https://m2.mtmt.hu/ eng 2026-05-01 07:06 JournalArticle 34578220 APPROVED true 0 false 2026-02-06T19:10:27.227+0000 2025-04-03T12:03:35.979+0000 2024-02-13T16:30:30.549+0000 true 521 Szuper Admin /api/admin/521 Admin true 2026-04-08T13:18:18.823+0000 2026-04-08T13:18:18.823+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-15T11:48:46.697+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ruska, Yvette GLP-1 Receptor Signaling Has Different Effects on the Perikarya and Axons of the Hypophysiotropic Thyrotropin-Releasing Hormone Synthesizing Neurons in Male Mice true true /api/journal/4276 REVIEWED true false 4276 false 4276 true 1050-7256 1557-9077 Journal FOREIGN 34 2 252 260 252 9 2024 Background: Glucagon-like peptide 1 (GLP-1) is involved in the regulation of energy and glucose homeostasis. As GLP-1 has similar effects on the energy homeostasis as the hypophysiotropic thyrotropin-releasing hormone (TRH) neurons that regulate the hypothalamic-pituitary-thyroid (HPT) axis, we raised the possibility that the TRH neurons are involved in the mediation of the effects of GLP-1. Therefore, the relationship and interaction of the GLP-1 system and the TRH neurons of the hypothalamic paraventricular nucleus (PVN) were studied.Methods: To examine the anatomical and functional relationship of TRH neurons and the GLP-1 system in the PVN, immunocytochemistry, in situ hybridization, in vitro patch-clamp electrophysiology, metabolic phenotyping, and explant experiments were performed.Results: Our data demonstrate that the TRH neurons of the PVN are innervated by GLP-1 producing neurons and express the GLP-1 receptor (GLP-1R). However, not only do the GLP-1-innervated TRH neurons express GLP-1R but the receptor is also present in the axons of the hypophysiotropic TRH neurons in the blood-brain barrier free median eminence (ME) suggesting that peripherally derived GLP-1 may also influence the TRH neurons. In vitro, GLP-1 increased the firing rate of TRH neurons and depolarized them. In addition, GLP-1 directly stimulated the GABAergic input of a population of TRH neurons. Furthermore, GLP-1 inhibited the release of TRH from the hypophysiotropic axons in the ME. In vivo, peripheral GLP-1R agonist administration markedly inhibited the food intake and the energy expenditure, but had no effect on the TRH expression in the PVN and resulted in lower circulating free T4 levels.Conclusions: Our results indicate that GLP-1R activation has a direct stimulatory effect on TRH neurons in the PVN, but the activation of GLP-1R may also inhibit TRH neurons by facilitating their inhibitory inputs or by inhibiting the axon terminals of these cells in the ME. The innervation of TRH neurons by GLP-1 neurons suggests that TRH neurons might be influenced by both circulating GLP-1 and by GLP-1 neurons of the nucleus tractus solitarii. The lack of GLP-1R agonist-induced regulation of TRH neurons in vivo suggests that the HPT axis does not mediate the GLP-1R agonist-induced weight loss. Funding 2045801 /api/funding/2045801 false true Funding 2037314 /api/funding/2037314 false true Funding 2045802 /api/funding/2045802 false true Funding 2038189 /api/funding/2038189 false true true 2024 true true true false true false RESTRICTED 2026-02-06 false 5 0 5 4 1 5 5 5 3 5 5 4 4 4 1 0 5 4 5 4 0 10 10 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 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true Keyword 173 /api/keyword/173 true 173 true Keyword 1517 /api/keyword/1517 true 1517 true Keyword 1065938 /api/keyword/1065938 true 1065938 true Keyword 1070014 /api/keyword/1070014 true 1070014 true Keyword 1519164 /api/keyword/1519164 true true SjrRating 11462083 /api/sjrrating/11462083 13 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true D1 DIRECT true true /api/publication/34578220 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10076858"><a href="/gui2/?type=authors&mode=browse&sel=10076858" target="_blank">Ruska Yvette (<span class="authorship-author-name">Szilágyi Yvette Magdolna</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032670"><a href="/gui2/?type=authors&mode=browse&sel=10032670" target="_blank">Peterfi Zoltan (<span class="authorship-author-name">Péterfi Zoltán Attila</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055055"><a href="/gui2/?type=authors&mode=browse&sel=10055055" target="_blank">Szilvasy-Szabo Anett (<span class="authorship-author-name">Stiftné Szilvásy-Szabó Anett</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053106"><a href="/gui2/?type=authors&mode=browse&sel=10053106" target="_blank">Kovari Dora (<span class="authorship-author-name">Kővári Dóra</span> <span class="authorAux-mtmt"> neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky Erik (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084248"><a href="/gui2/?type=authors&mode=browse&sel=10084248" target="_blank">Doroghazi Beata (<span class="authorship-author-name">Dorogházi Beáta Vanessza</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben Balazs (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024706"><a href="/gui2/?type=authors&mode=browse&sel=10024706" target="_blank">Toth Blanka (<span class="authorship-author-name">Tóth Blanka</span> <span class="authorAux-mtmt"> analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Chemical Technology and Biotechnology">FCTB</span>/Department of Inorganic and Analytical Chemistry; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matziari Magdalini </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="136"><a href="/gui2/?type=authors&mode=browse&sel=136" target="_blank">Wittmann Gabor (<span class="authorship-author-name">Wittmann Gábor</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba ✉ (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34578220" target="_blank">GLP-1 Receptor Signaling Has Different Effects on the Perikarya and Axons of the Hypophysiotropic Thyrotropin-Releasing Hormone Synthesizing Neurons in Male Mice</a></div> <div> <span class="journal-title">THYROID</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1050-7256">1050-7256</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-9077">1557-9077</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">2</span> <span class="page"> pp 252-260 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1089/thy.2023.0284" target="_blank" href="https://doi.org/10.1089/thy.2023.0284"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001150713700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001150713700001"> WoS </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:blue" title="191246" target="_blank" href="http://real.mtak.hu/191246"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85184076909" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184076909"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38062754" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38062754&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 4 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34578220&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34578220</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> Recovery and Resilience Facility of the European Union within the framework of Programme Szécheny...(RRF-2.3.1-21-2022-00011), National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), (RRF-2.3.1-21-2022-00011), Hungarian Academy of Sciences(NAP3.0) </div> <div class="lastModified">Last Modified: 2025.04.03. 14:03 Márta Turek (KOKI admin 4) </div> <div class="lockedBy">Centrally managed 2025.05.15. 13:48 Andrea Vándor (VA, admin) </div> </div></div>