https://m2.mtmt.hu/ hun 2026-09-21 02:13 JournalArticle 34644013 VALIDATED true Department of Molecular Biology, Semmelweis University, Budapest, Hungary Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Turbine Ltd, Budapest, Hungary Export Date: 17 June 2024 CODEN: CMLSF Correspondence Address: Csermely, P.; Department of Molecular Biology, Hungary; email: csermely.peter@med.semmelweis-univ.hu 0 false 2026-09-07T14:33:18.234+0000 2024-03-18T07:53:19.860+0000 2024-02-20T11:59:48.125+0000 true 10063755 Keresztes Dávid /api/author/10063755 Author true 10063755 2026-05-06T11:11:01.982+0000 2024-03-18T07:53:20.146+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Veres, Tamás Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more? true true /api/journal/11507 REVIEWED true false 11507 false 11507 true 1420-682X 1420-9071 Journal FOREIGN 81 1 97 97 13 2024 Recent findings show that single, non-neuronal cells are also able to learn signalling responses developing cellular memory. In cellular learning nodes of signalling networks strengthen their interactions e.g. by the conformational memory of intrinsically disordered proteins, protein translocation, miRNAs, lncRNAs, chromatin memory and signalling cascades. This can be described by a generalized, unicellular Hebbian learning process, where those signalling connections, which participate in learning, become stronger. Here we review those scenarios, where cellular signalling is not only repeated in a few times (when learning occurs), but becomes too frequent, too large, or too complex and overloads the cell. This leads to desensitisation of signalling networks by decoupling signalling components, receptor internalization, and consequent downregulation. These molecular processes are examples of anti-Hebbian learning and ‘forgetting’ of signalling networks. Stress can be perceived as signalling overload inducing the desensitisation of signalling pathways. Ageing occurs by the summative effects of cumulative stress downregulating signalling. We propose that cellular learning desensitisation, stress and ageing may be placed along the same axis of more and more intensive (prolonged or repeated) signalling. We discuss how cells might discriminate between repeated and unexpected signals, and highlight the Hebbian and anti-Hebbian mechanisms behind the fold-change detection in the NF- κ B signalling pathway. We list drug design methods using Hebbian learning (such as chemically-induced proximity) and clinical treatment modalities inducing (cancer, drug allergies) desensitisation or avoiding drug-induced desensitisation. A better discrimination between cellular learning, desensitisation and stress may open novel directions in drug design, e.g. helping to overcome drug resistance. Funding 2037586 /api/funding/2037586 false true Funding 2037587 /api/funding/2037587 false true Funding 2037588 /api/funding/2037588 false true Funding 2037589 /api/funding/2037589 false true true true 2024 true true true false true false NONE 2026-09-07 false 10 0 10 8 2 10 10 9 10 10 10 8 8 8 2 0 10 8 10 8 0 8 8 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat 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class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10094388"><a href="/gui2/?type=authors&mode=browse&sel=10094388" target="_blank">Veres Tamás (<span class="authorship-author-name">Veres Tamás</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088319"><a href="/gui2/?type=authors&mode=browse&sel=10088319" target="_blank">Kerestély Márk<sup>*</sup> (<span class="authorship-author-name">Kerestély Márk</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072470"><a href="/gui2/?type=authors&mode=browse&sel=10072470" target="_blank">Kovács Borbála M. (<span class="authorship-author-name">Kovács Borbála</span> <span class="authorAux-mtmt"> Biológiai hálózatok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063755"><a href="/gui2/?type=authors&mode=browse&sel=10063755" target="_blank">Keresztes Dávid (<span class="authorship-author-name">Keresztes Dávid</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078255"><a href="/gui2/?type=authors&mode=browse&sel=10078255" target="_blank">Schulc Klára (<span class="authorship-author-name">Schulc Klára</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seitz Erik </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049810"><a href="/gui2/?type=authors&mode=browse&sel=10049810" target="_blank">Vassy Zsolt (<span class="authorship-author-name">Vassy Zsolt</span> <span class="authorAux-mtmt"> informatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050101"><a href="/gui2/?type=authors&mode=browse&sel=10050101" target="_blank">Veres Dániel V. (<span class="authorship-author-name">Veres Dániel</span> <span class="authorAux-mtmt"> Molekuláris orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1035707"><a href="/gui2/?type=authors&mode=browse&sel=1035707" target="_blank">Csermely Peter ✉ (<span class="authorship-author-name">Csermely Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34644013" target="_blank">Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?</a></div> <div> <span class="journal-title">CELLULAR AND MOLECULAR LIFE SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-682X">1420-682X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-9071">1420-9071</a>)</span>: <span class="journal-volume">81</span> <span class="journal-issue">1</span> <span class="page"> Paper 97. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00018-024-05112-7" target="_blank" href="https://doi.org/10.1007/s00018-024-05112-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001169720400002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001169720400002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85185513445" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185513445"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38372750" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38372750&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85185513445?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85185513445?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 8 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34644013&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34644013</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K131458), (TKP2021-EGA-24), (Molecular Biology Thematic Programme of Semmelweis University), (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2024.03.18. 08:53 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Molecular Biology, Semmelweis University, Budapest, Hungary Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Turbine Ltd, Budapest, Hungary Export Date: 17 June 2024 CODEN: CMLSF Correspondence Address: ...</pre> </div></div>