To review the risk of endophthalmitis in same-day bilateral anti-VEGF injections.We
searched 12 literature databases for studies on the risk of endophthalmitis after
same-day bilateral intravitreal anti-VEGF injections. Data extraction was made independently
by two authors and discussed afterward until reaching consensus.Seventeen studies
were included with a total of 138,478 intravitreal anti-VEGF injections (69,239 bilateral
injections sessions) given in at least 7579 patients. In total, 33 cases of endophthalmitis
had occurred, and no cases were bilateral. The incidence of endophthalmitis ranged
from 0 to 0.53% per intravitreal injection across studies.We suggest that clinicians
can consider same-day treatment of both eyes of patients in need of bilateral intravitreal
anti-VEGF injection therapy, but larger studies are needed to quantify the exact risk
of endophthalmitis.
