6, 15307-86-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3; fluorometholone, 426-13-1; ibuprofen, 15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6; lamotrigine, 84057-84-1; levofloxacin, 100986-85-4, 138199-71-0; mephenytoin, 50-12-4; moxifloxacin, 151096-09-2, 186826-86-8; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; ofloxacin, 82419-36-1; paracetamol, 103-90-2; prednisolone, 50-24-8; rifampicin, 13292-46-1; sulfamethoxypyridazine, 80-35-3; tetanus toxoid, 57425-69-1, 93384-51-1; tobramycin, 32986-56-4; vancomycin, 1404-90-6, 1404-93-9 0 false 2026-08-27T09:31:34.335+0000 2024-04-29T13:09:39.406+0000 2024-03-25T17:21:34.881+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-04-26T13:26:21.294+0000 2024-06-08T05:03:23.328+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tóth, Gábor Clinical Characteristics and Treatment of Ophthalmic Sequelae of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Eyecare Centre in Hungary true true /api/journal/10066996 REVIEWED true false 10066996 false 10066996 true 2193-8245 2193-6528 Journal FOREIGN 13 5 1343 1356 1343 14 2024 This study analysed the causative factors and clinical characteristics of acute and chronic ocular sequelae of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) treated at a large third-referral centre in a developed country (Hungary) over a 15-year period.This was a retrospective review of patients with acute and/or chronic SJS/TEN who were managed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University in Budapest, Hungary. For each subject, clinical data, including patient demographics, clinical history, causative agents of SJS/TEN, and conservative and surgical treatment details, were reviewed.Ninety-six eyes of 48 patients were included (28 female; 58.3%); the age at disease onset was 32.1 ± 22.4 years. The most common causative factors were medicines (n = 36; 75.0%). Among these drugs, 29.2% were nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 14), 20.8% were antibiotics (n = 10) and 14.6% were antiepileptic drugs (n = 7). In patients with chronic SJS/TEN, the most commonly found ocular sequelae were conjunctival hyperaemia in 45 (56.3%) eyes, symblepharon in 38 (47.5%) eyes, trichiasis/distichiasis in 37 (46.3%) eyes, corneal neovascularization in 31 (38.8%) eyes and corneal scarring in 29 (36.3%) eyes. In patients with chronic SJS/TEN, the most frequently used topical conservative treatment included antibiotics in 53 (66.3%) eyes, preservative-free artificial tears in 50 (62.5%) eyes and topical corticosteroids in 42 (52.5%) eyes of 40 patients. The most frequently performed ocular surgeries for managing chronic ocular sequelae in patients with SJS/TEN were epilation for trichiasis (n = 27; 33.8%), cataract surgery (n = 14; 17.5%), entropion surgery (n = 12; 15.0%), penetrating keratoplasty (PK) (n = 11; 13.8%) and amniotic membrane transplantation (n = 4; 5.0%).Our results suggest that NSAIDs, antibiotics and antiepileptic drugs are the most common causative factors for SJS/TEN in Hungary. Like in other countries, in Hungary, the ocular management of patients with acute and chronic SJS/TEN is heterogeneous, and most cases do not follow modern therapeutic guidelines. 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<span class="author-name" mtid="10036237"><a href="/gui2/?type=authors&mode=browse&sel=10036237" target="_blank">Lukács Andrea (<span class="authorship-author-name">Lukács Andrea</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stachon Tanja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schirra Frank </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025699"><a href="/gui2/?type=authors&mode=browse&sel=10025699" target="_blank">Sándor Gábor László (<span class="authorship-author-name">Sándor Gábor László</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009641"><a href="/gui2/?type=authors&mode=browse&sel=10009641" target="_blank">Nagy Zoltán Zsolt (<span class="authorship-author-name">Nagy Zoltán Zsolt</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000048"><a href="/gui2/?type=authors&mode=browse&sel=10000048" target="_blank">Szentmáry Nóra (<span class="authorship-author-name">Szentmáry Nóra</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34755441" target="_blank">Clinical Characteristics and Treatment of Ophthalmic Sequelae of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Eyecare Centre in Hungary</a></div> <div> <span class="journal-title">OPHTHALMOLOGY AND THERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2193-8245">2193-8245</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2193-6528">2193-6528</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">5</span> <span class="page"> pp 1343-1356 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s40123-024-00924-z" target="_blank" href="https://doi.org/10.1007/s40123-024-00924-z"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001190172300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001190172300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85188192932" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85188192932"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38507192" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38507192&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ophthalmology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 3 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34755441&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34755441</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Eötvös Scholarship </div> <div class="lastModified">Utolsó módosítás: 2024.04.29. 15:09 Horváth Viktória (SE_ETK_Admin5_HV, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Kirrberger Str. 100, Saar, Homburg, 66424, Germany Department of Ophthalmology, Semmelweis University, Mária Utca 39, Budapest, 1085, Hungary Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária Utca 41, Budap...</pre> </div></div>