https://m2.mtmt.hu/ eng 2026-09-22 13:36 JournalArticle 34630550 APPROVED true 0 false 2026-01-04T09:02:07.588+0000 2024-03-19T12:28:25.377+0000 2024-02-19T11:02:30.916+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2024-03-19T12:28:25.387+0000 2024-03-19T12:28:25.387+0000 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1268360 Conference paper in journal true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1268360 Konferenciaközlemény SubType 109 true 1268360 true 1 /api/category/1 Category true 1 Hochmair, Maximilian J Unmet needs in EGFR exon 20 insertion mutations in Central and Eastern Europe reimbursement, diagnostic procedures, and treatment availability. true false /api/journal/10037472 REVIEWED true false 10037472 true 10037472 true 1753-6561 Journal FOREIGN 18 Suppl. 3 2 2 2024 Lung cancer remains the leading cause of cancer-related deaths in Europe, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. NSCLC is a heterogeneous disease encompassing various oncogenic alterations. Among them, EGFR exon 20 insertion mutations, constituting 0.3-2.2% of NSCLC cases, rank as the third most common EGFR alteration after exon 19 deletions and the L858R point mutation in exon 21, also known as "typical" EGFR alterations. Recent advancements in understanding the molecular pathogenesis of NSCLC have led to significant breakthroughs in targeted therapies, revolutionizing treatment options for patients with specific genetic alterations.This article presents the outcomes of a Virtual Meeting conducted on the online platform (provided Within3©) from September 19 to October 30, 2022. The meeting focused on addressing the challenges in the diagnosis and treatment of NSCLC patients with EGFR exon 20 insertion mutations. The participants consisted of healthcare professionals from ten Central and Eastern European countries who shared their experiences and opinions on various aspects, including epidemiology, treatment options, and diagnostic approaches employed in their respective healthcare institutions. The discussions were facilitated through open-ended and multiple-choice questions.The primary objective of this article is to provide an overview of the identified challenges associated with the diagnosis and treatment of this heterogeneous disease, based on the assessments of the meeting participants. Among the major emerging challenges discussed, the reimbursement issues concerning next-generation sequencing (NGS), a recommended method in NSCLC molecular diagnosis, and the availability of approved targeted treatments to enhance patient outcomes were of paramount importance. Furthermore, fostering community awareness of lung cancer and promoting harmonized lung cancer care were identified as areas deserving greater attention. Notably, the rapidly evolving treatment landscape, particularly with NGS for NSCLC patients with genomic alterations like EGFR, ALK, RET, MET, NTRK, and ROS1, necessitates prioritizing the development of new drugs, even for the relatively smaller subgroup with exon 20 insertion mutations. true 2024 true true true true true false GOLD 2026-01-04 false http://www.biomedcentral.com/bmcproc 0 0 0 0 0 0 0 0 0 0 0 0 0 0 false false false false 2024-05-19T10:02:48.243+0000 0 8 0 12 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 114826753 /api/authorship/114826753 1 0.083333336 true false false Hochmair Maximilian J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826754 /api/authorship/114826754 2 0.083333336 false false false Unk Mojca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826755 /api/authorship/114826755 3 0.083333336 false false false Spasic Jelena true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826756 /api/authorship/114826756 4 0.083333336 false false false Cerić Timur true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826757 /api/authorship/114826757 5 0.083333336 false false false Konsoulova Assia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826758 /api/authorship/114826758 6 0.083333336 false false false Dediu Mircea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826759 /api/authorship/114826759 7 0.083333336 false false false Bogos Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826760 /api/authorship/114826760 8 0.083333336 false false false Hegmane Alinta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826761 /api/authorship/114826761 9 0.083333336 false false false Oselin Kersti true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826762 /api/authorship/114826762 10 0.083333336 false false false Stojiljkovic Marko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826763 /api/authorship/114826763 11 0.083333336 false false false Roblek Tina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114826764 /api/authorship/114826764 12 0.083333336 false true false Jakopovic Marko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25605020 /api/publicationidentifier/25605020 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 10.1186/s12919-023-00287-6 https://doi.org/10.1186/s12919-023-00287-6 false true PublicationIdentifier 25605019 /api/publicationidentifier/25605019 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true 38233854 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38233854&dopt=Abstract false true Keyword 1199878 /api/keyword/1199878 true 1199878 true Keyword 1532190 /api/keyword/1532190 true true Keyword 2540121 /api/keyword/2540121 true true Keyword 3325711 /api/keyword/3325711 true true Keyword 3325712 /api/keyword/3325712 true true Keyword 3325713 /api/keyword/3325713 true true /api/publication/34630550 <div class="JournalArticle Publication long-list"> <div class="authors"> <div class="autype autype0"> <span class="author-name" >Hochmair Maximilian J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Unk Mojca </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spasic Jelena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cerić Timur </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Konsoulova Assia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dediu Mircea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bogos Krisztina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hegmane Alinta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oselin Kersti </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stojiljkovic Marko </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roblek Tina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jakopovic Marko </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34630550" target="_blank">Unmet needs in EGFR exon 20 insertion mutations in Central and Eastern Europe : reimbursement, diagnostic procedures, and treatment availability..</a></div> <div> <span class="journal-title">BMC PROCEEDINGS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1753-6561">1753-6561</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">Suppl. 3</span> <span class="page"> Paper 2. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1186/s12919-023-00287-6" target="_blank" href="https://doi.org/10.1186/s12919-023-00287-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="38233854" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38233854&dopt=Abstract"> PubMed </a> </span> </span> <div class="mtid"><span class="long-pub-mtid">Publication: 34630550</span> | <span class="status-data status-APPROVED"> Published </span> | <span class="type-subtype">Journal Article ( Conference paper in journal ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2024.03.19. 13:28 Éva Pécsi (MTMT Közp 2,3, admin) </div> </div></div>