Genetic Factors Associated with the Development of Neuropathy in Type 2 Diabetes.

https://m2.mtmt.hu/ eng 2026-06-29 00:59 JournalArticle 34574277 VALIDATED true 0 false 2026-05-28T11:46:58.611+0000 2025-05-07T05:16:37.672+0000 2024-02-12T13:38:03.346+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Márta Molnár-Taga (SE 4-es admin) true 10062250 2026-05-28T11:38:49.629+0000 2026-05-28T11:38:49.629+0000 2025-05-07T05:16:37.891+0000 true 10099440 Csernyik Rita /api/admin/10099440 Admin Rita Csernyik (MTMT központi admin) true Admin 10099440 /api/admin/10099440 Rita Csernyik (MTMT központi admin) Csernyik Rita true true 2025-04-25T06:19:56.289+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Tordai, Dóra Zsuszanna Genetic Factors Associated with the Development of Neuropathy in Type 2 Diabetes. true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 3 1815 1815 15 2024 Neuropathy is a serious and frequent complication of type 2 diabetes (T2DM). This study was carried out to search for genetic factors associated with the development of diabetic neuropathy by whole exome sequencing. For this study, 24 patients with long-term type 2 diabetes with neuropathy and 24 without underwent detailed neurological assessment and whole exome sequencing. Cardiovascular autonomic function was evaluated by cardiovascular reflex tests. Heart rate variability was measured by the triangle index. Sensory nerve function was estimated by Neurometer and Medoc devices. Neuropathic symptoms were characterized by the neuropathy total symptom score (NTSS). Whole exome sequencing (WES) was performed on a Thermo Ion GeneStudio S5 system determining the coding sequences of approximately 32,000 genes comprising 50 million base pairs. Variants were detected by Ion Reporter software and annotated using ANNOVAR, integrating database information from dbSNP, ClinVar, gnomAD, and OMIM. Integrative genomics viewer (IGV) was used for visualization of the mapped reads. We have identified genetic variants that were significantly associated with increased (22-49-fold) risk of neuropathy (rs2032930 and rs2032931 of recQ-mediated genome instability protein 2 (RMI2) gene), rs604349 of myosin binding protein H like (MYBPHL) gene and with reduced (0.07-0.08-fold) risk (rs917778 of multivesicular body subunit 12B (MVB12B) and rs2234753 of retinoic acid X receptor alpha (RXRA) genes). The rs2032930 showed a significant correlation with current perception thresholds measured at 5 Hz and 250 Hz for n. medianus (p = 0.042 and p = 0.003, respectively) and at 5 Hz for n. peroneus (p = 0.037), as well as the deep breath test (p = 0.022) and the NTSS (p = 0.023). The rs2032931 was associated with current perception thresholds (p = 0.003 and p = 0.037, respectively), deep breath test (p = 0.022), and NTSS (p = 0.023). The rs604349 correlated with values measured at 2000 (p = 0.049), 250 (p = 0.018), and 5 Hz (p = 0.005) for n. medianus, as well as warm perception threshold measured by Medoc device (p = 0.042). The rs2234753 showed correlations with a current perception threshold measured at 2000 Hz for n. medianus (p = 0.020), deep breath test (p = 0.040), and NTSS (p = 0.003). There was a significant relationship between rs91778 and cold perception threshold (p = 0.013). In our study, genetic variants have been identified that may have an impact on the risk of neuropathy developing in type 2 diabetic patients. These results could open up new opportunities for early preventive measures and might provide targets for new drug developments in the future. Funding 2037143 /api/funding/2037143 (2020-4.1.1.-TKP2020-MOLOKRIV) false true Funding 2037144 /api/funding/2037144 (SE-ELKH ENDOMOLPAT) false true true true 2024 true true true false true false GOLD 2026-05-28 true https://doi.org/10.3390/ijms25031815 8 0 8 6 2 8 7 7 7 8 8 6 6 6 2 0 8 6 8 6 0 4 4 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 5 4 5 4 D1 false 10012016 false false false 2024-02-11T13:38:09.214+0000 Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Belgyógyászati és Onkológiai Klinika (SE / AOK / K); ELKH-SE Endokrin Molekuláris Patológiai Kutatóc... (SE / AOK / K / BOK) 16 20 3 17 0 true 10099440 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 114369902 /api/authorship/114369902 Tordai, Dóra Zsuszanna ✉ [Tordai, Dóra Zsuzsanna (Belgyógyászat), author] Department of Internal Medicine and Oncology (SU / FM / C) 1 0.059 true false true Author 10080509 /api/author/10080509 Dóra Zsuzsanna Tordai (Belgyógyászat) Tordai Dóra Zsuzsanna true true Tordai Dóra Zsuszanna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369903 /api/authorship/114369903 Hajdú, Noémi [Hajdú, Noémi (Belgyógyászat), author] Department of Internal Medicine and Oncology (SU / FM / C) 2 0.059 false false false Author 10069757 /api/author/10069757 Noémi Hajdú (Belgyógyászat) Hajdú Noémi true true Hajdú Noémi true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369904 /api/authorship/114369904 Rácz, Ramóna [Rácz, Ramóna (Belgyógyászat), author] Department of Internal Medicine and Oncology (SU / FM / C) 3 0.059 false false false Author 10090364 /api/author/10090364 Ramóna Rácz (Belgyógyászat) Rácz Ramóna true true Rácz Ramóna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369905 /api/authorship/114369905 Istenes, Ildikó [Istenes, Ildikó (Belgyógyászat), author] Department of Internal Medicine and Oncology (SU / FM / C) 4 0.059 false false false Author 10024010 /api/author/10024010 Ildikó Istenes (Belgyógyászat) Istenes Ildikó true 10024010 true Istenes Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369906 /api/authorship/114369906 Békeffy, Magdolna [Békeffy, Magdolna Zsófia (belgyógyászat), author] Department of Internal Medicine and Oncology (SU / FM / C) 5 0.059 false false false Author 10074321 /api/author/10074321 Magdolna Zsófia Békeffy (belgyógyászat) Békeffy Magdolna Zsófia true true Békeffy Magdolna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369907 /api/authorship/114369907 Vági, Orsolya Erzsébet [Vági, Orsolya (Belgyógyászat), author] Department of Internal Medicine and Oncology (SU / FM / C) 6 0.059 false false false Author 10054195 /api/author/10054195 Orsolya Vági (Belgyógyászat) Vági Orsolya true 10054195 true Vági Orsolya Erzsébet true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369908 /api/authorship/114369908 Kempler, Miklós [Kempler, Miklós (orvos), author] Belgyógyászati és Hematológiai Klinika (SU / FM / C) 7 0.059 false false false Author 10067837 /api/author/10067837 Miklós Kempler (orvos) Kempler Miklós true true Kempler Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369909 /api/authorship/114369909 Körei, Anna Erzsébet [Körei, Anna Erzsébet (Orvostudomány), author] Department of Internal Medicine and Oncology (SU / FM / C) 8 0.059 false false false Author 10035653 /api/author/10035653 Anna Erzsébet Körei (Orvostudomány) Körei Anna Erzsébet true 10035653 true Körei Anna Erzsébet true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369910 /api/authorship/114369910 Tóbiás, Bálint [Tóbiás, Bálint (molekuláris bioló...), author] Department of Internal Medicine and Oncology (SU / FM / C); ELKH-SE-ENDOMOLPAT (SU / FM / C / DIMO) 9 0.059 false false false Author 10024698 /api/author/10024698 Bálint Tóbiás (molekuláris biológia, endokrinológia) Tóbiás Bálint true 10024698 true Tóbiás Bálint true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369911 /api/authorship/114369911 Illés, Anett [Illés, Anett (Molekuláris bioló...), author] Department of Internal Medicine and Oncology (SU / FM / C) 10 0.059 false false false Author 10048349 /api/author/10048349 Anett Illés (Molekuláris biológia, Genetika) Illés Anett true 10048349 true Illés Anett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369912 /api/authorship/114369912 Pikó, Henriett [Pikó, Henriett (molekuláris biológia), author] Department of Internal Medicine and Oncology (SU / FM / C); ELKH-SE-ENDOMOLPAT (SU / FM / C / DIMO) 11 0.059 false false false Author 10050709 /api/author/10050709 Henriett Pikó (molekuláris biológia) Pikó Henriett true 10050709 true Pikó Henriett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369913 /api/authorship/114369913 Kósa, János Pál [Kósa, János (molekuláris biológia), author] Department of Internal Medicine and Oncology (SU / FM / C); ELKH-SE-ENDOMOLPAT (SU / FM / C / DIMO) 12 0.059 false false false Author 10024099 /api/author/10024099 János Kósa (molekuláris biológia) Kósa János true 10024099 true Kósa János Pál true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369914 /api/authorship/114369914 Árvai, Kristóf [Árvai, Kristóf (molekuláris biológia), author] 13 0.059 false false false Author 10053042 /api/author/10053042 Kristóf Árvai (molekuláris biológia) Árvai Kristóf true 10053042 true Árvai Kristóf true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369915 /api/authorship/114369915 Papp, Márton 14 0.05882353 false false false Papp Márton true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369916 /api/authorship/114369916 Lakatos, Péter András [Lakatos, Péter (Osteológia, endok...), author] Department of Internal Medicine and Oncology (SU / FM / C); ELKH-SE-ENDOMOLPAT (SU / FM / C / DIMO) 15 0.059 false false false Author 10012016 /api/author/10012016 Péter Lakatos (Osteológia, endokrinológia, molekuláris biológia) Lakatos Péter true 10012016 true Lakatos Péter András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369917 /api/authorship/114369917 Kempler, Péter [Kempler, Péter (Belgyógyászat, di...), author] Department of Internal Medicine and Oncology (SU / FM / C) 16 0.059 false false false Author 10024012 /api/author/10024012 Péter Kempler (Belgyógyászat, diabetológia) Kempler Péter true 10024012 true Kempler Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 114369918 /api/authorship/114369918 Putz, Zsuzsanna [Putz, Zsuzsanna (Belgyógyászat, di...), author] Department of Internal Medicine and Oncology (SU / FM / C); ELKH-SE-ENDOMOLPAT (SU / FM / C / DIMO) 17 0.059 false true false Author 10013989 /api/author/10013989 Zsuzsanna Putz (Belgyógyászat, diabetológia, klinikofarmakológia) Putz Zsuzsanna true 10013989 true Putz Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25464002 /api/publicationidentifier/25464002 DOI: 10.3390/ijms25031815 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25031815 https://doi.org/10.3390/ijms25031815 false true PublicationIdentifier 25626522 /api/publicationidentifier/25626522 WoS: 001160210900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001160210900001 https://www.webofscience.com/wos/woscc/full-record/001160210900001 true true PublicationIdentifier 29429890 /api/publicationidentifier/29429890 REAL: 219555 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GOLD true 219555 http://real.mtak.hu/219555 false true PublicationIdentifier 25626518 /api/publicationidentifier/25626518 Scopus: 85184696753 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85184696753 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184696753 true true PublicationIdentifier 25464003 /api/publicationidentifier/25464003 PubMed: 38339094 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38339094 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38339094&dopt=Abstract false true Classification 12324 /api/classification/12324 General and internal medicine true true Classification 12215 /api/classification/12215 Clinical medicine true true Classification 10582 /api/classification/10582 Molecular biology true true Keyword 1044596 /api/keyword/1044596 Type 2 diabetes true 1044596 true Keyword 1084176 /api/keyword/1084176 Genetic variants true 1084176 true Keyword 3293958 /api/keyword/3293958 neuropathy risk true true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true /api/publication/34574277 Tordai Dóra Zsuszanna et al. Genetic Factors Associated with the Development of Neuropathy in Type 2 Diabetes.. (2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 3<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <a href="/gui2/?type=authors&mode=browse&sel=10080509" target="_blank">Tordai Dóra Zsuszanna ✉ (Tordai Dóra Zsuzsanna Belgyógyászat) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10069757" target="_blank">Hajdú Noémi (Hajdú Noémi Belgyógyászat) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10090364" target="_blank">Rácz Ramóna (Rácz Ramóna Belgyógyászat) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10024010" target="_blank">Istenes Ildikó (Istenes Ildikó Belgyógyászat) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10074321" target="_blank">Békeffy Magdolna (Békeffy Magdolna Zsófia belgyógyászat) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10054195" target="_blank">Vági Orsolya Erzsébet (Vági Orsolya Belgyógyászat) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10067837" target="_blank">Kempler Miklós (Kempler Miklós orvos) </a> SU/FM/C/Belgyógyászati és Hematológiai Klinika ;    <a href="/gui2/?type=authors&mode=browse&sel=10035653" target="_blank">Körei Anna Erzsébet (Körei Anna Erzsébet Orvostudomány) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10024698" target="_blank">Tóbiás Bálint (Tóbiás Bálint molekuláris biológia, endokrinológia) </a> SU/FM/C/Department of Internal Medicine and Oncology; SU/FM/C/DIMO/ELKH-SE-ENDOMOLPAT ;    <a href="/gui2/?type=authors&mode=browse&sel=10048349" target="_blank">Illés Anett (Illés Anett Molekuláris biológia, Genetika) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10050709" target="_blank">Pikó Henriett (Pikó Henriett molekuláris biológia) </a> SU/FM/C/Department of Internal Medicine and Oncology; SU/FM/C/DIMO/ELKH-SE-ENDOMOLPAT ;    <a href="/gui2/?type=authors&mode=browse&sel=10024099" target="_blank">Kósa János Pál (Kósa János molekuláris biológia) </a> SU/FM/C/Department of Internal Medicine and Oncology; SU/FM/C/DIMO/ELKH-SE-ENDOMOLPAT ;    <a href="/gui2/?type=authors&mode=browse&sel=10053042" target="_blank">Árvai Kristóf (Árvai Kristóf molekuláris biológia) </a> ;    Papp Márton ;    <a href="/gui2/?type=authors&mode=browse&sel=10012016" target="_blank">Lakatos Péter András (Lakatos Péter Osteológia, endokrinológia, molekuláris biológia) </a> SU/FM/C/Department of Internal Medicine and Oncology; SU/FM/C/DIMO/ELKH-SE-ENDOMOLPAT ;    <a href="/gui2/?type=authors&mode=browse&sel=10024012" target="_blank">Kempler Péter (Kempler Péter Belgyógyászat, diabetológia) </a> SU/FM/C/Department of Internal Medicine and Oncology ;    <a href="/gui2/?type=authors&mode=browse&sel=10013989" target="_blank">Putz Zsuzsanna (Putz Zsuzsanna Belgyógyászat, diabetológia, klinikofarmakológia) </a> SU/FM/C/Department of Internal Medicine and Oncology; SU/FM/C/DIMO/ELKH-SE-ENDOMOLPAT </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34574277" target="_blank">Genetic Factors Associated with the Development of Neuropathy in Type 2 Diabetes.</a></div> <div> INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>): 25 3 Paper 1815. 15 p. (2024) </div> <div class="pub-footer"> Language: English | <a style="color:blue" title="10.3390/ijms25031815" target="_blank" href="https://doi.org/10.3390/ijms25031815"> DOI </a> <a style="color:blue" title="001160210900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001160210900001"> WoS </a> <a style="color:black" title="219555" target="_blank" href="http://real.mtak.hu/219555"> REAL </a> <a style="color:blue" title="85184696753" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184696753"> Scopus </a> <a style="color:blue" title="38339094" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38339094&dopt=Abstract"> PubMed </a> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> Citing papers: 8 | Independent citation: 6 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus: 7 | WoS/Scopus assigned: 8 | Number of citations with DOI: 7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34574277&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid">Publication: 34574277 | Validated Core Citing | Journal Article ( Article ) | Scientific | kézi felvitel </div> <div class="funder"> (2020-4.1.1.-TKP2020-MOLOKRIV), (SE-ELKH ENDOMOLPAT) </div> <div class="lastModified">Last Modified: 2025.05.07. 07:16 Rita Csernyik (MTMT központi admin) </div> <div class="lockedBy">Centrally managed 2025.04.25. 08:19 Rita Csernyik (MTMT központi admin) </div> </div></div>