https://m2.mtmt.hu/ hun 2026-09-23 00:35 JournalArticle 34641076 ADMIN_APPROVED true 0 false 2026-08-04T11:24:12.608+0000 2025-06-01T07:59:07.117+0000 2024-02-20T07:32:51.820+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2024-07-02T11:41:38.212+0000 2024-07-02T11:41:38.212+0000 2025-01-24T08:41:50.445+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tömböl, Zsófia Multiple bronchial carcinoids associated with Cowden syndrome. true true /api/journal/12039 REVIEWED true false 12039 false 12039 true 1355-008X 1559-0100 Journal FOREIGN 84 3 880 884 880 5 2024 Cowden syndrome (CS) is a rare genetic condition due to the various germline mutations in the phosphatase and tensin homologue on chromosome ten (PTEN) tumour suppressor gene. As a result, CS is characterised by an increased risk of developing various benign and malignant tumours, such as thyroid, breast, endometrial and urogenital neoplasms, as well as gastrointestinal tract tumours. However, the neuroendocrine tumour association with CS is not elucidated yet. We present a case of a 46-year-old male patient diagnosed with testicular seminoma and follicular thyroid cancer in his medical history. Our patient met the clinical diagnostic criteria of Cowden syndrome. Genetic analysis established the clinical diagnosis; a known heterozygous PTEN mutation was detected [PTEN (LRG_311t1)c.388 C > T (p.Arg130Ter)]. Incidentally, he was also seen with multiple pulmonary lesions during his oncological follow-up. A video-assisted thoracoscopic left lingula wedge resection and later resections from the right lung were performed. Histological findings revealed typical pulmonary carcinoid tumours and smaller tumorlets. Somatostatin receptor SPECT-CT, 18F-FDG-PET-CT and 18F-FDOPA-PET-CT scans and endoscopy procedures could not identify any primary tumours in other locations. Our patient is the first published case of Cowden syndrome, associated with multifocal pulmonary carcinoids. Besides multiple endocrine neoplasia type 1, we propose Cowden syndrome as another hereditary condition predisposing to multiple pulmonary tumorlets and carcinoid tumours. Funding 2037375 /api/funding/2037375 false true true 2024 true true true false true false NONE 2026-08-04 false 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 0 0 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 0 1 0 Q2 false false false false 2024-05-20T06:32:59.786+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K); Nukleáris Medicina Tanszék (SE / AOK / K / OKK); Országos Onkológiai Intézet; Patológiai, Igazságügyi és Biztosítási Orvostan... 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false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114920531 /api/authorship/114920531 10 0.091 false false false Author 10023807 /api/author/10023807 Borka Katalin true 10023807 true Borka Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114920532 /api/authorship/114920532 11 0.091 false true true Author 10014760 /api/author/10014760 Tóth Miklós true 10014760 true Tóth Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25627145 /api/publicationidentifier/25627145 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s12020-024-03693-8 https://doi.org/10.1007/s12020-024-03693-8 false true PublicationIdentifier 25749091 /api/publicationidentifier/25749091 PlainSource 1 /api/publicationsource/1 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38353885&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Keyword 1754426 /api/keyword/1754426 true true Keyword 2033579 /api/keyword/2033579 true true Keyword 3331739 /api/keyword/3331739 true true SjrRating 11462121 /api/sjrrating/11462121 50 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true Q2 DIRECT true true /api/publication/34641076 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10074404"><a href="/gui2/?type=authors&mode=browse&sel=10074404" target="_blank">Tömböl Zsófia (<span class="authorship-author-name">Tömböl Zsófia</span> <span class="authorAux-mtmt"> belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043702"><a href="/gui2/?type=authors&mode=browse&sel=10043702" target="_blank">Tőke Judit<sup>*</sup> (<span class="authorship-author-name">Tőke Judit</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóth Géza </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031611"><a href="/gui2/?type=authors&mode=browse&sel=10031611" target="_blank">Varga Zsolt (<span class="authorship-author-name">Varga Zsolt</span> <span class="authorAux-mtmt"> nukleáris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Nukleáris Medicina Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balázs Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062288"><a href="/gui2/?type=authors&mode=browse&sel=10062288" target="_blank">Tóth Erika (<span class="authorship-author-name">Tóth Erika</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043461"><a href="/gui2/?type=authors&mode=browse&sel=10043461" target="_blank">Gergely Lajos (<span class="authorship-author-name">Gergely Lajos</span> <span class="authorAux-mtmt"> Hematológia, Immunológia, Belgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Danihel Ľudovít </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012260"><a href="/gui2/?type=authors&mode=browse&sel=10012260" target="_blank">Medvecz Márta (<span class="authorship-author-name">Medvecz Márta</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023807"><a href="/gui2/?type=authors&mode=browse&sel=10023807" target="_blank">Borka Katalin (<span class="authorship-author-name">Borka Katalin</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014760"><a href="/gui2/?type=authors&mode=browse&sel=10014760" target="_blank">Tóth Miklós ✉ (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34641076" target="_blank">Multiple bronchial carcinoids associated with Cowden syndrome.</a></div> <div> <span class="journal-title">ENDOCRINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1355-008X">1355-008X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1559-0100">1559-0100</a>)</span>: <span class="journal-volume">84</span> <span class="journal-issue">3</span> <span class="page"> pp 880-884 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s12020-024-03693-8" target="_blank" href="https://doi.org/10.1007/s12020-024-03693-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001161646900002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001161646900002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85185135405" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185135405"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38353885" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38353885&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34641076</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK_131916/2019) </div> <div class="lastModified">Utolsó módosítás: 2025.06.01. 09:59 Gergely Lajos (Hematológia, Immunológia, Belgyógyászat) </div> </div></div>