https://m2.mtmt.hu/ hun 2026-04-30 06:45 PublicationOther 34747660 ADMIN_APPROVED true 0 false 2026-04-27T06:54:41.376+0000 2024-06-20T07:46:15.537+0000 2024-03-20T12:26:19.078+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2024-06-20T07:45:47.061+0000 2024-06-20T07:45:47.061+0000 2024-06-20T07:46:15.548+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true true 29 29 /api/publicationtype/29 PublicationType 15 true 29 PublicationOther true 10000261 Not classified true 29 29 /api/publicationtype/29 PublicationType 15 true 29 PublicationOther /api/subtype/10000261 Nem besorolt SubType 1585 true 10000261 true 1 /api/category/1 Category true 1 Virág Tóth, Csillag VITAMIN D DEFICIENCY ASSOCIATED WITH AGE-DEPENDENT VASCULAR DYSFUNCTION IN MICE 184 184 184 1 2023 true 357827 /api/conference/357827 true 11424 true 10001 /api/country/10001 Country true 1 /api/city/11424 City true 10000601 Conference true Introduction: Approximately 40% of the European population is vitamin D deficient, and the prevalence increases with age. In recent years, several studies have demonstrated that vitamin D deficiency leads to a deterioration of the cardiovascular system, including vascular function, but the precise pathomechanism of this decline, particularly in the elderly, is not fully understood. Aim: We aimed to investigate the vascular effects of vitamin D deficiency in young and aged mice and to identify the molecular and cellular mechanisms involved in the alteration of vascular reactivity. Methods: Segments of the thoracic aorta isolated from wild-type (WT) and vitamin D receptor gene deficient (VDR KO) young and aged (3 and 11 months) male mice were examined under isometric conditions using myograph. The vascular responses to phenylephrine were normalized to 124 mM K+ -induced contraction, and acetylcholineinduced endothelium-dependent relaxation was normalized to the pre-contraction induced by phenylephrine. In addition, we determined the expression levels of relaxation-associated M3 muscarinic receptor (Chrm3), endothelial nitric oxide NO synthase (Nos3), soluble guanylate cyclase (Gucy1a1 and Gucy1b1) and adventitial macrophage marker (F4/80) genes from myographically studied vessel segments. The presence of the macrophages was examined using immunhistochemistry. Results: While no differences were observed between contractions to phenylephrine, the relaxant effect of acetylcholine was significantly reduced in aortas of aged VDR KO mice compared to young WT, young KO and aged WT vessels (with 27.5; 25.7 and 25.7 %). No significant differences were observed in the expression of Chrm3, Nos3, Gucy1a1 and Gucy1b1 genes between experimental groups, but VDR deficient animals had higher levels of F4/80 mRNA regardless of age. There was a negative correlation between the expression of macrophage marker and the relaxation induced by acetylcholine (r=-0.2955, p<0.0106). Conclusion: Our results suggest that vitamin D deficiency impairs endotheliumdependent relaxation of blood vessels in older age. This is not due to impaired NO production or smooth muscle signalling, but is probably due to reactive oxygen free radicals produced by macrophages in the vascular adventitia, which react with the NO produced, thereby reducing its dilator capacity. These findings suggest that vitamin D deficiency induces a proinflammatory state with increased myeloid infiltration in the vascular wall, which is exacerbated with age. The resulting endothelial dysfunction may increase the risk of developing cardiovascular disease. Funding 2038314 /api/funding/2038314 false true Funding 2038315 /api/funding/2038315 false true Funding 2038316 /api/funding/2038316 false true Funding 2038317 /api/funding/2038317 false true Funding 2038318 /api/funding/2038318 false true true true 2024 true false true true false NONE 2026-04-27 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 false false false false 2024-06-17T09:27:36.487+0000 ELKH-SE Cerebrovaszkuláris és Neurokognitív Bet... (SE / AOK / I / TMI); Transzlációs Medicina Intézet (SE / AOK / I) 7 21 2 8 0 FAMÉ2023 2023-06-07 [Mátraháza, Magyarország] false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 115861594 /api/authorship/115861594 1 0.125 true false Author 10086970 /api/author/10086970 Tóth Csillag Virág true true Virág Tóth Csillag true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861595 /api/authorship/115861595 2 0.125 false false Author 10069772 /api/author/10069772 Kerkovits Nóra Melinda true true Melinda Kerkovits Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861596 /api/authorship/115861596 3 0.125 false false Kerék Margit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861597 /api/authorship/115861597 4 0.125 false false Author 10080442 /api/author/10080442 Babay Imre true true Babay Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861598 /api/authorship/115861598 5 0.125 false false Author 10075082 /api/author/10075082 Nagy Dorina true true Nagy Dorina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861599 /api/authorship/115861599 6 0.125 false false Author 10056835 /api/author/10056835 Pál Éva true 10056835 true Pál Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861600 /api/authorship/115861600 7 0.125 false false Author 10020915 /api/author/10020915 Kosztelnik Mónika true 10020915 true Kosztelnik Mónika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861601 /api/authorship/115861601 8 0.125 false true Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true /api/publication/34747660 <div class="PublicationOther Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10086970"><a href="/gui2/?type=authors&mode=browse&sel=10086970" target="_blank">Virág Tóth Csillag (<span class="authorship-author-name">Tóth Csillag Virág</span> <span class="authorAux-mtmt"> élettan, kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069772"><a href="/gui2/?type=authors&mode=browse&sel=10069772" target="_blank">Melinda Kerkovits Nóra (<span class="authorship-author-name">Kerkovits Nóra Melinda</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kerék Margit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080442"><a href="/gui2/?type=authors&mode=browse&sel=10080442" target="_blank">Babay Imre (<span class="authorship-author-name">Babay Imre</span> <span class="authorAux-mtmt"> élettan, kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075082"><a href="/gui2/?type=authors&mode=browse&sel=10075082" target="_blank">Nagy Dorina (<span class="authorship-author-name">Nagy Dorina</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056835"><a href="/gui2/?type=authors&mode=browse&sel=10056835" target="_blank">Pál Éva (<span class="authorship-author-name">Pál Éva</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020915"><a href="/gui2/?type=authors&mode=browse&sel=10020915" target="_blank">Kosztelnik Mónika (<span class="authorship-author-name">Kosztelnik Mónika</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34747660" target="_blank">VITAMIN D DEFICIENCY ASSOCIATED WITH AGE-DEPENDENT VASCULAR DYSFUNCTION IN MICE</a></div> <div class="description"> <div class="description0">FAMÉ2023 2023-06-07 [Mátraháza, Magyarország]</div> </div> <div class="country"> Megjelenés: <span class="pageLength">1 p.</span> <span class="publishedYear">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol </span> <span class="identifiers"> </span> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34747660</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás | <span class="type-subtype">Egyéb ( Nem besorolt ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-22-4-II-SE-17), (TKP2021-EGA-25), (PD-143327), (K-135683) Támogató: OTKA, (K-139230) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2024.06.20. 09:46 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> </div></div>