https://m2.mtmt.hu/ eng 2026-05-30 10:46 JournalArticle 34725864 VALIDATED true * Megosztott szerzőség 0 false 2026-05-23T15:08:34.260+0000 2024-09-13T13:16:17.776+0000 2024-03-07T13:23:20.572+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-02-21T10:21:43.176+0000 2024-09-13T13:16:17.993+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:22.709+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Paniagua-Herranz, Lucía Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2 true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 4 2222 2222 14 2024 The identification of surfaceome proteins is a main goal in cancer research to design antibody-based therapeutic strategies. T cell engagers based on KLK2, a kallikrein specifically expressed in prostate cancer (PRAD), are currently in early clinical development. Using genomic information from different sources, we evaluated the immune microenvironment and genomic profile of prostate tumors with high expression of KLK2. KLK2 was specifically expressed in PRAD but it was not significant associated with Gleason score. Additionally, KLK2 expression did not associate with the presence of any immune cell population and T cell activating markers. A mild correlation between the high expression of KLK2 and the deletion of TMPRSS2 was identified. KLK2 expression associated with high levels of surface proteins linked with a detrimental response to immune checkpoint inhibitors (ICIs) including CHRNA2, FAM174B, OR51E2, TSPAN1, PTPRN2, and the non-surface protein TRPM4. However, no association of these genes with an outcome in PRAD was observed. Finally, the expression of these genes in PRAD did not associate with an outcome in PRAD and any immune populations. We describe the immunologic microenvironment on PRAD tumors with a high expression of KLK2, including a gene signature linked with an inert immune microenvironment, that predicts the response to ICIs in other tumor types. Strategies targeting KLK2 with T cell engagers or antibody-drug conjugates will define whether T cell mobilization or antigen release and stimulation of immune cell death are sufficient effects to induce clinical activity. true INTERNATIONAL 2024 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms25042222 10 0 10 10 0 10 10 9 7 9 9 9 9 10 0 0 10 10 10 10 0 2 2 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 5 5 5 5 2026 0 5 5 5 5 D1 false false false false 2024-03-07T07:08:37.464+0000 Biofizikai Intézet (PTE / ÁOK); Bioinformatika Tanszék (SE / AOK / I); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 1 26 3 17 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 115626440 /api/authorship/115626440 1 0.05882353 true false false Paniagua-Herranz Lucía true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626441 /api/authorship/115626441 2 0.059 true false false Moreno Irene true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626442 /api/authorship/115626442 3 0.05882353 false false false Nieto-Jiménez Cristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626443 /api/authorship/115626443 4 0.05882353 false false false Garcia-Lorenzo Esther true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626444 /api/authorship/115626444 5 0.05882353 false false false Díaz-Tejeiro Cristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626445 /api/authorship/115626445 6 0.05882353 false false false Sanvicente Adrián true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626446 /api/authorship/115626446 7 0.05882353 false false false Doger Bernard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626447 /api/authorship/115626447 8 0.05882353 false false false Pedregal Manuel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626448 /api/authorship/115626448 9 0.05882353 false false false Ramón Jorge true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626449 /api/authorship/115626449 10 0.05882353 false false false Bartolomé Jorge true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626450 /api/authorship/115626450 11 0.05882353 false false false Manzano Arancha true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626451 /api/authorship/115626451 12 0.059 false false false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Gyorffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626452 /api/authorship/115626452 13 0.05882353 false false false Gutierrez-Uzquiza Álvaro true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626453 /api/authorship/115626453 14 0.05882353 false false false Pérez Segura Pedro true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626454 /api/authorship/115626454 15 0.05882353 false false false Calvo Emiliano true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626455 /api/authorship/115626455 16 0.05882353 false false false Moreno Víctor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115626456 /api/authorship/115626456 17 0.059 false true true Ocana Alberto true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25835977 /api/publicationidentifier/25835977 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25042222 https://doi.org/10.3390/ijms25042222 false true PublicationIdentifier 25900640 /api/publicationidentifier/25900640 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001168249300001 https://www.webofscience.com/wos/woscc/full-record/001168249300001 false true PublicationIdentifier 25835983 /api/publicationidentifier/25835983 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85185942812 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185942812 false true PublicationIdentifier 25835976 /api/publicationidentifier/25835976 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38396898 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38396898&dopt=Abstract false true Keyword 1030129 /api/keyword/1030129 true 1030129 true Keyword 1899040 /api/keyword/1899040 true true Keyword 2080429 /api/keyword/2080429 true true Keyword 3358115 /api/keyword/3358115 true true Keyword 3358116 /api/keyword/3358116 true true SjrRating 11489344 /api/sjrrating/11489344 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 true 1605 true D1 DIRECT true true /api/publication/34725864 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Paniagua-Herranz Lucía </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moreno Irene<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nieto-Jiménez Cristina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Lorenzo Esther </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Díaz-Tejeiro Cristina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sanvicente Adrián </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doger Bernard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pedregal Manuel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ramón Jorge </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bartolomé Jorge </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Manzano Arancha </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Gyorffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Biophysics; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gutierrez-Uzquiza Álvaro </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pérez Segura Pedro </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Calvo Emiliano </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moreno Víctor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ocana Alberto ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34725864" target="_blank">Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">4</span> <span class="page"> Paper 2222. 14 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25042222" target="_blank" href="https://doi.org/10.3390/ijms25042222"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001168249300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001168249300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85185942812" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185942812"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38396898" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38396898&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 10 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34725864&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34725864</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2024.09.13. 15:16 Anna Berhidi (SE_KK_Admin5_BA, admin) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség</pre> </div></div>