The importance of maintaining proper magnesium intake and total body magnesium content
in preserving human health remains underappreciated among medical professionals and
laymen. This review aimed to show the importance of hypomagnesemia as a modifiable
risk factor for developing disease processes. We searched the PubMed database and
Google Scholar using the keywords ‘magnesium’, ‘diabetes’, ‘cardiovascular disease’,
‘respiratory disease’, ‘immune system’, ‘inflammation’, ‘autoimmune disease’, ‘neurology’,
‘psychiatry’, ‘cognitive function’, ‘cancer’, and ‘vascular calcification’. In multiple
contexts of the search terms, all reviews, animal experiments, and human observational
data indicated that magnesium deficiency can lead to or contribute to developing many
disease states. The conclusions of several in-depth reviews support our working hypothesis
that magnesium and its supplementation are often undervalued and underutilized. Although
much research has confirmed the importance of proper magnesium supply and tissue levels,
simple and inexpensive magnesium supplementation has not yet been sufficiently recognized
or promoted.
