https://m2.mtmt.hu/ hun 2026-09-21 13:02 JournalArticle 34726620 VALIDATED true Department of Medical Oncology, Hospital Universitario12de Octubre, Lung Cancer Unit CNIO-H120, Complutense University and Ciberonc, Madrid, Spain Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Department of Medicine, Section of Hematology/Oncology, Thoracic Oncology Unit, University of Chicago, Chicago, IL, United States Cancer and Hematology Centers of Western Michigan, Grand Rapids, MI, United States Asklepios Lung Clinic, Member of the German Center for Lung Research (DZL), Gauting, Munich, Germany Okayama University Hospital, Okayama, Japan Petrov Research Institute ofOncology, St. Petersburg, Russian Federation Odessa Regional Oncological Dispensary, Odessa, Ukraine Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria Istanbul University-Cerrahpaşa, Cerrahpaşa School ofMedicine, Istanbul, Turkey Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine, Changwon, South Korea Omsk Regional Cancer Center, Omsk, Russian Federation Clinic of MedicalOncology, UMHAT StMarina, Varna, Bulgaria Dnipropetrovsk Medical Academy, Dnipro, Ukraine Thomayer Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic Semmelweis University, Budapest, Hungary AstraZeneca, Waltham, MA, United States Astra- Zeneca, Gaithersburg, MD, United States AstraZeneca, Cambridge, United Kingdom David Geffen School of Medicine at UCLA, Los Angeles, CA, United States Cited By :3 Export Date: 15 April 2024 CODEN: CCREF Correspondence Address: Paz-Ares, L.; Hospital Universitario 12 de Octubre, Av de Cordoba s/n, Spain; email: lpazaresr@seom.org Correspondence Address: Shrestha, Y.1 Medimmune Way, AstraZeneca, United States; email: yashaswi.shrestha@astrazeneca.com Chemicals/CAS: carboplatin, 41575-94-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; durvalumab, 1428935-60-7; etoposide, 33419-42-0, 433304-61-1; ipilimumab, 477202-00-9; nivolumab, 946414-94-4; pembrolizumab, 1374853-91-4; platinum, 7440-06-4; ticilimumab, 745013-59-6; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; B7-H1 Antigen; durvalumab; Etoposide; Platinum; tremelimumab Funding details: AstraZeneca España Funding text 1: The study was funded by AstraZeneca. 0 false 2026-07-19T10:25:55.007+0000 2024-03-08T07:38:43.290+0000 2024-03-08T07:24:30.329+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2025-07-21T12:41:00.427+0000 2024-03-08T07:38:43.306+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Paz-Ares, Luis Durvalumab ± Tremelimumab plus Platinum-Etoposide in Extensive-Stage Small Cell Lung Cancer (CASPIAN): Outcomes by PD-L1 Expression and Tissue Tumor Mutational Burden true true /api/journal/1405637 REVIEWED true false 1405637 false 1405637 true 1078-0432 1557-3265 Journal FOREIGN 30 4 824 835 824 12 2024 Purpose: In the CASPIAN trial, first-line durvalumab plus platinum-etoposide (EP) significantly improved overall survival (OS) versus EP alone in extensive-stage small cell lung cancer (ES-SCLC). We report exploratory analyses of CASPIAN outcomes by programmed cell death ligand-1 (PD-L1) expression and tissue tumor mutational burden (tTMB). Experimental design: Patients were randomized (1:1:1) to durvalumab (1,500 mg) plus EP, durvalumab plus tremelimumab (75 mg) plus EP, or EP alone. Treatment effects in PD-L1 and tTMB subgroups were estimated using an unstratified Cox proportional hazards model. Results: The PD-L1 and tTMB biomarker-evaluable populations (BEP) comprised 54.4% (438/805) and 35.2% (283/805) of the intention-to-treat population, respectively. PD-L1 prevalence was low: 5.7%, 25.8%, and 28.3% had PD-L1 expression on >= 1% tumor cells (TC), >= 1% immune cells (IC), and >= 1% TCs or ICs, respectively. OS benefit with durvalumab plus EP versus EP was similar across PD-L1 subgroups, with HRs all falling within the 95% confidence interval (CI) for the PD-L1 BEP (0.47-0.79). OS benefit with durvalumab plus tremelimumab plus EP versus EP was greater in PD-L1 >= 1% versus <1% subgroups, although CIs overlapped. There was no evidence of an interaction between tTMB and treatment effect on OS (durvalumab plus EP vs. EP, P = 0.916; durvalumab plus tremelimumab plus EP vs. EP, P = 0.672). Conclusions: OS benefit with first-line durvalumab plus EP in patients with ES-SCLC was observed regardless of PD-L1 or tTMB status. PD-L1 expression may prove to be a useful biomarker for combined treatment with PD-(L)1 and CTLA-4 inhibition, although this requires confirmation with an independent dataset. See related commentary by Rolfo and Russo, p. 652. true true 2024 true true true false true false GOLD 2026-07-19 true https://doi.org/10.1158/1078-0432.CCR-23-1689 57 0 57 49 1 57 57 54 56 57 57 49 49 49 8 0 57 49 57 49 0 4 4 Folyóiratcikk Journal Article 24 57 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 17 15 17 15 2025 0 31 26 31 26 2026 0 9 8 9 8 D1 false false 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/api/reference/50818532 45 false true Reference 50818533 /api/reference/50818533 46 false true Reference 50818534 /api/reference/50818534 47 false true /api/publication/34726620 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Paz-Ares Luis ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garassino Marina Chiara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen Yuanbin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reinmuth Niels </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hotta Katsuyuki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Poltoratskiy Artem </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Trukhin Dmytro </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hochmair Maximilian J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oezgueroglu Mustafa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ji Jun Ho </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Statsenko Galina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Conev Nikolay </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bondarenko Igor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Havel Libor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004124"><a href="/gui2/?type=authors&mode=browse&sel=10004124" target="_blank">Losonczy Gyoergy (<span class="authorship-author-name">Losonczy György</span> <span class="authorAux-mtmt"> Pulmonológia, klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Xie Mingchao </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lai Zhongwu </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Godin-Heymann Nadia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mann Helen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jiang Haiyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shrestha Yashaswi ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goldman Jonathan W. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34726620" target="_blank">Durvalumab ± Tremelimumab plus Platinum-Etoposide in Extensive-Stage Small Cell Lung Cancer (CASPIAN): Outcomes by PD-L1 Expression and Tissue Tumor Mutational Burden</a></div> <div> <span class="journal-title">CLINICAL CANCER RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1078-0432">1078-0432</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-3265">1557-3265</a>)</span>: <span class="journal-volume">30</span> <span class="journal-issue">4</span> <span class="page"> pp 824-835 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1158/1078-0432.CCR-23-1689" target="_blank" href="https://doi.org/10.1158/1078-0432.CCR-23-1689"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001163758000014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001163758000014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85183068143" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85183068143"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37801329" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37801329&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 57</span> | Független: 49 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 54 | Scopus jelölt:&nbsp;56 | WoS/Scopus jelölt:&nbsp;57 | DOI jelölt:&nbsp;57 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34726620&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34726620</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2024.03.08. 08:38 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Medical Oncology, Hospital Universitario12de Octubre, Lung Cancer Unit CNIO-H120, Complutense University and Ciberonc, Madrid, Spain Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Department of Medicine, Section of Hematology/Oncology, Thoracic Oncology Unit, University of Chicago, Chicago, IL, United States ...</pre> 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