https://m2.mtmt.hu/ hun 2026-04-30 08:25 PublicationOther 34747645 ADMIN_APPROVED true 0 false 2026-04-23T03:22:25.283+0000 2024-06-20T07:45:29.321+0000 2024-03-20T12:21:30.458+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2024-06-20T07:45:22.956+0000 2024-06-20T07:45:22.956+0000 2024-06-20T07:45:29.328+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true true 29 29 /api/publicationtype/29 PublicationType 15 true 29 PublicationOther true 10000261 Not classified true 29 29 /api/publicationtype/29 PublicationType 15 true 29 PublicationOther /api/subtype/10000261 Nem besorolt SubType 1585 true 10000261 true 1 /api/category/1 Category true 1 Vén, Krisztina THE ADVENTITIAL LAYER PLAYS A CRUCIAL ROLE IN THE SIGNAL TRANSDUCTION OF VASOCONSTRICTION INDUCED BY 18:2 LYSOPHOSPHATIDIC ACID 179 179 179 1 2023 true 357827 /api/conference/357827 true 11424 true 10001 /api/country/10001 Country true 1 /api/city/11424 City true 10000601 Conference true Lysophosphatidic acid (LPA) is a bioactive lipid mediator, which exerts its effects via its six specific GPCRs mediating important physiological and pathophysiological responses, like platelet activation or cell-migration. During vascular injury or rupture of an atherosclerotic plaque, the consequential platelet activation leads to the release of mainly polyunsaturated LPAs, especially 18:2 LPA. In hypertension and acute myocardial infarction, the level of these polyunsaturated LPAs is also elevated. Based on the previous results of our research group, LPA1 receptor activation by the 18:2 LPA evokes cyclooxygenase 1 activation with consequential thromboxane A2 (TXA2) release, and vasoconstriction. In this study we further analyzed the signaling mechanisms underlying the constrictor effect of 18:2 LPA. We did experiments in aortas isolated from Bl6 mice. Our main method was the measurement of the vascular tone with myography. The endothelium, and in some cases the adventitia as well, was mechanically removed and the 18:2 LPA was administered on the resting tone. TXA2 release of the vessels was measured by ELISA. Primary vascular cells were isolated from different layers of the aorta and their intracellular Ca2+ signal upon LPA administration was determined. qPCR was used to measure the expression of the LPA1 receptor in the lamina media and adventitia. According to our results, removal of the adventitia significantly decreases the elicited vasoconstriction, and results in a complete loss of thromboxane release. In agreement with this, LPA1 receptor is predominantly expressed in the adventitial layer, as removal of the adventitia resulted in diminished expression of Lpar1. Staining of the LPA1 receptor was only present in the adventitial layer, but not in the lamina media. Primary isolated vascular smooth muscle cells exhibited negligible Ca2+ signal upon administration of 18:2 LPA, however a subpopulation of adventitial cells showed marked intracellular Ca2+ increase when stimulated by 18:2 LPA. In conclusion, LPA 18:2 has strong vasoconstrictor activity, due to its ability to increase LPAR1–Gi–COX mediated thromboxane release from the adventitia, highlighting the significance of this layer in the regulation of vasomotion. true true 2024 true false true true false NONE 2026-04-23 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 false false false false 2024-06-18T11:21:35.520+0000 Transzlációs Medicina Intézet (SE / AOK / I) 6 26 1 6 0 FAMÉ2023 2023-06-07 [Mátraháza, Magyarország] false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 115861527 /api/authorship/115861527 1 0.16666667 true false Author 10068015 /api/author/10068015 Vén Krisztina Eszter true true Vén Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861528 /api/authorship/115861528 2 0.16666667 false false Author 10068063 /api/author/10068063 Besztercei Balázs true true Besztercei Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861529 /api/authorship/115861529 3 0.16666667 false false Author 10020915 /api/author/10020915 Kosztelnik Mónika true 10020915 true Kosztelnik Mónika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861530 /api/authorship/115861530 4 0.16666667 false false Author 10046134 /api/author/10046134 Tigyi Gabor true 10046134 true Tigyi Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861531 /api/authorship/115861531 5 0.16666667 false false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115861532 /api/authorship/115861532 6 0.16666667 false true Author 10025626 /api/author/10025626 Ruisanchez Éva true 10025626 true Ruisanchez Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true /api/publication/34747645 <div class="PublicationOther Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10068015"><a href="/gui2/?type=authors&mode=browse&sel=10068015" target="_blank">Vén Krisztina (<span class="authorship-author-name">Vén Krisztina Eszter</span> <span class="authorAux-mtmt"> Élettan, neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068063"><a href="/gui2/?type=authors&mode=browse&sel=10068063" target="_blank">Besztercei Balázs (<span class="authorship-author-name">Besztercei Balázs</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020915"><a href="/gui2/?type=authors&mode=browse&sel=10020915" target="_blank">Kosztelnik Mónika (<span class="authorship-author-name">Kosztelnik Mónika</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046134"><a href="/gui2/?type=authors&mode=browse&sel=10046134" target="_blank">Tigyi Gábor (<span class="authorship-author-name">Tigyi Gabor</span> <span class="authorAux-mtmt"> Lipid biokemia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025626"><a href="/gui2/?type=authors&mode=browse&sel=10025626" target="_blank">Ruisanchez Éva (<span class="authorship-author-name">Ruisanchez Éva</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34747645" target="_blank">THE ADVENTITIAL LAYER PLAYS A CRUCIAL ROLE IN THE SIGNAL TRANSDUCTION OF VASOCONSTRICTION INDUCED BY 18:2 LYSOPHOSPHATIDIC ACID</a></div> <div class="description"> <div class="description0">FAMÉ2023 2023-06-07 [Mátraháza, Magyarország]</div> </div> <div class="country"> Megjelenés: <span class="pageLength">1 p.</span> <span class="publishedYear">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol </span> <span class="identifiers"> </span> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34747645</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás | <span class="type-subtype">Egyéb ( Nem besorolt ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.06.20. 09:45 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> </div></div>