https://m2.mtmt.hu/ hun 2026-07-27 11:03 JournalArticle 34693250 VALIDATED true 0 false 2026-05-23T14:45:48.433+0000 2025-10-27T07:28:01.552+0000 2024-02-29T07:34:23.214+0000 true 10094277 Nagy Nikolett /api/author/10094277 Author true 2026-03-11T09:16:02.400+0000 2024-02-29T07:47:31.175+0000 true 10036499 Paszternák Anikó /api/admin/10036499 Admin true 10036499 2024-06-10T20:10:57.006+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10099440 /api/admin/10099440 Csernyik Rita true true 2025-10-21T01:37:28.906+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy, Nikolett Antiphospholipid Antibodies Are Major Risk Factors for Non-Thrombotic Cardiac Complications in Systemic Lupus Erythematosus true true /api/journal/10056704 REVIEWED true false 10056704 false 10056704 true 2227-9059 Journal FOREIGN 12 3 530 530 15 2024 In systemic lupus erythematosus (SLE), cardiovascular complications are among the leading causes of death. Cardiovascular risk in SLE is even higher in the presence of antiphospholipid antibodies or secondary antiphospholipid syndrome (APS). The aim of this retrospective, single-center study was to investigate the occurrence of antiphospholipid antibodies and non-thrombotic cardiac manifestations in 369 SLE patients. We also assessed the clinical and laboratory characteristics of the patients to reveal the risk factors for cardiac manifestations. Patients were divided into two groups based on the presence of antiphospholipid antibodies (APA); 258 (69.9%) patients were APA positive, and 111 (30.1%) patients were APA negative. Mitral and tricuspid insufficiency, aortic stenosis and pulmonary arterial hypertension were more common in APA-positive patients. Anticardiolipin IgG showed the strongest correlation with any non-thrombotic cardiac manifestations. Based on our results, the adjusted global antiphospholipid syndrome score (aGAPSS) above 8.5 is predictive of valvulopathies and ischemic heart disease, while aGAPSS above 9.5 is predictive of cardiomyopathies. The presence of antiphospholipid antibodies may affect the development of cardiac manifestations in SLE. Periodic cardiological and echocardiographic screening of patients without cardiac complaints, as well as regular monitoring of antiphospholipid antibodies, have great importance during the treatment of SLE patients. 2024 true true true false false GOLD 2026-05-23 false https://www.mdpi.com/journal/biomedicines 10 0 10 9 1 10 10 8 8 10 10 9 9 9 1 0 10 9 10 9 0 3 3 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 8 7 8 7 2026 0 2 2 2 2 Q1 false 10030122,10100639 false false false 2024-02-28T07:47:30.907+0000 C épület (DE / KK / BelgyKL); Klinikai Immunológiai Tanszék (DE / ÁOK / BelgyI) 4 14 2 8 0 true 10099440 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 115308591 /api/authorship/115308591 1 0.125 true false false Author 10094277 /api/author/10094277 Nagy Nikolett true true Nagy Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308592 /api/authorship/115308592 2 0.125 false false false Bói Bernadett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308593 /api/authorship/115308593 3 0.125 false false false Author 10044345 /api/author/10044345 Papp Gábor true 10044345 true Papp Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308594 /api/authorship/115308594 4 0.125 false false false Fiák Edit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308595 /api/authorship/115308595 5 0.125 false false false Gáspár-Kiss Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308596 /api/authorship/115308596 6 0.125 false false false Author 10100639 /api/author/10100639 Perge Bianka true true Perge Bianka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308597 /api/authorship/115308597 7 0.125 false false false Farmasi Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 115308598 /api/authorship/115308598 8 0.125 false true true Author 10030122 /api/author/10030122 Tarr Tünde true 10030122 true Tarr Tünde true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25765062 /api/publicationidentifier/25765062 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.3390/biomedicines12030530 https://doi.org/10.3390/biomedicines12030530 false true PublicationIdentifier 26165055 /api/publicationidentifier/26165055 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001191781000001 https://www.webofscience.com/wos/woscc/full-record/001191781000001 false true PublicationIdentifier 26165054 /api/publicationidentifier/26165054 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85188726976 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85188726976 false true PublicationIdentifier 25765063 /api/publicationidentifier/25765063 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.mdpi.com/2227-9059/12/3/530 https://www.mdpi.com/2227-9059/12/3/530 false true Keyword 16724 /api/keyword/16724 true 16724 true Keyword 17351 /api/keyword/17351 true 17351 true Keyword 1648859 /api/keyword/1648859 true true Keyword 3356436 /api/keyword/3356436 true true SjrRating 11443691 /api/sjrrating/11443691 69 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true Q1 DIRECT true true /api/publication/34693250 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10094277"><a href="/gui2/?type=authors&mode=browse&sel=10094277" target="_blank">Nagy Nikolett (<span class="authorship-author-name">Nagy Nikolett</span> <span class="authorAux-mtmt"> belgyógyászat, immunológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Klinikai Központ">KK</span>/<span title="Belgyógyászati Klinika">BelgyKL</span>/C épület; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bói Bernadett </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044345"><a href="/gui2/?type=authors&mode=browse&sel=10044345" target="_blank">Papp Gábor (<span class="authorship-author-name">Papp Gábor</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Klinikai Központ">KK</span>/<span title="Belgyógyászati Klinika">BelgyKL</span>/C épület; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fiák Edit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gáspár-Kiss Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100639"><a href="/gui2/?type=authors&mode=browse&sel=10100639" target="_blank">Perge Bianka (<span class="authorship-author-name">Perge Bianka</span> <span class="authorAux-mtmt"> belgyógyászat, immunológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Farmasi Nikolett </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030122"><a href="/gui2/?type=authors&mode=browse&sel=10030122" target="_blank">Tarr Tünde ✉ (<span class="authorship-author-name">Tarr Tünde</span> <span class="authorAux-mtmt"> klinikai orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Klinikai Központ">KK</span>/<span title="Belgyógyászati Klinika">BelgyKL</span>/C épület; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Klinikai Immunológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34693250" target="_blank">Antiphospholipid Antibodies Are Major Risk Factors for Non-Thrombotic Cardiac Complications in Systemic Lupus Erythematosus</a></div> <div> <span class="journal-title">BIOMEDICINES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2227-9059">2227-9059</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">3</span> <span class="page"> Paper 530. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="10.3390/biomedicines12030530" target="_blank" href="https://doi.org/10.3390/biomedicines12030530"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001191781000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001191781000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85188726976" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85188726976"> Scopus </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.mdpi.com/2227-9059/12/3/530" target="_blank" href="https://www.mdpi.com/2227-9059/12/3/530"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 9 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34693250&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34693250</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">DEENK-PA</span> </div> <div class="lastModified">Utolsó módosítás: 2025.10.27. 08:28 Csernyik Rita (MTMT központi admin) </div> <div class="lockedBy">Központi kezelésű 2025.10.21. 03:37 Csernyik Rita (MTMT központi admin) </div> </div></div>