https://m2.mtmt.hu/ eng 2026-09-23 08:39 JournalArticle 34684374 VALIDATED true Department of Public Health, Semmelweis University, Budapest, Hungary Departments of Hematology and Stem Cell Transplantation, South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Saint Ladislaus Campus, Budapest, Hungary Export Date: 25 July 2025; Cited By: 33; Correspondence Address: V. Fazekas-Pongor; Department of Public Health, Semmelweis University, Budapest, Hungary; email: pongor.vince@semmelweis.hu; CODEN: POREF 0 false 2026-09-21T16:19:04.063+0000 2026-06-05T13:12:47.989+0000 2024-02-26T07:14:08.229+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin Tamás Fi (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) true 2026-08-10T07:47:44.965+0000 2025-06-02T06:40:32.628+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Tamásné Gere (SE_KK_Admin5_GT, admin) true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Fekete, Mónika true true /api/journal/1035680 REVIEWED PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 30 1611623 1611623 14 2024 Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel the intricate relationship between the aging process and pathogenesis of age-related diseases. This paper explores the pivotal role played by geroscience in reshaping our understanding of pathology, with a particular focus on age-related diseases. These diseases, spanning cardiovascular and cerebrovascular disorders, malignancies, and neurodegenerative conditions, significantly contribute to the morbidity and mortality of older individuals. We delve into the fundamental cellular and molecular mechanisms underpinning aging, including mitochondrial dysfunction and cellular senescence, and elucidate their profound implications for the pathogenesis of various age-related diseases. Emphasis is placed on the importance of assessing key biomarkers of aging and biological age within the realm of pathology. We also scrutinize the interplay between cellular senescence and cancer biology as a central area of focus, underscoring its paramount significance in contemporary pathological research. Moreover, we shed light on the integration of anti-aging interventions that target fundamental aging processes, such as senolytics, mitochondria-targeted treatments, and interventions that influence epigenetic regulation within the domain of pathology research. In conclusion, the integration of geroscience concepts into pathological research heralds a transformative paradigm shift in our understanding of disease pathogenesis and promises breakthroughs in disease prevention and treatment. Funding 2037618 /api/funding/2037618 (TKP2021-NKTA-47) false true Funding 2037619 /api/funding/2037619 Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Funder: NRDIO false true Funding 2037620 /api/funding/2037620 (101004093/EUniWell/EAC-A02- 2019/EAC-A02-2019-1) false true true true 2024 true true true false true false GOLD 2026-09-21 true https://doi.org/10.3389/pore.2024.1611623 87 0 87 30 62 85 62 53 54 57 57 25 25 30 57 0 87 30 87 30 0 43 43 Folyóiratcikk Journal Article 24 61 Könyvrészlet Chapter in Book 25 23 Könyv Book 23 2 Egyéb konferenciaközlemény Conference paper 31 1 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 13 6 13 6 2025 0 38 9 38 9 2026 0 36 15 36 15 Q2 false false false false 2024-02-25T07:14:14.793+0000 Népegészségtani Intézet (SE / AOK / I) 5 10 1 5 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 115256774 /api/authorship/115256774 Fekete, Mónika [Fekete, Mónika (Népegészségtan), author] Department of Public Health (SU / FM / I) 1 0.2 true false false Author 10058020 /api/author/10058020 Mónika Fekete (Népegészségtan) Fekete Mónika true 10058020 true Fekete Mónika true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115256775 /api/authorship/115256775 Major, Dávid [Major, Dávid (Megelőző orvostan...), author] Department of Public Health (SU / FM / I) 2 0.2 false false false Author 10080371 /api/author/10080371 Dávid Major (Megelőző orvostan, társadalomegészségtan) Major Dávid true true Major Dávid true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115256776 /api/authorship/115256776 Fehér, Ágnes [Fehér, Ágnes (Népegészségtan), author] Department of Public Health (SU / FM / I) 3 0.2 false false false Author 10065641 /api/author/10065641 Ágnes Fehér (Népegészségtan) Fehér Ágnes true true Fehér Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115256777 /api/authorship/115256777 Fazekas-Pongor, Vince ✉ [Fazekas-Pongor, Vince (népegészségtan), author] Department of Public Health (SU / FM / I) 4 0.2 false false true Author 10035785 /api/author/10035785 Vince Fazekas-Pongor (népegészségtan) Fazekas-Pongor Vince true 10035785 true Fazekas-Pongor Vince true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115256778 /api/authorship/115256778 Lehoczki, Andrea [Lehoczki, Andrea Marianna (hematológia, belg...), author] Department of Public Health (SU / FM / I) 5 0.2 false true false Author 10089009 /api/author/10089009 Andrea Marianna Lehoczki (hematológia, belgyógyászat) Lehoczki Andrea Marianna true true Lehoczki Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25739072 /api/publicationidentifier/25739072 DOI: 10.3389/pore.2024.1611623 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/pore.2024.1611623 https://doi.org/10.3389/pore.2024.1611623 false true PublicationIdentifier 25875498 /api/publicationidentifier/25875498 WoS: 001177996500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS 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Bua 2006: Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers., Am J Hum Genet, 79, p. 469, DOI: 10.1086/507132 168 10.1086/507132 false true Reference 50439754 /api/reference/50439754 169. Swift 2022: DNA damage-induced degradation of Sp1 promotes cellular senescence., Geroscience, 44, p. 683, DOI: 10.1007/s11357-021-00456-5 169 10.1007/s11357-021-00456-5 false true Reference 50439755 /api/reference/50439755 170. Han 2022: Potential regulators of the senescence-associated secretory phenotype during senescence and aging., J Gerontol A Biol Sci Med Sci, 77, p. 2207, DOI: 10.1093/gerona/glac097 170 10.1093/gerona/glac097 false true Reference 50439756 /api/reference/50439756 171. Matacchione 2022: Senescent macrophages in the human adipose tissue as a source of inflammaging., Geroscience, 44, p. 1941, DOI: 10.1007/s11357-022-00536-0 171 10.1007/s11357-022-00536-0 false true Reference 50439757 /api/reference/50439757 172. Fielding 2022: Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study., Geroscience, 44, p. 2757, DOI: 10.1007/s11357-022-00685-2 172 10.1007/s11357-022-00685-2 false true Reference 50439758 /api/reference/50439758 173. Kavanagh 2021: Biomarkers of senescence in non-human primate adipose depots relate to aging., Geroscience, 43, p. 343, DOI: 10.1007/s11357-020-00230-z 173 10.1007/s11357-020-00230-z false true Reference 50439759 /api/reference/50439759 174. Karin 2021: Senescent cell accumulation mechanisms inferred from parabiosis., Geroscience, 43, p. 329, DOI: 10.1007/s11357-020-00286-x 174 10.1007/s11357-020-00286-x false true Reference 50439760 /api/reference/50439760 175. Hense 2022: Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary., Geroscience, 44, p. 1747, DOI: 10.1007/s11357-022-00573-9 175 10.1007/s11357-022-00573-9 false true Reference 50439761 /api/reference/50439761 176. Dungan 2022: Senolytic treatment rescues blunted muscle hypertrophy in old mice., Geroscience, 44, p. 1925, DOI: 10.1007/s11357-022-00542-2 176 10.1007/s11357-022-00542-2 false true Reference 50439762 /api/reference/50439762 177. Iijima 2022: Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice., J Gerontol A Biol Sci Med Sci, 77, p. 1321, DOI: 10.1093/gerona/glab386 177 10.1093/gerona/glab386 false true Reference 50439763 /api/reference/50439763 178. Csipo 2020: Astrocyte senescence contributes to cognitive decline., Geroscience, 42, p. 51, DOI: 10.1007/s11357-019-00140-9 178 10.1007/s11357-019-00140-9 false true Reference 50439764 /api/reference/50439764 179. Kiss 2020: Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain., Geroscience, 42, p. 429, DOI: 10.1007/s11357-020-00177-1 179 10.1007/s11357-020-00177-1 false true Reference 50439765 /api/reference/50439765 180. Tarantini 2021: Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice., Geroscience, 43, p. 2427, DOI: 10.1007/s11357-021-00440-z 180 10.1007/s11357-021-00440-z false true Reference 50439766 /api/reference/50439766 181. Chae 2021: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration., Geroscience, 43, p. 2809, DOI: 10.1007/s11357-021-00457-4 181 10.1007/s11357-021-00457-4 false true Reference 50439767 /api/reference/50439767 182. Park 2022: Metformin alleviates ionizing radiation-induced senescence by restoring BARD1-mediated DNA repair in human aortic endothelial cells., Exp Gerontol, 160, p. 111706, DOI: 10.1016/j.exger.2022.111706 182 10.1016/j.exger.2022.111706 false true Reference 50439768 /api/reference/50439768 183. 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Kiss 2022: Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain., Geroscience, 44, p. 661, DOI: 10.1007/s11357-022-00521-7 192 10.1007/s11357-022-00521-7 false true Reference 50439778 /api/reference/50439778 193. Thadathil 2021: Necroptosis increases with age in the brain and contributes to age-related neuroinflammation., Geroscience, 43, p. 2345, DOI: 10.1007/s11357-021-00448-5 193 10.1007/s11357-021-00448-5 false true Reference 50439779 /api/reference/50439779 194. Mehdipour 2021: Plasma dilution improves cognition and attenuates neuroinflammation in old mice., Geroscience, 43, p. 1, DOI: 10.1007/s11357-020-00297-8 194 10.1007/s11357-020-00297-8 false true Reference 50439780 /api/reference/50439780 195. Liang 2022: Inflammaging: the ground for sarcopenia?., Exp Gerontol, 168, p. 111931, DOI: 10.1016/j.exger.2022.111931 195 10.1016/j.exger.2022.111931 false true Reference 50439781 /api/reference/50439781 196. Luo 2022: Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study., Geroscience, 44, p. 2259, DOI: 10.1007/s11357-022-00602-7 196 10.1007/s11357-022-00602-7 false true Reference 50439782 /api/reference/50439782 197. Lu 2022: Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults., Geroscience, 44, p. 1489, DOI: 10.1007/s11357-022-00554-y 197 10.1007/s11357-022-00554-y false true Reference 50439783 /api/reference/50439783 198. Jimenez 2022: Screening health-promoting compounds for their capacity to induce the activity of FOXO3., J Gerontol A Biol Sci Med Sci, 77, p. 1485, DOI: 10.1093/gerona/glab265 198 10.1093/gerona/glab265 false true Reference 50439784 /api/reference/50439784 199. Li 2022: Metformin protects against inflammation, oxidative stress to delay poly I:C-induced aging-like phenomena in the gut of an annual fish., J Gerontol A Biol Sci Med Sci, 77, p. 276, DOI: 10.1093/gerona/glab298 199 10.1093/gerona/glab298 false true Reference 50439785 /api/reference/50439785 200. Brazao 2022: Melatonin regulates antioxidant defense and inflammatory response by activating Nrf2-dependent mechanisms and inhibiting NFkappaB expression in middle-aged T. cruzi infected rats., Exp Gerontol, 167, p. 111895, DOI: 10.1016/j.exger.2022.111895 200 10.1016/j.exger.2022.111895 false true Reference 50439786 /api/reference/50439786 201. Caldeira 2021: Resveratrol: change of SIRT 1 and AMPK signaling pattern during the aging process., Exp Gerontol, 146, p. 111226, DOI: 10.1016/j.exger.2021.111226 201 10.1016/j.exger.2021.111226 false true Reference 50439787 /api/reference/50439787 202. Gregory 2023: Mediterranean diet and structural neuroimaging biomarkers of Alzheimer's and cerebrovascular disease: a systematic review., Exp Gerontol, 172, p. 112065, DOI: 10.1016/j.exger.2022.112065 202 10.1016/j.exger.2022.112065 false true Reference 50439788 /api/reference/50439788 203. Chenhuichen 2022: Impact of probiotics and prebiotics in the modulation of the major events of the aging process: a systematic review of randomized controlled trials., Exp Gerontol, 164, p. 111809, DOI: 10.1016/j.exger.2022.111809 203 10.1016/j.exger.2022.111809 false true Reference 50439789 /api/reference/50439789 204. 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Tarantini 2019: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice., Redox Biol, 24, p. 101192, DOI: 10.1016/j.redox.2019.101192 218 10.1016/j.redox.2019.101192 false true Reference 50439804 /api/reference/50439804 219. Csiszar 2019: Role of endothelial NAD+ deficiency in age-related vascular dysfunction., Am J Physiol Heart Circ Physiol, 316, p. H1253, DOI: 10.1152/ajpheart.00039.2019 219 10.1152/ajpheart.00039.2019 false true Reference 50439805 /api/reference/50439805 220. Kiss 2020: Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects., Geroscience, 42, p. 527, DOI: 10.1007/s11357-020-00165-5 220 10.1007/s11357-020-00165-5 false true Reference 50439806 /api/reference/50439806 221. Tarantini 2019: Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging., Geroscience, 41, p. 533, DOI: 10.1007/s11357-019-00101-2 221 10.1007/s11357-019-00101-2 false true Reference 50439807 /api/reference/50439807 222. Das 2018: Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging., Cell, 173, p. 74, DOI: 10.1016/j.cell.2018.02.008 222 10.1016/j.cell.2018.02.008 false true Reference 50439808 /api/reference/50439808 223. Clement 2018: The plasma NAD(+) metabolome is dysregulated in "normal" aging., Rejuvenation Res, 22, p. 121, DOI: 10.1089/rej.2018.2077 223 10.1089/rej.2018.2077 false true Reference 50439809 /api/reference/50439809 224. 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Blair 2021: Acute respiratory distress in aged, SARS-CoV-2-infected african green monkeys but not rhesus macaques., Am J Pathol, 191, p. 274, DOI: 10.1016/j.ajpath.2020.10.016 227 10.1016/j.ajpath.2020.10.016 false true Reference 50439813 /api/reference/50439813 228. Mulka 2022: Progression and resolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in golden Syrian hamsters., Am J Pathol, 192, p. 195, DOI: 10.1016/j.ajpath.2021.10.009 228 10.1016/j.ajpath.2021.10.009 false true Reference 50439814 /api/reference/50439814 229. Gustine 2021: Immunopathology of hyperinflammation in COVID-19., Am J Pathol, 191, p. 4, DOI: 10.1016/j.ajpath.2020.08.009 229 10.1016/j.ajpath.2020.08.009 false true Reference 50439815 /api/reference/50439815 230. Johnson 2022: Coronavirus disease 2019 (COVID-19) coronary vascular thrombosis: correlation with neutrophil but not endothelial activation., Am J Pathol, 192, p. 112, DOI: 10.1016/j.ajpath.2021.09.004 230 10.1016/j.ajpath.2021.09.004 false true Reference 50439816 /api/reference/50439816 231. Martin 2022: Lung injury and repair in coronavirus disease 2019-related acute lung injury., Am J Pathol, 192, p. 406, DOI: 10.1016/j.ajpath.2022.01.001 231 10.1016/j.ajpath.2022.01.001 false true Reference 50439817 /api/reference/50439817 232. Nicosia 2021: COVID-19 vasculopathy: mounting evidence for an indirect mechanism of endothelial injury., Am J Pathol, 191, p. 1374, DOI: 10.1016/j.ajpath.2021.05.007 232 10.1016/j.ajpath.2021.05.007 false true Reference 50439818 /api/reference/50439818 233. Pujadas 2021: Molecular profiling of coronavirus disease 2019 (COVID-19) autopsies uncovers novel disease mechanisms., Am J Pathol, 191, p. 2064, DOI: 10.1016/j.ajpath.2021.08.009 233 10.1016/j.ajpath.2021.08.009 false true Reference 50439819 /api/reference/50439819 234. Salazar 2021: Significantly decreased mortality in a large cohort of coronavirus disease 2019 (COVID-19) patients transfused early with convalescent plasma containing high-titer anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein IgG., Am J Pathol, 191, p. 90, DOI: 10.1016/j.ajpath.2020.10.008 234 10.1016/j.ajpath.2020.10.008 false true Reference 50439820 /api/reference/50439820 235. Ting 2022: Fatal COVID-19 and non-COVID-19 acute respiratory distress syndrome is associated with incomplete alveolar type 1 epithelial cell differentiation from the transitional state without fibrosis., Am J Pathol, 192, p. 454, DOI: 10.1016/j.ajpath.2021.11.014 235 10.1016/j.ajpath.2021.11.014 false true Reference 50439821 /api/reference/50439821 236. Whitmore 2021: Understanding the role of blood vessels in the neurologic manifestations of coronavirus disease 2019 (COVID-19)., Am J Pathol, 191, p. 1946, DOI: 10.1016/j.ajpath.2021.04.017 236 10.1016/j.ajpath.2021.04.017 false true Reference 50439822 /api/reference/50439822 237. Fagyas 2022: The majority of severe COVID-19 patients develop anti-cardiac autoantibodies., Geroscience, 44, p. 2347, DOI: 10.1007/s11357-022-00649-6 237 10.1007/s11357-022-00649-6 false true Reference 50439823 /api/reference/50439823 238. Moccia 2020: COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches., Geroscience, 42, p. 1021, DOI: 10.1007/s11357-020-00198-w 238 10.1007/s11357-020-00198-w false true Reference 50439824 /api/reference/50439824 239. Danics 2021: A COVID-19-association-dependent categorization of death causes in 100 autopsy cases., Geroscience, 43, p. 2265, DOI: 10.1007/s11357-021-00451-w 239 10.1007/s11357-021-00451-w false true Reference 50439825 /api/reference/50439825 240. Peterfi 2022: Comorbidities and increased mortality of COVID-19 among the elderly: a systematic review., Physiol Int, 109, p. 163, DOI: 10.1556/2060.2022.00206 240 10.1556/2060.2022.00206 false true Reference 50439826 /api/reference/50439826 241. Gado 2022: COVID-19 and the elderly., Physiol Int, 109, p. 177, DOI: 10.1556/2060.2022.00203 241 10.1556/2060.2022.00203 false true Reference 50439827 /api/reference/50439827 242. Bello-Chavolla 2021: Unequal impact of structural health determinants and comorbidity on COVID-19 severity and lethality in older Mexican adults: considerations beyond chronological aging., J Gerontol A Biol Sci Med Sci, 76, p. e52, DOI: 10.1093/gerona/glaa163 242 10.1093/gerona/glaa163 false true Reference 50439828 /api/reference/50439828 243. Esme 2021: Older adults with coronavirus disease 2019: a nationwide study in Turkey., J Gerontol A Biol Sci Med Sci, 76, p. e68, DOI: 10.1093/gerona/glaa219 243 10.1093/gerona/glaa219 false true Reference 50439829 /api/reference/50439829 244. Farrelly 2021: The COVID-19 pandemic, biogerontology, and the ageing of humanity., J Gerontol A Biol Sci Med Sci, 76, p. e92, DOI: 10.1093/gerona/glab027 244 10.1093/gerona/glab027 false true Reference 50439830 /api/reference/50439830 245. 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Garcia-Torre 2022: Surviving older patients show preserved cellular and humoral immunological memory several months after SARS-CoV-2 infection., J Gerontol A Biol Sci Med Sci, 77, p. 33, DOI: 10.1093/gerona/glab206 257 10.1093/gerona/glab206 false true Reference 50439843 /api/reference/50439843 258. Justice 2021: A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin., Geroscience, 43, p. 1093, DOI: 10.1007/s11357-020-00261-6 258 10.1007/s11357-020-00261-6 false true Reference 50439844 /api/reference/50439844 259. Pence 2020: Severe COVID-19 and aging: are monocytes the key?., Geroscience, 42, p. 1051, DOI: 10.1007/s11357-020-00213-0 259 10.1007/s11357-020-00213-0 false true Reference 50439845 /api/reference/50439845 260. 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Jeon 2017: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment., Nat Med, 23, p. 775, DOI: 10.1038/nm.4324 266 10.1038/nm.4324 false true Reference 50439852 /api/reference/50439852 267. Kim 2019: Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice., Aging Cell, 18, p. e12923, DOI: 10.1111/acel.12923 267 10.1111/acel.12923 false true Reference 50439853 /api/reference/50439853 268. Istvan 2021: Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment., Geroscience, 43, p. 1703, DOI: 10.1007/s11357-021-00392-4 268 10.1007/s11357-021-00392-4 false true Reference 50439854 /api/reference/50439854 269. Czako 2020: Retinal biomarkers for Alzheimer's disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis., Geroscience, 42, p. 1499, DOI: 10.1007/s11357-020-00252-7 269 10.1007/s11357-020-00252-7 false true Reference 50439855 /api/reference/50439855 270. Drewelies 2022: Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts., Geroscience, 44, p. 2685, DOI: 10.1007/s11357-022-00662-9 270 10.1007/s11357-022-00662-9 false true Reference 50439856 /api/reference/50439856 271. Cummings 2022: Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age., Geroscience, 44, p. 2925, DOI: 10.1007/s11357-022-00671-8 271 10.1007/s11357-022-00671-8 false true Reference 50439857 /api/reference/50439857 272. Amgalan 2022: Brain age estimation reveals older adults' accelerated senescence after traumatic brain injury., Geroscience, 44, p. 2509, DOI: 10.1007/s11357-022-00597-1 272 10.1007/s11357-022-00597-1 false true Reference 50439858 /api/reference/50439858 273. Kwon 2021: A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge., Geroscience, 43, p. 2795, DOI: 10.1007/s11357-021-00480-5 273 10.1007/s11357-021-00480-5 false true Reference 50439859 /api/reference/50439859 274. Crimmins 2021: Quest for a summary measure of biological age: the health and retirement study., Geroscience, 43, p. 395, DOI: 10.1007/s11357-021-00325-1 274 10.1007/s11357-021-00325-1 false true Reference 50439860 /api/reference/50439860 275. 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Geroscience and pathology: a new frontier in understanding age-related diseases. (2024) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 30<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10058020"><a href="/gui2/?type=authors&mode=browse&sel=10058020" target="_blank">Fekete Mónika (<span class="authorship-author-name">Fekete Mónika</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080371"><a href="/gui2/?type=authors&mode=browse&sel=10080371" target="_blank">Major Dávid (<span class="authorship-author-name">Major Dávid</span> <span class="authorAux-mtmt"> Megelőző orvostan, társadalomegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065641"><a href="/gui2/?type=authors&mode=browse&sel=10065641" target="_blank">Fehér Ágnes (<span class="authorship-author-name">Fehér Ágnes</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035785"><a href="/gui2/?type=authors&mode=browse&sel=10035785" target="_blank">Fazekas-Pongor Vince ✉ (<span class="authorship-author-name">Fazekas-Pongor Vince</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089009"><a href="/gui2/?type=authors&mode=browse&sel=10089009" target="_blank">Lehoczki Andrea (<span class="authorship-author-name">Lehoczki Andrea Marianna</span> <span class="authorAux-mtmt"> hematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34684374" target="_blank">Geroscience and pathology: a new frontier in understanding age-related diseases</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">30</span> <span class="page"> Paper 1611623. 14 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/pore.2024.1611623" target="_blank" href="https://doi.org/10.3389/pore.2024.1611623"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001177996500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001177996500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85186871818" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85186871818"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38463143" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38463143&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.por-journal.com/articles/10.3389/pore.2024.1611623/full" target="_blank" href="https://www.por-journal.com/articles/10.3389/pore.2024.1611623/full"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 87</span> | Independent citation: 30 | Self citation: 57 | Unknown citation: 0 | Number of citations in WoS: 53 | Number of citations in Scopus:&nbsp;54 | WoS/Scopus assigned:&nbsp;57 | Number of citations with DOI:&nbsp;62 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34684374&sort=publishedYear,desc&sort=title"> Number of cited publications: 43 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34684374</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Funder: NRDIO, (101004093/EUniWell/EAC-A02- 2019/EAC-A02-2019-1) </div> <div class="lastModified">Last Modified: 2026.06.05. 15:12 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Public Health, Semmelweis University, Budapest, Hungary Departments of Hematology and Stem Cell Transplantation, South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Saint Ladislaus Campus, Budapest, Hungary Export Date: 25 July 2025; Cited By: 33; Correspondence Address: V. Fazekas-Pongor; Departmen...</pre> </div></div>