https://m2.mtmt.hu/ hun 2026-09-22 20:43 JournalArticle 34669504 VALIDATED true 0 false 2026-08-13T13:31:48.795+0000 2024-07-25T07:37:13.884+0000 2024-02-22T11:32:25.915+0000 true 10034624 Nagy Sándor /api/author/10034624 Author Nagy Sándor (szülészet-nőgyógyászat) true 10034624 2026-05-08T11:37:50.713+0000 2024-04-03T11:08:33.025+0000 true 10073918 Kovács Marcell /api/admin/10073918 Admin Kovács Marcell (MTMT Közp., admin) true 2024-06-04T22:27:00.868+0000 true 521 Szuper Admin /api/admin/521 Admin Szuper Admin (admin) true Admin 10073918 /api/admin/10073918 Kovács Marcell (MTMT Közp., admin) Kovács Marcell true true 2024-03-22T13:59:27.989+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Gál, Luca true true /api/journal/10023324 REVIEWED FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 15 1321191 1321191 14 2024 Introduction: Preeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset hypertension and proteinuria and it is often associated with fetal intrauterine growth restriction (IUGR). PE leads to long-term health complications, so early diagnosis would be crucial for timely prevention. There are multiple etiologies and subtypes of PE, and this heterogeneity has hindered accurate identification in the presymptomatic phase. Recent investigations have pointed to the potential role of small regulatory RNAs in PE, and these species, which travel in extracellular vesicles (EVs) in the circulation, have raised the possibility of non-invasive diagnostics. The aim of this study was to investigate the behavior of exosomal regulatory small RNAs in the most severe subtype of PE with IUGR. Methods: We isolated exosomal EVs from first-trimester peripheral blood plasma samples of women who later developed preterm PE with IUGR (n=6) and gestational age-matched healthy controls (n=14). The small RNA content of EVs and their differential expression were determined by next-generation sequencing and further validated by quantitative real-time PCR. We also applied the rigorous exceRpt bioinformatics pipeline for small RNA identification, followed by target verification and Gene Ontology analysis. Results: Overall, >2700 small RNAs were identified in all samples and, of interest, the majority belonged to the RNA interference (RNAi) pathways. Among the RNAi species, 16 differentially expressed microRNAs were up-regulated in PE, whereas up-regulated and down-regulated members were equally found among the six identified Piwi-associated RNAs. Gene ontology analysis of the predicted small RNA targets showed enrichment of genes in pathways related to immune processes involved in decidualization, placentation and embryonic development, indicating that dysregulation of the induced small RNAs is connected to the impairment of immune pathways in preeclampsia development. Finally, the subsequent validation experiments revealed that the hsa_piR_016658 piRNA is a promising biomarker candidate for preterm PE associated with IUGR. Discussion: Our rigorously designed study in a homogeneous group of patients unraveled small RNAs in circulating maternal exosomes that act on physiological pathways dysregulated in preterm PE with IUGR. Therefore, our small RNA hits are not only suitable biomarker candidates, but the revealed biological pathways may further inform us about the complex pathology of this severe PE subtype. Funding 2038174 /api/funding/2038174 (LP2014-7/2014,) false true Funding 2038175 /api/funding/2038175 (PC-II-12/2022) false true Funding 2038176 /api/funding/2038176 (ELKH-POC-2022-014) false true Funding 2038177 /api/funding/2038177 (2018-1.2.1-NKP-2018-00005) Támogató: NKFIH false true Funding 2038178 /api/funding/2038178 (FIEK-16-1-2016-0005) false true Funding 2038179 /api/funding/2038179 (K124862) false true Funding 2038180 /api/funding/2038180 (2019-2.1.7-ERANET-2020-00014) false true true 2024 true true true false true false GOLD 2026-08-13 true https://doi.org/10.3389/fimmu.2024.1321191 24 0 24 23 1 23 23 17 19 20 20 19 19 23 1 0 24 23 24 23 0 17 17 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 10 10 10 10 2026 0 11 11 11 11 Q1 false 10000148 false false false 2024-02-21T12:36:52.998+0000 Biológia Doktori Iskola (ELTE / TTK); Egészség- és Sporttudományi Kar (SZE); Génreguláció Kutatócsoport (HRN TTK / MÉI); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Szülészeti és Nőgyógyászati Intézet (DE / ÁOK); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK); Szülészeti és Nőgyógyászati Tanszék (SZE / ESK) 6 69 7 6 0 true 10073918 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 115156945 /api/authorship/115156945 Gál, Luca [Gál, Luca (Molekuláris sejtb...), szerző] Biológia Doktori Iskola (ELTE / TTK); Génreguláció Kutatócsoport (HRN TTK / MÉI) 1 0.167 true false false Author 10073902 /api/author/10073902 Gál Luca (Molekuláris sejtbiológia) Gál Luca true true Gál Luca true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 115156946 /api/authorship/115156946 Fóthi, Ábel [Fóthi, Ábel (genetika), szerző] Génreguláció Kutatócsoport (HRN TTK / MÉI) 2 0.167 false false false Author 10067874 /api/author/10067874 Fóthi Ábel (genetika) Fóthi Ábel true true Fóthi Ábel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 115156947 /api/authorship/115156947 Orosz, Gergő [Orosz, Gergő Balázs (Szülészet Nőgyógy...), szerző] Szülészeti és Nőgyógyászati Intézet (DE / ÁOK) 3 0.16666667 false false false Author 10059724 /api/author/10059724 Orosz Gergő Balázs (Szülészet Nőgyógyászat) Orosz Gergő Balázs true 10059724 true Orosz Gergő true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 115156948 /api/authorship/115156948 Nagy, Sándor [Nagy, Sándor (szülészet-nőgyógy...), szerző] Egészség- és Sporttudományi Kar (SZE); Szülészeti és Nőgyógyászati Tanszék (SZE / ESK) 4 0.16666667 false false false Author 10034624 /api/author/10034624 Nagy Sándor (szülészet-nőgyógyászat) Nagy Sándor true 10034624 true Nagy Sándor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 115156949 /api/authorship/115156949 Than, Nándor Gábor [Than, Nándor Gábor (Rendszerbiológia), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 5 0.167 false false false Author 10011696 /api/author/10011696 Than Nándor Gábor (Rendszerbiológia) Than Nándor Gábor true 10011696 true Than Nándor Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 115156950 /api/authorship/115156950 Orbán, Tamás I. ✉ [Orbán, Tamás I. (Molekuláris sejtb...), szerző] Biológia Doktori Iskola (ELTE / TTK); Génreguláció Kutatócsoport (HRN TTK / MÉI) 6 0.167 false true true Author 10000148 /api/author/10000148 Orbán Tamás I. 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(2024) FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 15<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073902"><a href="/gui2/?type=authors&mode=browse&sel=10073902" target="_blank">Gál Luca (<span class="authorship-author-name">Gál Luca</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Biológia Doktori Iskola; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Génreguláció Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067874"><a href="/gui2/?type=authors&mode=browse&sel=10067874" target="_blank">Fóthi Ábel (<span class="authorship-author-name">Fóthi Ábel</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Génreguláció Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059724"><a href="/gui2/?type=authors&mode=browse&sel=10059724" target="_blank">Orosz Gergő (<span class="authorship-author-name">Orosz Gergő Balázs</span> <span class="authorAux-mtmt"> Szülészet Nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István Egyetem">SZE</span>/Egészség- és Sporttudományi Kar; <span title="Széchenyi István Egyetem">SZE</span>/<span title="Egészség- és Sporttudományi Kar">ESK</span>/Szülészeti és Nőgyógyászati Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000148"><a href="/gui2/?type=authors&mode=browse&sel=10000148" target="_blank">Orbán Tamás I. ✉ (<span class="authorship-author-name">Orbán Tamás I.</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Biológia Doktori Iskola; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Génreguláció Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34669504" target="_blank">Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">15</span> <span class="page"> Paper 1321191. 14 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2024.1321191" target="_blank" href="https://doi.org/10.3389/fimmu.2024.1321191"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001177850500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001177850500001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="121140" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/121140"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85186948872" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85186948872"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38455065" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38455065&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85186948872?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85186948872?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 24</span> | Független: 23 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 17 | Scopus jelölt:&nbsp;19 | WoS/Scopus jelölt:&nbsp;20 | DOI jelölt:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34669504&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 17 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34669504</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2014-7/2014,), (PC-II-12/2022), (ELKH-POC-2022-014), (2018-1.2.1-NKP-2018-00005) Támogató: NKFIH, (FIEK-16-1-2016-0005), (K124862), (2019-2.1.7-ERANET-2020-00014) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/34669504/notduplums">1 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2024.07.25. 09:37 Reményiné Kállai Zsuzsa (DE admin 4) </div> <div class="lockedBy">Központi kezelésű 2024.03.22. 14:59 Kovács Marcell (MTMT Közp., admin) </div> </div></div>