Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation

Lőrincz, Csanád Endre; Börzsei, Denise [Börzsei, Denise (Élettan), szerző] Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI); Hoffmann, Alexandra [Nagyné Hoffmann, Alexandra (Kutató biológus), szerző] Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI); Varga, Csaba [Varga, Csaba (Endokrinológia, g...), szerző] Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI); Szabó, Renáta ✉ [Szabó, Renáta (kutató biológus), szerző] Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI)

Angol nyelvű Összefoglaló cikk (Folyóiratcikk) Tudományos
Megjelent: BIOMEDICINES 2227-9059 12 (3) p. 560 , 15 p. 2024
  • SJR Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous): Q1
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  • (143241) Támogató: OTKA
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2025-02-13 17:28