https://m2.mtmt.hu/ hun 2026-10-24 07:59 JournalArticle 34729969 ADMIN_APPROVED true Department of Radiation Oncology, Antoine Lacassagne Cancer Center, University Côte d'Azur, 33 avenue Valombrose, Nice Cedex 2, Nice, 06189, France Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain Department of Statistics, Antoine Lacassagne Cancer Center – University of Côte d'Azur, Nice, France Department of Radiation Oncology, Hospital Universitario Marques de Valdecilla, Santander, Spain Department of Radiation Oncology, Instituto Valenciano de Oncologia, Valencia, Spain Department of Radiation Oncology, Hospital Clínico San Carlos, Madrid, Spain National Institute of Oncology and National Tumor Biology Laboratory, Budapest, Hungary Department of Oncology, Semmelweis University, Budapest, Hungary Department of Radiation Oncology, Erlangen University Hospital, Erlangen, Germany Department of Radiation Oncology, Catalan Institute of Oncology, Barcelona, Spain Cited By :1 Export Date: 24 July 2024 CODEN: RAOND Correspondence Address: Hannoun-Levi, J.-M.; Radiation Oncology Department, 33 Avenue Valombrose, France; email: jean-michel.hannoun-levi@nice.unicancer.fr Chemicals/CAS: trastuzumab, 180288-69-1, 1446410-98-5 0 false 2026-05-28T12:58:34.190+0000 2024-11-17T11:26:00.762+0000 2024-03-11T12:53:26.608+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2025-09-01T10:21:21.443+0000 2024-11-17T11:26:00.997+0000 true 10080105 Kériné Tornyi Katalin /api/admin/10080105 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080105 /api/admin/10080105 Kériné Tornyi Katalin true true 2024-10-17T16:16:12.275+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hannoun-Levi, Jean-Michel Very accelerated partial breast irradiation in 1 or 2 days Late toxicity and early oncological outcome of the GEC-ESTRO VAPBI cohort true true /api/journal/3865 REVIEWED true false 3865 false 3865 true 0167-8140 1879-0887 Journal FOREIGN 194 110217 110217 7 2024 To analyze late toxicity after very accelerated partial breast irradiation (VAPBI) for low-risk breast cancer.Methods: In this retrospective, observational, international multicenter study (HDH F20220713143949), patients with low-risk breast cancer underwent lumpectomy + vAPBI (high-dose rate multicatheter interstitial brachytherapy-MIBT). VAPBI was performed with 4(4x6.2Gy/2d), 3(3x7.45Gy/2d) or 1 fraction (1x16Gy or 1x18Gy/1d). Primary endpoint was late toxicity. Secondary endpoints were cumulative incidence of breast cancer local relapse (LR) and distant metastatic relapse (DMR) and specific (SS) and overall (OS) survivals. Prognostic factors for late toxicity were analyzed.From 01/2012 to 06/2022, 516 pts with early breast cancer were enrolled. Median follow-up was 44 months [95%CI 39-46]. Median age was 71 years [40-100]. Median tumor size was 12mm [1-35]. VAPBI delivered 1, 3 and 4 fractions for 205pts (39.7%), 167pts (32.4%) and 144pts (28%) respectively. 221 late toxicity events were observed in 168pts (32.6%) (Fibrosis, dyschromia, pain and telangiectasia). Grade 2 and 3 late toxicities were observed in 7.2 and 0.6% respectively (no G4) with no difference between 1 and ≥2 treatment days. CTV>50cc (p=0.007) and V150>40% (p=0.027) were prognostic factors for G≥2 late toxicity. Four-year cumulative incidence rates of LR and DMR were 2% [95%CI 0-3] and 1% [95%CI 0-2] respectively.VAPBI based on 1 or ≥2 days of MIBT represents an attractive de-escalation of irradiation approach for low-risk breast cancer. Late toxicity profile appears acceptable while early oncological outcome shows encouraging local control. Longer follow-up is warranted in order to confirm these preliminary results. true 2024 true true true false true false NONE 2026-05-28 false 12 0 12 4 3 12 12 12 11 12 12 4 4 4 8 0 12 4 12 4 0 8 8 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 4 1 4 1 2025 0 3 1 3 1 2026 0 5 2 5 2 D1 false false false false 2024-03-19T10:26:22.628+0000 Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 2 7 2 11 0 true 10080105 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 115662464 /api/authorship/115662464 1 0.091 true false true Hannoun-Levi Jean-Michel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662465 /api/authorship/115662465 2 0.09090909 false false false Gimeno Morales Marta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662466 /api/authorship/115662466 3 0.09090909 false false false Gal Jocelyn true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662467 /api/authorship/115662467 4 0.09090909 false false false Anchuelo Javier true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662468 /api/authorship/115662468 5 0.09090909 false false false Guinot Jose-Luis true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662469 /api/authorship/115662469 6 0.09090909 false false false Gastanaga Miren true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662470 /api/authorship/115662470 7 0.091 false false false Author 10057309 /api/author/10057309 Mészáros Norbert true 10057309 true Meszaros Norbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662471 /api/authorship/115662471 8 0.091 false false Author 10013383 /api/author/10013383 Polgár Csaba true 10013383 true Polgar Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662472 /api/authorship/115662472 9 0.09090909 false false false Strnad Vratislav true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662473 /api/authorship/115662473 10 0.09090909 false false false Schiappa Renaud true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115662474 /api/authorship/115662474 11 0.09090909 false true false Gutierrez Cristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25845324 /api/publicationidentifier/25845324 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.radonc.2024.110217 https://doi.org/10.1016/j.radonc.2024.110217 false true PublicationIdentifier 26235212 /api/publicationidentifier/26235212 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001218813000001 https://www.webofscience.com/wos/woscc/full-record/001218813000001 true true PublicationIdentifier 25889500 /api/publicationidentifier/25889500 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85187511354 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85187511354 true true PublicationIdentifier 25845323 /api/publicationidentifier/25845323 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38460552 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38460552&dopt=Abstract false true Keyword 6490 /api/keyword/6490 true 6490 true Keyword 19760 /api/keyword/19760 true 19760 true Keyword 20010 /api/keyword/20010 true 20010 true Keyword 1010011 /api/keyword/1010011 true 1010011 true Keyword 1528853 /api/keyword/1528853 true true Keyword 1605449 /api/keyword/1605449 true true SjrRating 11497490 /api/sjrrating/11497490 21 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2741 /api/classificationexternal/2741 true 2741 true D1 DIRECT true true /api/publication/34729969 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hannoun-Levi Jean-Michel ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gimeno Morales Marta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gal Jocelyn </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anchuelo Javier </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Guinot Jose-Luis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gastanaga Miren </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057309"><a href="/gui2/?type=authors&mode=browse&sel=10057309" target="_blank">Meszaros Norbert (<span class="authorship-author-name">Mészáros Norbert</span> <span class="authorAux-mtmt"> sugárterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgar Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Strnad Vratislav </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schiappa Renaud </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gutierrez Cristina </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34729969" target="_blank">Very accelerated partial breast irradiation in 1 or 2 days : Late toxicity and early oncological outcome of the GEC-ESTRO VAPBI cohort.</a></div> <div> <span class="journal-title">RADIOTHERAPY AND ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-8140">0167-8140</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-0887">1879-0887</a>)</span>: <span class="journal-volume">194</span> <span class="page"> Paper 110217. 7 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.radonc.2024.110217" target="_blank" href="https://doi.org/10.1016/j.radonc.2024.110217"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001218813000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001218813000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85187511354" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85187511354"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38460552" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38460552&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hematology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 4 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;12 | DOI jelölt:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34729969&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34729969</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.17. 12:26 Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:16 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Radiation Oncology, Antoine Lacassagne Cancer Center, University Côte d'Azur, 33 avenue Valombrose, Nice Cedex 2, Nice, 06189, France Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain Department of Statistics, Antoine Lacassagne Cancer Center – University of Côte d'Azur, Nice, France ...</pre> </div></div>