https://m2.mtmt.hu/ eng 2026-05-11 04:32 JournalArticle 34681008 APPROVED true Funding Agency and Grant Number: Hungarian National Scientific Research Fund [FK-138475]; Hungarian National Scientific Research Fund (OTKA); Egis Pharmaceuticals PLC Funding text: This research was supported by the Hungarian National Scientific Research Fund (OTKA) grant FK-138475. The financial support from Egis Pharmaceuticals PLC is also gratefully acknowledged. 0 false 2026-04-24T07:41:19.192+0000 2026-02-10T09:39:30.272+0000 2024-02-23T14:04:53.005+0000 true 10044851 Szilágyi Botond /api/author/10044851 Author Botond Szilágyi (Folyamatmérnök, vegyészmérnök) true 10044851 2026-02-10T09:39:30.133+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Orosz, Álmos true true /api/journal/1933 REVIEWED INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 0888-5885 1520-5045 0196-4305 true false 1933 false 1933 true 0888-5885 1520-5045 Journal FOREIGN 63 9 4068 4082 4068 15 2024 Well-designed and operated pharmaceutical crystallization can enhance the key features of the active pharmaceutical ingredients, which can be taken to the next level by a model-based design. Model development not only requires computer implementation, kinetic identification, and advanced programming skills but also a suitable number of information-rich experiments. Numerous products have been crystallized for a long time, with many related laboratory-scale experiments and plant-scale manufacturing data accumulated from past developments and productions. The question arises: can these historical data be utilized to build process models, which can be used subsequently to optimize processes? We aim to demonstrate in this study that this approach can be feasible. To illustrate this, we used the data of two commercial crystallization production campaigns, totaling 16 industrial crystallizations, and six laboratory experiments, four of which were formerly performed for different purposes. Our tailored PBM involves primary and secondary nucleation, crystal growth, and dissolution and can simultaneously reproduce laboratory- and plant-scale dynamics. Despite relying on nontargeted experiments and measuring/sampling strategy, the estimated parameters were accurate, with an average deviation between the nominal values and 95% confidence interval bonds of 16.1%. The model was employed to construct an optimal design space (DS) for a temperature cycling operation involving, as a constraint, 2, 3, and 4 cycles: the goal was to define a temperature domain with minimal batch time and heating/cooling energy demand that respects the constraints on the product PSD and heating/cooling rates. The problem was solved as a constrained robust optimization, where discrete temperature stamps and corresponding time stamps were optimized. The optimal operation halved the current batch time. The optimized temperature profile was validated on a laboratory scale for two particle size specifications. More expansive DS (1 vs 0.5 h random temperature variation allowed around the nominal temperature profile) was observed to translate to longer batch times (30 vs 25 h) and deeper temperature cycles of 40 vs 20 °C, reflecting a trade-off between nominal performance and robustness. 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(BUTE / FCTB) 1 0.1 true false false Author 10083600 /api/author/10083600 Álmos Orosz (kristályosítás, populációmérleg modellezés) Orosz Álmos true true Orosz Álmos true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230844 /api/authorship/115230844 Szilágyi, Emőke 2 0.1 false false false Szilágyi Emőke true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230845 /api/authorship/115230845 Spaits, András 3 0.1 false false false Spaits András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230846 /api/authorship/115230846 Borsos, Ákos [Borsos, Ákos (Vegyészmérnökség,...), author] Egis Pharmaceuticals Ltd. 4 0.1 false false false Author 10090493 /api/author/10090493 Ákos Borsos (Vegyészmérnökség, kristályosítás és modellezés) Borsos Ákos true true Borsos Ákos true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230847 /api/authorship/115230847 Farkas, Ferenc 5 0.1 false false false Farkas Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230848 /api/authorship/115230848 Markovits, Imre [Markovits, Imre, author] Egis Pharmaceuticals Ltd. 6 0.1 false false false Author 10069137 /api/author/10069137 Imre Markovits Markovits Imre true true Markovits Imre true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230849 /api/authorship/115230849 Százdi, László [Százdi, László (vegyészmérnöki tu...), author] Egis Pharmaceuticals Ltd. 7 0.1 false false false Author 10016346 /api/author/10016346 László Százdi (vegyészmérnöki tudományok) Százdi László true 10016346 true Százdi László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230850 /api/authorship/115230850 Volk, Balázs [Volk, Balázs (Hatóanyag gyártóe...), author] Egis Pharmaceuticals Ltd. 8 0.1 false false false Author 10012714 /api/author/10012714 Balázs Volk (Hatóanyag gyártóeljárás-fejlesztés, heterociklusos vegyületek kémiája, alkaloidok szintézise) Volk Balázs true 10012714 true Volk Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230851 /api/authorship/115230851 Kátainé Fadgyas, Katalin [Kátainé Fadgyas, Katalin (Kémiai tudományok), author] Egis Pharmaceuticals Ltd. 9 0.1 false false false Author 10075363 /api/author/10075363 Katalin Kátainé Fadgyas (Kémiai tudományok) Kátainé Fadgyas Katalin true true Kátainé Fadgyas Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 115230852 /api/authorship/115230852 Szilágyi, Botond ✉ [Szilágyi, Botond (Folyamatmérnök, v...), author] Faculty of Chemical Technology and Biotechnology (BUTE) 10 0.1 false true true Author 10044851 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DOI: 10.1021/cg101556s 1 10.1021/cg101556s false true Reference 50409174 /api/reference/50409174 2. DOI: 10.1205/cerd.82.12.1567.58038 2 10.1205/cerd.82.12.1567.58038 false true Reference 50409175 /api/reference/50409175 3. DOI: 10.1016/j.cherd.2013.07.018 3 10.1016/j.cherd.2013.07.018 false true Reference 50409176 /api/reference/50409176 4. DOI: 10.1021/acs.iecr.9b00071 4 10.1021/acs.iecr.9b00071 false true Reference 50409177 /api/reference/50409177 5. DOI: 10.1021/acs.cgd.0c00434 5 10.1021/acs.cgd.0c00434 false true Reference 50409178 /api/reference/50409178 6. DOI: 10.1016/j.cej.2019.04.109 6 10.1016/j.cej.2019.04.109 false true Reference 50409179 /api/reference/50409179 7. DOI: 10.1016/j.proci.2016.07.008 7 10.1016/j.proci.2016.07.008 false true Reference 50409180 /api/reference/50409180 8. DOI: 10.1016/j.ces.2004.11.062 8 10.1016/j.ces.2004.11.062 false true Reference 50409181 /api/reference/50409181 9. DOI: 10.1021/acs.iecr.2c03731 9 10.1021/acs.iecr.2c03731 false true Reference 50409182 /api/reference/50409182 10. DOI: 10.1016/0009-2509(64)85047-8 10 10.1016/0009-2509(64)85047-8 false true Reference 50409183 /api/reference/50409183 11. DOI: 10.1016/j.ces.2022.117700 11 10.1016/j.ces.2022.117700 false true Reference 50409184 /api/reference/50409184 12. DOI: 10.1021/cg101555u 12 10.1021/cg101555u false true Reference 50409185 /api/reference/50409185 13. DOI: 10.1021/acs.cgd.0c00295 13 10.1021/acs.cgd.0c00295 false true Reference 50409186 /api/reference/50409186 14. DOI: 10.1016/j.cej.2023.142800 14 10.1016/j.cej.2023.142800 false true Reference 50409187 /api/reference/50409187 15. DOI: 10.1021/ie800900f 15 10.1021/ie800900f false true Reference 50409188 /api/reference/50409188 16. DOI: 10.1021/acs.iecr.0c04870 16 10.1021/acs.iecr.0c04870 false true Reference 50409189 /api/reference/50409189 17. DOI: 10.1109/TCST.2011.2160945 17 10.1109/TCST.2011.2160945 false true Reference 50409190 /api/reference/50409190 18. DOI: 10.1016/s0301-7516(01)00044-8 18 10.1016/s0301-7516(01)00044-8 false true Reference 50409191 /api/reference/50409191 19. DOI: 10.1007/BF03402606 19 10.1007/BF03402606 false true Reference 50409192 /api/reference/50409192 20. DOI: 10.1016/j.compchemeng.2022.108024 20 10.1016/j.compchemeng.2022.108024 false true Reference 50409193 /api/reference/50409193 21. DOI: 10.1021/acs.oprd.9b00348 21 10.1021/acs.oprd.9b00348 false true Reference 50409194 /api/reference/50409194 22. DOI: 10.1021/acs.iecr.0c04870 22 10.1021/acs.iecr.0c04870 false true Reference 50409195 /api/reference/50409195 23. DOI: 10.1021/acs.cgd.6b00787 23 10.1021/acs.cgd.6b00787 false true Reference 50409196 /api/reference/50409196 24. DOI: 10.1021/ie00019a002 24 10.1021/ie00019a002 false true Reference 50409197 /api/reference/50409197 25. DOI: 10.1016/j.cej.2023.145257 25 10.1016/j.cej.2023.145257 false true Reference 50409198 /api/reference/50409198 26. DOI: 10.1016/0022-0248(92)90636-W 26 10.1016/0022-0248(92)90636-W false true Reference 50409199 /api/reference/50409199 27. DOI: 10.1021/acs.cgd.9b01240 27 10.1021/acs.cgd.9b01240 false true Reference 50409200 /api/reference/50409200 28. DOI: 10.1002/crat.2170240302 28 10.1002/crat.2170240302 false true Reference 50409201 /api/reference/50409201 29. DOI: 10.1021/acs.cgd.7b01383 29 10.1021/acs.cgd.7b01383 false true Reference 50409202 /api/reference/50409202 30. DOI: 10.1016/S0169-7439(99)00049-0 30 10.1016/S0169-7439(99)00049-0 false true Reference 50409203 /api/reference/50409203 31. DOI: 10.1002/aic.690140121 31 10.1002/aic.690140121 false true Reference 50409204 /api/reference/50409204 32. DOI: 10.3390/cryst11121558 32 10.3390/cryst11121558 false true Reference 50409205 /api/reference/50409205 33. DOI: 10.1016/0022-0248(87)90505-7 33 10.1016/0022-0248(87)90505-7 false true Reference 50409206 /api/reference/50409206 34. DOI: 10.1021/acs.cgd.9b01465 34 10.1021/acs.cgd.9b01465 false true Reference 50409207 /api/reference/50409207 35. DOI: 10.1016/j.ces.2016.07.034 35 10.1016/j.ces.2016.07.034 false true Reference 50409208 /api/reference/50409208 36. DOI: 10.1016/j.cherd.2020.07.011 36 10.1016/j.cherd.2020.07.011 false true Reference 50409209 /api/reference/50409209 37. Fogler H. S. 1999: Elements of Chemical Reaction Engineering 37 false true Reference 50409210 /api/reference/50409210 38. DOI: 10.1002/aic.690200516 38 10.1002/aic.690200516 false true Reference 50409211 /api/reference/50409211 39. Elder D. 2017: ICH Quality Guidelines, p. 579, DOI: 10.1002/9781118971147.ch21 39 10.1002/9781118971147.ch21 false true Reference 50409212 /api/reference/50409212 40. DOI: 10.1016/j.jprocont.2003.07.004 40 10.1016/j.jprocont.2003.07.004 false true Reference 50409213 /api/reference/50409213 41. DOI: 10.1515/zpch-1926-11927 41 10.1515/zpch-1926-11927 false true Reference 50409214 /api/reference/50409214 42. Hall S. 2012: Branan’s Rules of Thumb for Chemical Engineers, p. 257, DOI: 10.1016/B978-0-12-387785-7.00016-5 42 10.1016/B978-0-12-387785-7.00016-5 false true Reference 50409215 /api/reference/50409215 43. DOI: 10.1002/aic.690140121 43 10.1002/aic.690140121 false true Reference 50409216 /api/reference/50409216 44. DOI: 10.1002/aic.690130104 44 10.1002/aic.690130104 false true Reference 50409217 /api/reference/50409217 45. DOI: 10.1002/aic.10228 45 10.1002/aic.10228 false true Reference 50409218 /api/reference/50409218 46. Leveque R. J. 1992: Numerical Methods for Conservation Laws Birkhauser, DOI: 10.1007/978-3-0348-8629-1 46 10.1007/978-3-0348-8629-1 false true Reference 50409219 /api/reference/50409219 47. DOI: 10.48550/arXiv.1604.00772 47 10.48550/arXiv.1604.00772 false true /api/publication/34681008 Orosz Álmos et al. Dynamic Modeling and Optimal Design Space Determination of Pharmaceutical Crystallization Processes: Realizing the Synergy between Off-the-Shelf Laboratory and Industrial Scale Data. (2024) INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 0888-5885 1520-5045 0196-4305 63 9 4068-4082<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10083600"><a href="/gui2/?type=authors&mode=browse&sel=10083600" target="_blank">Orosz Álmos (<span class="authorship-author-name">Orosz Álmos</span> <span class="authorAux-mtmt"> kristályosítás, populációmérleg modellezés</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Chemical Technology and Biotechnology">FCTB</span>/Department of Chemical and Environmental Process Engineering</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szilágyi Emőke </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spaits András </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090493"><a href="/gui2/?type=authors&mode=browse&sel=10090493" target="_blank">Borsos Ákos (<span class="authorship-author-name">Borsos Ákos</span> <span class="authorAux-mtmt"> Vegyészmérnökség, kristályosítás és modellezés</span>) </a> </span> <span class="author-affil">Egis Pharmaceuticals Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Farkas Ferenc </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069137"><a href="/gui2/?type=authors&mode=browse&sel=10069137" target="_blank">Markovits Imre (<span class="authorship-author-name">Markovits Imre</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil">Egis Pharmaceuticals Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016346"><a href="/gui2/?type=authors&mode=browse&sel=10016346" target="_blank">Százdi László (<span class="authorship-author-name">Százdi László</span> <span class="authorAux-mtmt"> vegyészmérnöki tudományok</span>) </a> </span> <span class="author-affil">Egis Pharmaceuticals Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012714"><a href="/gui2/?type=authors&mode=browse&sel=10012714" target="_blank">Volk Balázs (<span class="authorship-author-name">Volk Balázs</span> <span class="authorAux-mtmt"> Hatóanyag gyártóeljárás-fejlesztés, heterociklu...</span>) </a> </span> <span class="author-affil">Egis Pharmaceuticals Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075363"><a href="/gui2/?type=authors&mode=browse&sel=10075363" target="_blank">Kátainé Fadgyas Katalin (<span class="authorship-author-name">Kátainé Fadgyas Katalin</span> <span class="authorAux-mtmt"> Kémiai tudományok</span>) </a> </span> <span class="author-affil">Egis Pharmaceuticals Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044851"><a href="/gui2/?type=authors&mode=browse&sel=10044851" target="_blank">Szilágyi Botond ✉ (<span class="authorship-author-name">Szilágyi Botond</span> <span class="authorAux-mtmt"> Folyamatmérnök, vegyészmérnök</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/Faculty of Chemical Technology and Biotechnology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34681008" target="_blank">Dynamic Modeling and Optimal Design Space Determination of Pharmaceutical Crystallization Processes: Realizing the Synergy between Off-the-Shelf Laboratory and Industrial Scale Data</a></div> <div> <span class="journal-title">INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0888-5885">0888-5885</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1520-5045">1520-5045</a>)</span>: <span class="journal-volume">63</span> <span class="journal-issue">9</span> <span class="page"> pp 4068-4082 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1021/acs.iecr.3c03954" target="_blank" href="https://doi.org/10.1021/acs.iecr.3c03954"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001172834500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001172834500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85186177572" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85186177572"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://pubs.acs.org/doi/10.1021/acs.iecr.3c03954" target="_blank" href="https://pubs.acs.org/doi/10.1021/acs.iecr.3c03954"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Industrial and Manufacturing Engineering&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 8 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34681008&sort=publishedYear,desc&sort=title"> Number of cited publications: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34681008</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2026.02.10. 10:39 Erika Szatmári (BME admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian National Scientific Research Fund [FK-138475]; Hungarian National Scientific Research Fund (OTKA); Egis Pharmaceuticals PLC Funding text: This research was supported by the Hungarian National Scientific Research Fund (OTKA) grant FK-138475. The financial support from Egis Pharmaceuticals PLC is also gratefully acknowledged.</pre> </div></div>