https://m2.mtmt.hu/ hun 2026-09-20 21:08 JournalArticle 34596897 VALIDATED true National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary Department of Neurology, Semmelweis University, Budapest, Hungary Department of Neurology, University of New Mexico, Albuquerque, NM, United States Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary Cited By :17 Export Date: 25 February 2025 Correspondence Address: Kamondi, A.; National Institute of Mental Health, Hungary; email: kamondianita@gmail.com 0 false 2026-09-16T09:04:15.059+0000 2026-09-16T07:33:54.308+0000 2024-02-16T09:05:09.740+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-09-15T13:50:56.196+0000 2026-09-16T07:33:54.671+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Kamondi, Anita Epilepsy and epileptiform activity in late-onset Alzheimer disease clinical and pathophysiological advances, gaps and conundrums true true /api/journal/10011746 REVIEWED true false 10011746 false 10011746 true 1759-4758 1759-4766 Journal FOREIGN 20 3 162 182 162 21 2024 A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in AD by years, and its presence has been shown to predict a faster disease course. In animal models of AD, amyloid and tau pathology are linked to cortical network hyperexcitability that precedes the first signs of memory decline. Thus, detection of epileptiform activity in AD has substantial clinical importance as a potential novel modifiable risk factor for dementia. In this Review, we summarize the epidemiological evidence for the complex bidirectional relationship between AD and epilepsy, examine the effect of epileptiform activity and seizures on cognition in people with AD, and discuss the precision medicine treatment strategies based on the latest research in human and animal models. Finally, we outline some of the unresolved questions of the field that should be addressed by rigorous research, including whether particular clinicopathological subtypes of AD have a stronger association with epilepsy, and the sequence of events between epileptiform activity and amyloid and tau pathology. Funding 2037669 /api/funding/2037669 false true Funding 2037670 /api/funding/2037670 false true Funding 2037671 /api/funding/2037671 false true Funding 2037672 /api/funding/2037672 false true true 2024 true true true false true false NONE 2026-09-16 false 76 0 74 68 7 74 75 63 70 72 72 66 66 70 6 0 76 70 74 68 0 11 11 Folyóiratcikk Journal Article 24 67 Könyvrészlet Chapter in Book 25 6 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 10 10 10 10 2025 0 38 36 38 36 2026 0 28 24 28 24 D1 false 10000108 false false false 2024-02-29T10:20:26.034+0000 Amerikai úti Ideggyógyászati és Idegsebészeti I... (OMIII); Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Neurológiai Klinika (SE / AOK / K) 2 26 3 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 114554834 /api/authorship/114554834 1 0.2 true false true Author 10000108 /api/author/10000108 Kamondi Anita true 10000108 true Kamondi Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114554835 /api/authorship/114554835 2 0.2 false false false Grigg-Damberger Madeleine true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114554836 /api/authorship/114554836 3 0.2 false false false Löscher Wolfgang true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114554837 /api/authorship/114554837 4 0.2 false false false Tanila Heikki true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114554838 /api/authorship/114554838 5 0.2 false true false Author 10055054 /api/author/10055054 Horváth András Attila true 10055054 true Horvath Andras Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25533277 /api/publicationidentifier/25533277 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1038/s41582-024-00932-4 https://doi.org/10.1038/s41582-024-00932-4 false true PublicationIdentifier 25813230 /api/publicationidentifier/25813230 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001162171300001 https://www.webofscience.com/wos/woscc/full-record/001162171300001 false true PublicationIdentifier 25747664 /api/publicationidentifier/25747664 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85185149031 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185149031 false true PublicationIdentifier 25533276 /api/publicationidentifier/25533276 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38356056 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38356056&dopt=Abstract false true SjrRating 11487059 /api/sjrrating/11487059 4 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 true 2728 true D1 DIRECT true true /api/publication/34596897 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000108"><a href="/gui2/?type=authors&mode=browse&sel=10000108" target="_blank">Kamondi Anita ✉ (<span class="authorship-author-name">Kamondi Anita</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Amerikai úti Ideggyógyászati és Idegsebészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grigg-Damberger Madeleine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Löscher Wolfgang </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tanila Heikki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055054"><a href="/gui2/?type=authors&mode=browse&sel=10055054" target="_blank">Horvath Andras Attila (<span class="authorship-author-name">Horváth András Attila</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Amerikai úti Ideggyógyászati és Idegsebészeti Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34596897" target="_blank">Epilepsy and epileptiform activity in late-onset Alzheimer disease : clinical and pathophysiological advances, gaps and conundrums.</a></div> <div> <span class="journal-title">NATURE REVIEWS NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1759-4758">1759-4758</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1759-4766">1759-4766</a>)</span>: <span class="journal-volume">20</span> <span class="journal-issue">3</span> <span class="page"> pp 162-182 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41582-024-00932-4" target="_blank" href="https://doi.org/10.1038/s41582-024-00932-4"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001162171300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001162171300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85185149031" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185149031"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38356056" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38356056&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 76</span> | Független: 70 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 63 | Scopus jelölt:&nbsp;70 | WoS/Scopus jelölt:&nbsp;72 | DOI jelölt:&nbsp;75 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34596897&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34596897</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Brain Research Program(NAP2022-I-9/2022), (PD-132652) Támogató: NKFI, (bo_78_20_2020) Támogató: Bolyai János Kutatási Ösztöndíj, (2019-2.1.7-ERA-NET-2020-00006) Támogató: NKFI </div> <div class="lastModified">Utolsó módosítás: 2026.09.16. 09:33 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary Department of Neurology, Semmelweis University, Budapest, Hungary Department of Neurology, University of New Mexico, Albuquerque, NM, United States Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germ...</pre> </div></div>