https://m2.mtmt.hu/ hun 2026-05-30 10:56 JournalArticle 34563187 VALIDATED true Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, H-1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, H-1083, Hungary Doctoral School, Semmelweis University, Budapest, H-1085, Hungary Maternity Private Clinic of Obstetrics and Gynecology, Budapest, H-1126, Hungary Department of Surgery, Medical School, University of Pécs, Pécs, H-7624, Hungary Department of Obstetrics and Gynecology, Medical School, University of Debrecen, Debrecen, H-4032, Hungary Doctoral School of Biology, ELTE Eötvös Loránd University, Budapest, H-1117, Hungary Department of Pharmacology and Pharmacotherapy, Medical School, University of Debrecen, Debrecen, H-4032, Hungary Faculty of Health and Sport Sciences, Széchenyi István University, Győr, H-9026, Hungary Department of Pharmacology, Monash Biomedicine Discovery Institute, Clayton, 3168, Australia Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women’s Hospital, Parkville, 3052, Australia Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Be’er Sheva, 8410501, Israel Department of Obstetrics and Gynecology, Medical School, Wayne State University, Detroit, 48201, MI, United States Department of Obstetrics and Gynecology, Medical School, Semmelweis University, 27 Baross Street, Budapest, H-1088, Hungary Export Date: 09 January 2025; Cited By: 1; Correspondence Address: N.G. Than; Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Magyar Tudósok Körútja 2, H-1117, Hungary; email: than.gabor@semmelweis.hu 0 false 2026-05-23T13:28:19.316+0000 2024-11-28T06:10:30.246+0000 2024-02-07T08:40:55.120+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin Szabó Regina (ELTE TTK admin 5) true 2026-02-06T07:38:33.863+0000 2026-02-06T07:38:33.863+0000 2024-11-28T06:10:30.692+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2025-05-07T09:27:20.072+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Tóth, Eszter true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 3 1865 1865 23 2024 Miscarriages affect 50–70% of all conceptions and 15–20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1–5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pathophysiology of RPL is incomplete, and thus, reliable diagnostic/preventive tools are not yet available. Here, we aimed to define the diagnostic value of three placental proteins for RPL: human chorionic gonadotropin free beta-subunit (free-β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF). Blood samples were collected from women with RPL (n = 14) and controls undergoing elective termination of pregnancy (n = 30) at the time of surgery. Maternal serum protein concentrations were measured by BRAHMS KRYPTOR Analyzer. Daily multiple of median (dMoM) values were calculated for gestational age-specific normalization. To obtain classifiers, logistic regression analysis was performed, and ROC curves were calculated. There were differences in changes of maternal serum protein concentrations with advancing healthy gestation. Between 6 and 13 weeks, women with RPL had lower concentrations and dMoMs of free β-hCG, PAPP-A, and PlGF than controls. PAPP-A dMoM had the best discriminative properties (AUC = 0.880). Between 9 and 13 weeks, discriminative properties of all protein dMoMs were excellent (free β-hCG: AUC = 0.975; PAPP-A: AUC = 0.998; PlGF: AUC = 0.924). In conclusion, free-β-hCG and PAPP-A are valuable biomarkers for RPL, especially between 9 and 13 weeks. Their decreased concentrations indicate the deterioration of placental functions, while lower PlGF levels indicate problems with placental angiogenesis after 9 weeks. Funding 2036939 /api/funding/2036939 (LP2014-7/2014,) false true Funding 2036940 /api/funding/2036940 (Premium_2019-436) Támogató: Premium Post-Doctoral Fellowship of the Hungarian Academy of Sciences false true Funding 2036941 /api/funding/2036941 (HUN-REN SA-83/2021) Támogató: HUN_REN false true Funding 2036942 /api/funding/2036942 (FIEK-16-1-2016-0005) false true Funding 2036943 /api/funding/2036943 (K124862) false true Funding 2036944 /api/funding/2036944 (K128262) false true Funding 2036945 /api/funding/2036945 Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2036946 /api/funding/2036946 (2019-2.1.7-ERANET-2020-00014) false true Funding 2036947 /api/funding/2036947 ERA PerMed(2020-346 grant) Támogató: EU false true true 2024 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms25031865 13 0 13 12 1 13 13 10 7 10 10 9 9 12 1 0 13 12 13 12 0 17 17 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 10 9 10 9 2026 0 2 2 2 2 D1 false 10012513,10019319 false false false 2024-02-07T09:50:04.772+0000 Biológia Doktori Iskola (ELTE / TTK); Doktori Iskola (SE); Egészség- és Sporttudományi Kar (SZE); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Molekuláris Élettudományi Intézet (HRN TTK); Sebészeti Klinika (PTE / ÁOK); Szülészeti és Nőgyógyászati Intézet (DE / ÁOK); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Szülészeti és Nőgyógyászati Tanszék (SZE / ESK) 15 76 11 18 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 114287856 /api/authorship/114287856 Tóth, Eszter [Tóth, Eszter (Proteomika), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Molekuláris Élettudományi Intézet (HRN TTK) 1 0.056 true false false Author 10025667 /api/author/10025667 Tóth Eszter (Proteomika) Tóth Eszter true 10025667 true Tóth Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287857 /api/authorship/114287857 Györffy, Dániel [Györffy, Dániel (Bioinformatika), szerző] Információs Technológiai és Bionikai Kar (PPKE); Molekuláris Élettudományi Intézet (HRN TTK) 2 0.056 false false false Author 10019484 /api/author/10019484 Györffy Dániel (Bioinformatika) Györffy Dániel true 10019484 true Györffy Dániel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287858 /api/authorship/114287858 Posta, Máté [Posta, Máté (Szülészet- és nőg...), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Doktori Iskola (SE); Molekuláris Élettudományi Intézet (HRN TTK) 3 0.056 false false false Author 10082656 /api/author/10082656 Posta Máté (Szülészet- és nőgyógyászat) Posta Máté true true Posta Máté true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287859 /api/authorship/114287859 Hupuczi, Petronella [Hupuczi, Petronella (Aneszteziológia é...), szerző] 4 0.056 false false false Author 10012513 /api/author/10012513 Hupuczi Petronella (Aneszteziológia és intenzív terápia) Hupuczi Petronella true 10012513 true Hupuczi Petronella true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287860 /api/authorship/114287860 Balogh, Andrea [Balogh, Andrea (Immunológia), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Molekuláris Élettudományi Intézet (HRN TTK) 5 0.056 false false false Author 10019319 /api/author/10019319 Balogh Andrea (Immunológia) Balogh Andrea true 10019319 true Balogh Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287861 /api/authorship/114287861 Szalai, Gábor [Szalai, Gábor (Radiológia), szerző] Sebészeti Klinika (PTE / ÁOK) 6 0.055555556 false false false Author 10025710 /api/author/10025710 Szalai Gábor (Radiológia) Szalai Gábor true 10025710 true Szalai Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287862 /api/authorship/114287862 Orosz, Gergő [Orosz, Gergő Balázs (Szülészet Nőgyógy...), szerző] Szülészeti és Nőgyógyászati Intézet (DE / ÁOK) 7 0.056 false false false Author 10059724 /api/author/10059724 Orosz Gergő Balázs (Szülészet Nőgyógyászat) Orosz Gergő Balázs true 10059724 true Orosz Gergő true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287863 /api/authorship/114287863 Orosz, László [Orosz, László (Szülészet-nőgyógy...), szerző] Szülészeti és Nőgyógyászati Intézet (DE / ÁOK) 8 0.056 false false false Author 10032549 /api/author/10032549 Orosz László (Szülészet-nőgyógyászat) Orosz László true 10032549 true Orosz László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287864 /api/authorship/114287864 Szilágyi, András [Szilágyi, András (Bioinformatika), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI) 9 0.056 false false false Author 10010376 /api/author/10010376 Szilágyi András (Bioinformatika) Szilágyi András true 10010376 true Szilágyi András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287865 /api/authorship/114287865 Oravecz, Orsolya [Oravecz, Orsolya (biológia, immunol...), szerző] Biológia Doktori Iskola (ELTE / TTK) 10 0.056 false false false Author 10081331 /api/author/10081331 Oravecz Orsolya (biológia, immunológia, molekuláris biológia, mikrobiológia) Oravecz Orsolya true true Oravecz Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287866 /api/authorship/114287866 Veress, Lajos 11 0.055555556 false false false Veress Lajos true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287867 /api/authorship/114287867 Nagy, Sándor [Nagy, Sándor (szülészet-nőgyógy...), szerző] Egészség- és Sporttudományi Kar (SZE); Szülészeti és Nőgyógyászati Tanszék (SZE / ESK) 12 0.056 false false false Author 10034624 /api/author/10034624 Nagy Sándor (szülészet-nőgyógyászat) Nagy Sándor true 10034624 true Nagy Sándor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287868 /api/authorship/114287868 Török, Olga [Török, Olga (szülészet-nőgyógy...), szerző] Szülészeti és Nőgyógyászati Intézet (DE / ÁOK) 13 0.056 false false false Author 10039073 /api/author/10039073 Török Olga (szülészet-nőgyógyászat, klinikai genetika) Török Olga true 10039073 true Török Olga true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287869 /api/authorship/114287869 Murthi, Padma 14 0.055555556 false false false Murthi Padma true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287870 /api/authorship/114287870 Erez, Offer 15 0.055555556 false false false Erez Offer true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287871 /api/authorship/114287871 Papp, Zoltán [Papp, Zoltán (Szülészet-nőgyógy...), szerző] Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 16 0.056 false false false Author 1373182 /api/author/1373182 Papp Zoltán (Szülészet-nőgyógyászat, klinikai genetika) Papp Zoltán true 1373182 true Papp Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287872 /api/authorship/114287872 Ács, Nándor [Ács, Nándor (Szülészet-nőgyógy...), szerző] Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK) 17 0.056 false false false Author 10013998 /api/author/10013998 Ács Nándor (Szülészet-nőgyógyászat) Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114287873 /api/authorship/114287873 Than, Nándor Gábor ✉ [Than, Nándor Gábor (Rendszerbiológia), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK); Molekuláris Élettudományi Intézet (HRN TTK) 18 0.056 false true true Author 10011696 /api/author/10011696 Than Nándor Gábor (Rendszerbiológia) Than Nándor Gábor true 10011696 true Than Nándor Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 25436504 /api/publicationidentifier/25436504 DOI: 10.3390/ijms25031865 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25031865 https://doi.org/10.3390/ijms25031865 false true PublicationIdentifier 31711333 /api/publicationidentifier/31711333 PPKE Publikáció: 3579 SwordSource 10035 /api/publicationsource/10035 PPKE Publikáció PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true PPKE Publikáció PPCE Publications https://publikacio.ppke.hu/id/eprint/@@@ true true true GREEN true 3579 https://publikacio.ppke.hu/id/eprint/3579 false true PublicationIdentifier 25718426 /api/publicationidentifier/25718426 WoS: 001160453700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001160453700001 https://www.webofscience.com/wos/woscc/full-record/001160453700001 false true PublicationIdentifier 25605710 /api/publicationidentifier/25605710 Scopus: 85184714647 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85184714647 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184714647 false true PublicationIdentifier 25463787 /api/publicationidentifier/25463787 PubMed: 38339143 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38339143 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38339143&dopt=Abstract false true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 49826268 /api/reference/49826268 1. Dugas, C., and Slane, V.H. (2020). StatPearls, StatPearls Publishing LLC. 1 false true Reference 49826269 /api/reference/49826269 2. WHO (1977). Recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended 14 October 1976. Acta Obstet. Gynecol. Scand., 56, 247–253., DOI: 10.3109/00016347709162009 2 10.3109/00016347709162009 false true Reference 49826270 /api/reference/49826270 3. Galindo 2012: A systematic review to calculate background miscarriage rates using life table analysis., Birth Defects Res. Part A Clin. Mol. Teratol., 94, p. 417, DOI: 10.1002/bdra.23014 3 10.1002/bdra.23014 false true Reference 49826271 /api/reference/49826271 4. Larsen, E.C., Christiansen, O.B., Kolte, A.M., and Macklon, N. (2013). New insights into mechanisms behind miscarriage. BMC Med., 11., DOI: 10.1186/1741-7015-11-154 4 10.1186/1741-7015-11-154 false true Reference 49826272 /api/reference/49826272 5. Savitz 2002: Epidemiologic measures of the course and outcome of pregnancy., Epidemiol. Rev., 24, p. 91, DOI: 10.1093/epirev/mxf006 5 10.1093/epirev/mxf006 false true Reference 49826273 /api/reference/49826273 6. Ford 2009: Recurrent pregnancy loss: Etiology, diagnosis, and therapy., Rev. Obstet. Gynecol., 2, p. 76 6 false true Reference 49826274 /api/reference/49826274 7. Zinaman 1996: Estimates of human fertility and pregnancy loss., Fertil. Steril., 65, p. 503, DOI: 10.1016/S0015-0282(16)58144-8 7 10.1016/S0015-0282(16)58144-8 false true Reference 49826275 /api/reference/49826275 8. Ellish 1996: A prospective study of early pregnancy loss., Hum. Reprod., 11, p. 406, DOI: 10.1093/HUMREP/11.2.406 8 10.1093/HUMREP/11.2.406 false true Reference 49826276 /api/reference/49826276 9. Wilcox 1988: Incidence of Early Loss of Pregnancy., N. Engl. J. Med., 319, p. 189, DOI: 10.1056/NEJM198807283190401 9 10.1056/NEJM198807283190401 false true Reference 49826277 /api/reference/49826277 10. Rai 2006: Recurrent miscarriage., Lancet, 368, p. 601, DOI: 10.1016/S0140-6736(06)69204-0 10 10.1016/S0140-6736(06)69204-0 false true Reference 49826278 /api/reference/49826278 11. Chard 1991: 11 Frequency of implantation and early pregnancy loss in natural cycles., Baillière’s Clin. Obstet. Gynaecol., 5, p. 179, DOI: 10.1016/S0950-3552(05)80077-X 11 10.1016/S0950-3552(05)80077-X false true Reference 49826279 /api/reference/49826279 12. Macklon 2002: Conception to ongoing pregnancy: The ‘black box’ of early pregnancy loss., Hum. Reprod. Update, 8, p. 333, DOI: 10.1093/humupd/8.4.333 12 10.1093/humupd/8.4.333 false true Reference 49826280 /api/reference/49826280 13. Brezina 2014: Classic and cutting-edge strategies for the management of early pregnancy loss., Obstet. Gynecol. Clin. N. Am., 41, p. 1, DOI: 10.1016/j.ogc.2013.10.011 13 10.1016/j.ogc.2013.10.011 false true Reference 49826281 /api/reference/49826281 14. Regan 1989: Influence of past reproductive performance on risk of spontaneous abortion., Br. Med. J., 299, p. 541, DOI: 10.1136/bmj.299.6698.541 14 10.1136/bmj.299.6698.541 false true Reference 49826282 /api/reference/49826282 15. Knudsen 1991: Prognosis of a new pregnancy following previous spontaneous abortions., Eur. J. Obstet. Gynecol. Reprod. Biol., 39, p. 31, DOI: 10.1016/0028-2243(91)90138-B 15 10.1016/0028-2243(91)90138-B false true Reference 49826283 /api/reference/49826283 16. Risch 1988: Risk factors for spontaneous abortion and its recurrence., Am. J. Epidemiol., 128, p. 420, DOI: 10.1093/oxfordjournals.aje.a114982 16 10.1093/oxfordjournals.aje.a114982 false true Reference 49826284 /api/reference/49826284 17. Clifford 1994: An informative protocol for the investigation of recurrent miscarriage: Preliminary experience of 500 consecutive cases., Hum. Reprod., 9, p. 1328, DOI: 10.1093/oxfordjournals.humrep.a138703 17 10.1093/oxfordjournals.humrep.a138703 false true Reference 49826285 /api/reference/49826285 18. Stirrat 1990: Recurrent miscarriage., Lancet, 336, p. 673, DOI: 10.1016/0140-6736(90)92159-F 18 10.1016/0140-6736(90)92159-F false true Reference 49826286 /api/reference/49826286 19. Li 2002: Recurrent miscarriage: Aetiology, management and prognosis., Hum. Reprod. Update, 8, p. 463, DOI: 10.1093/humupd/8.5.463 19 10.1093/humupd/8.5.463 false true Reference 49826287 /api/reference/49826287 20. Vaiman 2015: Genetic regulation of recurrent spontaneous abortion in humans., Biomed. J., 38, p. 11, DOI: 10.4103/2319-4170.133777 20 10.4103/2319-4170.133777 false true Reference 49826288 /api/reference/49826288 21. ACOG (2002). ACOG practice bulletin. Management of recurrent pregnancy loss. Number 24, February 2001. (Replaces Technical Bulletin Number 212, September 1995). American College of Obstetricians and Gynecologists. Int. J. Gynecol. Obstet., 78, 179–190., DOI: 10.1016/S0020-7292(02)00197-2 21 10.1016/S0020-7292(02)00197-2 false true Reference 49826289 /api/reference/49826289 22. American Society for Reproductive Medicine (ASRM) (2012). Evaluation and treatment of recurrent pregnancy loss: A committee opinion. Fertil. Steril., 98, 1103–1111., DOI: 10.1016/j.fertnstert.2012.06.048 22 10.1016/j.fertnstert.2012.06.048 false true Reference 49826290 /api/reference/49826290 23. 2011: The psychological and social consequences of miscarriage., Expert Rev. Obstet. Gynecol., 6, p. 295, DOI: 10.1586/eog.11.14 23 10.1586/eog.11.14 false true Reference 49826291 /api/reference/49826291 24. Murphy 2017: The psychological, social, and economic impact of stillbirth on families., Semin. Fetal Neonatal Med., 22, p. 129, DOI: 10.1016/j.siny.2017.02.002 24 10.1016/j.siny.2017.02.002 false true Reference 49826292 /api/reference/49826292 25. Giorlandino 1998: Spermatozoa with chromosomal abnormalities may result in a higher rate of recurrent abortion., Fertil. Steril., 70, p. 576, DOI: 10.1016/S0015-0282(98)00192-7 25 10.1016/S0015-0282(98)00192-7 false true Reference 49826293 /api/reference/49826293 26. Rubio 2003: Chromosomal abnormalities and embryo development in recurrent miscarriage couples., Hum. Reprod., 18, p. 182, DOI: 10.1093/humrep/deg015 26 10.1093/humrep/deg015 false true Reference 49826294 /api/reference/49826294 27. Stirrat 1990: Recurrent miscarriage II: Clinical associations, causes, and management., Lancet, 336, p. 728, DOI: 10.1016/0140-6736(90)92215-4 27 10.1016/0140-6736(90)92215-4 false true Reference 49826295 /api/reference/49826295 28. Tulppala 1993: A prospective study of 63 couples with a history of recurrent spontaneous abortion: Contributing factors and outcome of subsequent pregnancies., Hum. Reprod., 8, p. 764, DOI: 10.1093/oxfordjournals.humrep.a138137 28 10.1093/oxfordjournals.humrep.a138137 false true Reference 49826296 /api/reference/49826296 29. Uehara 2001: Preferential X-chromosome inactivation in women with idiopathic recurrent pregnancy loss., Fertil. Steril., 76, p. 908, DOI: 10.1016/S0015-0282(01)02845-X 29 10.1016/S0015-0282(01)02845-X false true Reference 49826297 /api/reference/49826297 30. Aldrich 2001: HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage., Mol. Hum. Reprod., 7, p. 1167, DOI: 10.1093/molehr/7.12.1167 30 10.1093/molehr/7.12.1167 false true Reference 49826298 /api/reference/49826298 31. Hirahara 1998: Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials., Fertil. Steril., 70, p. 246, DOI: 10.1016/S0015-0282(98)00164-2 31 10.1016/S0015-0282(98)00164-2 false true Reference 49826299 /api/reference/49826299 32. Garzia 2004: Lack of expression of endometrial prolactin in early implantation failure: A pilot study., Hum. Reprod., 19, p. 1911, DOI: 10.1093/humrep/deh350 32 10.1093/humrep/deh350 false true Reference 49826300 /api/reference/49826300 33. Craig 2002: Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss., Fertil. Steril., 78, p. 487, DOI: 10.1016/S0015-0282(02)03247-8 33 10.1016/S0015-0282(02)03247-8 false true Reference 49826301 /api/reference/49826301 34. Li 2000: Endocrinological and endometrial factors in recurrent miscarriage., Br. J. Obstet. Gynaecol., 107, p. 1471, DOI: 10.1111/j.1471-0528.2000.tb11670.x 34 10.1111/j.1471-0528.2000.tb11670.x false true Reference 49826302 /api/reference/49826302 35. Bussen 1999: Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion., Hum. Reprod., 14, p. 18, DOI: 10.1093/humrep/14.1.18 35 10.1093/humrep/14.1.18 false true Reference 49826303 /api/reference/49826303 36. Grimbizis 2001: Clinical implications of uterine malformations and hysteroscopic treatment results., Hum. Reprod. Update, 7, p. 161, DOI: 10.1093/humupd/7.2.161 36 10.1093/humupd/7.2.161 false true Reference 49826304 /api/reference/49826304 37. Salim 2003: A comparative study of the morphology of congenital uterine anomalies in women with and without a history of recurrent first trimester miscarriage., Hum. Reprod., 18, p. 162, DOI: 10.1093/humrep/deg030 37 10.1093/humrep/deg030 false true Reference 49826305 /api/reference/49826305 38. Homer 2000: The septate uterus: A review of management and reproductive outcome., Fertil. Steril., 73, p. 1, DOI: 10.1016/S0015-0282(99)00480-X 38 10.1016/S0015-0282(99)00480-X false true Reference 49826306 /api/reference/49826306 39. Clifford 1999: Endometrial CD56+ natural killer cells in women with recurrent miscarriage: A histomorphometric study., Hum. Reprod., 14, p. 2727, DOI: 10.1093/humrep/14.11.2727 39 10.1093/humrep/14.11.2727 false true Reference 49826307 /api/reference/49826307 40. Quenby 1999: Pre-implantation endometrial leukocytes in women with recurrent miscarriage., Hum. Reprod., 14, p. 2386, DOI: 10.1093/humrep/14.9.2386 40 10.1093/humrep/14.9.2386 false true Reference 49826308 /api/reference/49826308 41. Lachapelle 1996: Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome., J. Immunol., 156, p. 4027, DOI: 10.4049/jimmunol.156.10.4027 41 10.4049/jimmunol.156.10.4027 false true Reference 49826309 /api/reference/49826309 42. Eblen 2000: Alterations in humoral immune responses associated with recurrent pregnancy loss., Fertil. Steril., 73, p. 305, DOI: 10.1016/S0015-0282(99)00505-1 42 10.1016/S0015-0282(99)00505-1 false true Reference 49826310 /api/reference/49826310 43. Wilson 2001: Abnormal immunoglobulin subclass patterns in women with a history of recurrent miscarriage., Fertil. Steril., 76, p. 915, DOI: 10.1016/S0015-0282(01)02857-6 43 10.1016/S0015-0282(01)02857-6 false true Reference 49826311 /api/reference/49826311 44. Makhseed 2001: Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions., Hum. Reprod., 16, p. 2219, DOI: 10.1093/humrep/16.10.2219 44 10.1093/humrep/16.10.2219 false true Reference 49826312 /api/reference/49826312 45. Quack 2001: Leukocyte activation in the decidua of chromosomally normal and abnormal fetuses from women with recurrent abortion., Hum. Reprod., 16, p. 949, DOI: 10.1093/humrep/16.5.949 45 10.1093/humrep/16.5.949 false true Reference 49826313 /api/reference/49826313 46. Kovalevsky 2004: Evaluation of the Association Between Hereditary Thrombophilias and Recurrent Pregnancy Loss: A Meta-analysis., Arch. Intern. Med., 164, p. 558, DOI: 10.1001/archinte.164.5.558 46 10.1001/archinte.164.5.558 false true Reference 49826314 /api/reference/49826314 47. Rey 2003: Thrombophilic disorders and fetal loss: A meta-analysis., Lancet, 361, p. 901, DOI: 10.1016/S0140-6736(03)12771-7 47 10.1016/S0140-6736(03)12771-7 false true Reference 49826315 /api/reference/49826315 48. Rai 2002: Factor V Leiden and recurrent miscarriage—Prospective outcome of untreated pregnancies., Hum. Reprod., 17, p. 442, DOI: 10.1093/humrep/17.2.442 48 10.1093/humrep/17.2.442 false true Reference 49826316 /api/reference/49826316 49. Rai 2001: Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage., Hum. Reprod., 16, p. 961, DOI: 10.1093/humrep/16.5.961 49 10.1093/humrep/16.5.961 false true Reference 49826317 /api/reference/49826317 50. Rai 1995: High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies., Hum. Reprod., 10, p. 3301, DOI: 10.1093/oxfordjournals.humrep.a135907 50 10.1093/oxfordjournals.humrep.a135907 false true Reference 49826318 /api/reference/49826318 51. Rai 1995: Immunology: Antiphospholipid antibodies and β2-glycoprotein-I in 500 women with recurrent miscarriage: Results of a comprehensive screening approach., Hum. Reprod., 10, p. 2001, DOI: 10.1093/oxfordjournals.humrep.a136224 51 10.1093/oxfordjournals.humrep.a136224 false true Reference 49826319 /api/reference/49826319 52. Greaves 2000: Guidelines on the Investigation and Management of the Antiphospholipid Syndrome., Br. J. Haematol., 109, p. 704, DOI: 10.1046/j.1365-2141.2000.02069.x 52 10.1046/j.1365-2141.2000.02069.x false true Reference 49826320 /api/reference/49826320 53. Christiansen 2008: Multifactorial Etiology of Recurrent Miscarriage and Its Scientific and Clinical Implications., Gynecol. Obstet. Investig., 66, p. 257, DOI: 10.1159/000149575 53 10.1159/000149575 false true Reference 49826321 /api/reference/49826321 54. Trout 2000: Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?., Fertil. Steril., 74, p. 335, DOI: 10.1016/S0015-0282(00)00625-7 54 10.1016/S0015-0282(00)00625-7 false true Reference 49826322 /api/reference/49826322 55. Yalti 2004: High basal estradiol level and FSH/LH ratio in unexplained recurrent pregnancy loss., Arch. Gynecol. Obstet., 270, p. 37 55 false true Reference 49826323 /api/reference/49826323 56. Pils, S., Promberger, R., Springer, S., Joura, E., and Ott, J. (2016). Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis. PLoS ONE, 11., DOI: 10.1371/journal.pone.0161606 56 10.1371/journal.pone.0161606 false true Reference 49826324 /api/reference/49826324 57. Okon 1998: Serum Androgen Levels in Women who Have Recurrent Miscarriages and their Correlation with Markers of Endometrial Function., Fertil. Steril., 69, p. 682, DOI: 10.1016/S0015-0282(98)00007-7 57 10.1016/S0015-0282(98)00007-7 false true Reference 49826325 /api/reference/49826325 58. Kim 2011: ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients., Mol. BioSystems, 7, p. 1430, DOI: 10.1039/c0mb00219d 58 10.1039/c0mb00219d false true Reference 49826326 /api/reference/49826326 59. Ogasawara 1997: Are serum progesterone levels predictive of recurrent miscarriage in future pregnancies?., Fertil. Steril., 68, p. 806, DOI: 10.1016/S0015-0282(97)00328-2 59 10.1016/S0015-0282(97)00328-2 false true Reference 49826327 /api/reference/49826327 60. Wu 2017: Serum biomarker analysis in patients with recurrent spontaneous abortion., Mol. Med. Rep., 16, p. 2367, DOI: 10.3892/mmr.2017.6890 60 10.3892/mmr.2017.6890 false true Reference 49826328 /api/reference/49826328 61. Cui 2019: iTRAQ and PRM-based quantitative proteomics in early recurrent spontaneous abortion: Biomarkers discovery., Clin. Proteom., 16, p. 36, DOI: 10.1186/s12014-019-9256-y 61 10.1186/s12014-019-9256-y false true Reference 49826329 /api/reference/49826329 62. Ledger 2003: Measurement of inhibin A and inhibin pro-alphaC in early human pregnancy and their role in the prediction of pregnancy outcome in patients with recurrent pregnancy loss., Fertil. Steril., 80, p. 1473, DOI: 10.1016/S0015-0282(03)02215-5 62 10.1016/S0015-0282(03)02215-5 false true Reference 49826330 /api/reference/49826330 63. Liu 2016: Predictive value of serum β-hCG for early pregnancy outcomes among women with recurrent spontaneous abortion., Int. J. Gynecol. Obstet., 135, p. 16, DOI: 10.1016/j.ijgo.2016.03.007 63 10.1016/j.ijgo.2016.03.007 false true Reference 49826331 /api/reference/49826331 64. Muttukrishna 2002: Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages., Hum. Reprod., 17, p. 3072, DOI: 10.1093/humrep/17.12.3072 64 10.1093/humrep/17.12.3072 false true Reference 49826332 /api/reference/49826332 65. Rull 2005: Expression of β-subunit of HCG genes during normal and failed pregnancy., Hum. Reprod., 20, p. 3360, DOI: 10.1093/humrep/dei261 65 10.1093/humrep/dei261 false true Reference 49826333 /api/reference/49826333 66. Darwish, A., Ghorab, N., El-Ashmawy, M.H., Kamal, M.M., and Soliman, M.S.A. (2005). Biochemical Markers for Prediction of Pregnancy Outcome in Cases of Recurrent Pregnancy Loss, Middle East Fertility Society. 66 false true Reference 49826334 /api/reference/49826334 67. Heinig 2007: Maternal serum free ß-hCG and PAPP-A in patients with habitual abortion-influence on first-trimester screening for chromosomal abnormalities., Prenat. Diagn., 27, p. 814, DOI: 10.1002/pd.1779 67 10.1002/pd.1779 false true Reference 49826335 /api/reference/49826335 68. Kato 2002: Human chorionic gonadotropin exhibits normal biological activity in patients with recurrent pregnancy loss., Gynecol. Endocrinol., 16, p. 179, DOI: 10.1080/gye.16.3.179.186 68 10.1080/gye.16.3.179.186 false true Reference 49826336 /api/reference/49826336 69. Prakash 2005: Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage., Fertil. Steril., 83, p. 1758, DOI: 10.1016/j.fertnstert.2004.11.072 69 10.1016/j.fertnstert.2004.11.072 false true Reference 49826337 /api/reference/49826337 70. Bao 2013: Increased Dickkopf-1 expression in patients with unexplained recurrent spontaneous miscarriage., Clin. Exp. Immunol., 172, p. 437, DOI: 10.1111/cei.12066 70 10.1111/cei.12066 false true Reference 49826338 /api/reference/49826338 71. Rull 2013: Increased placental expression and maternal serum levels of apoptosis-inducing TRAIL in recurrent miscarriage., Placenta, 34, p. 141, DOI: 10.1016/j.placenta.2012.11.032 71 10.1016/j.placenta.2012.11.032 false true Reference 49826339 /api/reference/49826339 72. Pang, L., Wei, Z., Li, O., Huang, R., Qin, J., Chen, H., Fan, X., and Chen, Z.J. (2013). An increase in vascular endothelial growth factor (VEGF) and VEGF soluble receptor-1 (sFlt-1) are associated with early recurrent spontaneous abortion. PLoS ONE, 8., DOI: 10.1371/journal.pone.0075759 72 10.1371/journal.pone.0075759 false true Reference 49826340 /api/reference/49826340 73. Laird 2001: Leptin and leptin-binding activity in women with recurrent miscarriage: Correlation with pregnancy outcome., Hum. Reprod., 16, p. 2008, DOI: 10.1093/humrep/16.9.2008 73 10.1093/humrep/16.9.2008 false true Reference 49826341 /api/reference/49826341 74. Hassan 2014: Soluble fms-like tyrosine kinase-1 and vascular endothelial growth factor: Novel markers for unexplained early recurrent pregnancy loss., Asian Pac. J. Reprod., 3, p. 30, DOI: 10.1016/S2305-0500(13)60181-5 74 10.1016/S2305-0500(13)60181-5 false true Reference 49826342 /api/reference/49826342 75. Christiansen 2005: Evidence-based investigations and treatments of recurrent pregnancy loss., Fertil. Steril., 83, p. 821, DOI: 10.1016/j.fertnstert.2004.12.018 75 10.1016/j.fertnstert.2004.12.018 false true Reference 49826343 /api/reference/49826343 76. Christiansen 2006: Evidence-based investigations and treatments of recurrent pregnancy loss., Curr. Opin. Obstet. Gynecol., 18, p. 304, DOI: 10.1097/01.gco.0000193011.73405.07 76 10.1097/01.gco.0000193011.73405.07 false true Reference 49826344 /api/reference/49826344 77. Burton 2004: Placental Oxidative Stress: From Miscarriage to Preeclampsia., J. Soc. Gynecol. Investig., 11, p. 342, DOI: 10.1016/j.jsgi.2004.03.003 77 10.1016/j.jsgi.2004.03.003 false true Reference 49826345 /api/reference/49826345 78. Lyu 2013: Transcriptional profiling with a pathway-oriented analysis in the placental villi of unexplained miscarriage., Placenta, 34, p. 133, DOI: 10.1016/j.placenta.2012.12.003 78 10.1016/j.placenta.2012.12.003 false true Reference 49826346 /api/reference/49826346 79. Liu 2006: Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss., Biol. Reprod., 75, p. 414, DOI: 10.1095/biolreprod.105.049379 79 10.1095/biolreprod.105.049379 false true Reference 49826347 /api/reference/49826347 80. Ni, X., Li, X., Guo, Y., Zhou, T., Guo, X., Zhao, C., Lin, M., Zhou, Z., Shen, R., and Guo, X. (2014). Quantitative proteomics analysis of altered protein expression in the placental villous tissue of early pregnancy loss using isobaric tandem mass tags. BioMed Res. Int., 2014., DOI: 10.1155/2014/647143 80 10.1155/2014/647143 false true Reference 49826348 /api/reference/49826348 81. Jauniaux 2005: Pathophysiology of histological changes in early pregnancy loss., Placenta, 26, p. 114, DOI: 10.1016/j.placenta.2004.05.011 81 10.1016/j.placenta.2004.05.011 false true Reference 49826349 /api/reference/49826349 82. Jeschke 2010: Glycoprotein and carbohydrate binding protein expression in the placenta in early pregnancy loss., J. Reprod. Immunol., 85, p. 99, DOI: 10.1016/j.jri.2009.10.012 82 10.1016/j.jri.2009.10.012 false true Reference 49826350 /api/reference/49826350 83. Gupta 2007: The Role of Oxidative Stress in Spontaneous Abortion and Recurrent Pregnancy Loss: A Systematic Review., Obstet. Gynecol. Surv., 62, p. 335, DOI: 10.1097/01.ogx.0000261644.89300.df 83 10.1097/01.ogx.0000261644.89300.df false true Reference 49826351 /api/reference/49826351 84. Su 2004: A gene atlas of the mouse and human protein-encoding transcriptomes., Proc. Natl. Acad. Sci. USA, 101, p. 6062, DOI: 10.1073/pnas.0400782101 84 10.1073/pnas.0400782101 false true Reference 49826352 /api/reference/49826352 85. Szilagyi, A., Gelencser, Z., Romero, R., Xu, Y., Kiraly, P., Demeter, A., Palhalmi, J., Gyorffy, B.A., Juhasz, K., and Hupuczi, P. (2020). Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia. Int. J. Mol. Sci., 21., DOI: 10.3390/ijms21020628 85 10.3390/ijms21020628 false true Reference 49826353 /api/reference/49826353 86. Than 2018: Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia., Front. Immunol., 9, p. 1661, DOI: 10.3389/fimmu.2018.01661 86 10.3389/fimmu.2018.01661 false true Reference 49826354 /api/reference/49826354 87. Wright 2010: First-trimester combined screening for trisomy 21 at 7-14 weeks’ gestation., Ultrasound Obstet. Gynecol., 36, p. 404, DOI: 10.1002/uog.7755 87 10.1002/uog.7755 false true Reference 49826355 /api/reference/49826355 88. Tsiakkas 2015: Serum placental growth factor in the three trimesters of pregnancy: Effects of maternal characteristics and medical history., Ultrasound Obstet. Gynecol., 45, p. 591, DOI: 10.1002/uog.14811 88 10.1002/uog.14811 false true Reference 49826356 /api/reference/49826356 89. Romero 2017: The maternal plasma proteome changes as a function of gestational age in normal pregnancy: A longitudinal study., Am. J. Obstet. Gynecol., 217, p. 67.e1, DOI: 10.1016/j.ajog.2017.02.037 89 10.1016/j.ajog.2017.02.037 false true Reference 49826357 /api/reference/49826357 90. Burton 2015: What is the placenta?., Am. J. Obstet. Gynecol., 213, p. S6.E1, DOI: 10.1016/j.ajog.2015.07.050 90 10.1016/j.ajog.2015.07.050 false true Reference 49826358 /api/reference/49826358 91. Fulop 2022: Clinical aspects of decidualization., Orvosi Hetil., 163, p. 1823 91 false true Reference 49826359 /api/reference/49826359 92. Lakatos 2022: The role of natural killer cells in the immune homeostasis of the maternal fetal interface., Orvosi Hetil., 163, p. 734, DOI: 10.1556/650.2022.32458 92 10.1556/650.2022.32458 false true Reference 49826360 /api/reference/49826360 93. Nagy 2022: The role of platelets in reproduction., Orvosi Hetil., 163, p. 1254, DOI: 10.1556/650.2022.32530 93 10.1556/650.2022.32530 false true Reference 49826361 /api/reference/49826361 94. Huppertz 2008: Placental Origins of Preeclampsia., Hypertension, 51, p. 970, DOI: 10.1161/HYPERTENSIONAHA.107.107607 94 10.1161/HYPERTENSIONAHA.107.107607 false true Reference 49826362 /api/reference/49826362 95. Myatt 2002: Role of placenta in preeclampsia., Endocrine, 19, p. 103, DOI: 10.1385/ENDO:19:1:103 95 10.1385/ENDO:19:1:103 false true Reference 49826363 /api/reference/49826363 96. Roberts 2012: The placenta in preeclampsia., Pregnancy Hypertens., 2, p. 72, DOI: 10.1016/j.preghy.2012.01.001 96 10.1016/j.preghy.2012.01.001 false true Reference 49826364 /api/reference/49826364 97. Redman 2005: Latest Advances in Understanding Preeclampsia., Science, 308, p. 1592, DOI: 10.1126/science.1111726 97 10.1126/science.1111726 false true Reference 49826365 /api/reference/49826365 98. Sitras 2009: Differential Placental Gene Expression in Severe Preeclampsia., Placenta, 30, p. 424, DOI: 10.1016/j.placenta.2009.01.012 98 10.1016/j.placenta.2009.01.012 false true Reference 49826366 /api/reference/49826366 99. Hromadnikova 2012: Extracellular nucleic acids in maternal circulation as potential biomarkers for placental insufficiency., DNA Cell Biol., 31, p. 1221, DOI: 10.1089/dna.2011.1530 99 10.1089/dna.2011.1530 false true Reference 49826367 /api/reference/49826367 100. Ruano, C.S.M., Miralles, F., Mehats, C., and Vaiman, D. (2022). The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases. Antioxidants, 11., DOI: 10.3390/antiox11010106 100 10.3390/antiox11010106 false true Reference 49826368 /api/reference/49826368 101. Pan 2018: Proteomics and bioinformatics analysis of altered protein expression in the placental villous tissue from early recurrent miscarriage patients., Placenta, 61, p. 1, DOI: 10.1016/j.placenta.2017.11.001 101 10.1016/j.placenta.2017.11.001 false true Reference 49826369 /api/reference/49826369 102. Redline 2008: Placental Pathology: A Systematic Approach with Clinical Correlations., Placenta, 29, p. 86, DOI: 10.1016/j.placenta.2007.09.003 102 10.1016/j.placenta.2007.09.003 false true Reference 49826370 /api/reference/49826370 103. Lob 2021: The role of Interleukin-18 in recurrent early pregnancy loss., J. Reprod. Immunol., 148, p. 103432, DOI: 10.1016/j.jri.2021.103432 103 10.1016/j.jri.2021.103432 false true Reference 49826371 /api/reference/49826371 104. Than, G.N., Bohn, H., and Szabo, D.G. (1993). Advances in Pregnancy-Related Protein Research, CRC Press. 104 false true Reference 49826372 /api/reference/49826372 105. (2024, January 24). Human Protein Atlas. Available online: http://www.proteinatlas.org. 105 false true Reference 49826373 /api/reference/49826373 106. Simpson 1981: Endocrine physiology of the placenta., Annu. Rev. Physiol., 43, p. 163, DOI: 10.1146/annurev.ph.43.030181.001115 106 10.1146/annurev.ph.43.030181.001115 false true Reference 49826374 /api/reference/49826374 107. Bohn 1991: Isolation and characterization of membrane-associated placental proteins., Arch. Gynecol. Obstet., 248, p. 191, DOI: 10.1007/BF02390358 107 10.1007/BF02390358 false true Reference 49826375 /api/reference/49826375 108. Bohn 1991: Immunochemically detected placental proteins and their biological functions., Arch. Gynecol. Obstet., 249, p. 107, DOI: 10.1007/BF02391577 108 10.1007/BF02391577 false true Reference 49826376 /api/reference/49826376 109. Malek 2006: C-Reactive Protein Production in Term Human Placental Tissue., Placenta, 27, p. 619, DOI: 10.1016/j.placenta.2005.05.009 109 10.1016/j.placenta.2005.05.009 false true Reference 49826377 /api/reference/49826377 110. Chamley 1997: Synthesis of β2 glycoprotein 1 by the human placenta., Placenta, 18, p. 403, DOI: 10.1016/S0143-4004(97)80040-9 110 10.1016/S0143-4004(97)80040-9 false true Reference 49826378 /api/reference/49826378 111. Duchesne 2007: Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI., Biochem. Biophys. Res. Commun., 359, p. 8, DOI: 10.1016/j.bbrc.2007.05.002 111 10.1016/j.bbrc.2007.05.002 false true Reference 49826379 /api/reference/49826379 112. Jansson 1993: Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation., J. Clin. Endocrinol. Metab., 77, p. 1554 112 false true Reference 49826380 /api/reference/49826380 113. Crowley 2013: Liquid biopsy: Monitoring cancer-genetics in the blood., Nat. Rev. Clin. Oncol., 10, p. 472, DOI: 10.1038/nrclinonc.2013.110 113 10.1038/nrclinonc.2013.110 false true Reference 49826381 /api/reference/49826381 114. Pantel 2013: Circulating Tumor Cells: Liquid Biopsy of Cancer., Clin. Chem., 59, p. 110, DOI: 10.1373/clinchem.2012.194258 114 10.1373/clinchem.2012.194258 false true Reference 49826382 /api/reference/49826382 115. Heitzer 2015: Circulating Tumor DNA as a Liquid Biopsy for Cancer., Clin. Chem., 61, p. 112, DOI: 10.1373/clinchem.2014.222679 115 10.1373/clinchem.2014.222679 false true Reference 49826383 /api/reference/49826383 116. Pantel 2016: Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy., Cancer Discov., 6, p. 479, DOI: 10.1158/2159-8290.CD-15-1483 116 10.1158/2159-8290.CD-15-1483 false true Reference 49826384 /api/reference/49826384 117. Karaszi 2019: Increased placental expression of Placental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?., Placenta, 76, p. 30, DOI: 10.1016/j.placenta.2019.01.011 117 10.1016/j.placenta.2019.01.011 false true Reference 49826385 /api/reference/49826385 118. Than 2014: Placental Protein 13 (PP13)—A Placental Immunoregulatory Galectin Protecting Pregnancy., Front. Immunol., 5, p. 348, DOI: 10.3389/fimmu.2014.00348 118 10.3389/fimmu.2014.00348 false true Reference 49826386 /api/reference/49826386 119. Balogh 2011: Placental protein 13 (PP13/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome., Am. J. Obstet. Gynecol., 205, p. 156.e1, DOI: 10.1016/j.ajog.2011.03.023 119 10.1016/j.ajog.2011.03.023 false true Reference 49826387 /api/reference/49826387 120. Than 2008: Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome., Virchows Arch., 453, p. 387, DOI: 10.1007/s00428-008-0658-x 120 10.1007/s00428-008-0658-x false true Reference 49826388 /api/reference/49826388 121. Than 2015: Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia., J. Pathol. Transl. Med., 49, p. 181, DOI: 10.4132/jptm.2015.02.25 121 10.4132/jptm.2015.02.25 false true Reference 49826389 /api/reference/49826389 122. Romero 2008: First-trimester maternal serum PP13 in the risk assessment for preeclampsia., Am. J. Obstet. Gynecol., 199, p. 122.e1, DOI: 10.1016/j.ajog.2008.01.013 122 10.1016/j.ajog.2008.01.013 false true Reference 49826390 /api/reference/49826390 123. Than, N.G., Romero, R., Meiri, H., Erez, O., Xu, Y., Tarquini, F., Barna, L., Szilagyi, A., Ackerman, R., and Sammar, M. (2011). PP13, maternal ABO blood groups and the risk assessment of pregnancy complications. PLoS ONE, 6., DOI: 10.1371/journal.pone.0021564 123 10.1371/journal.pone.0021564 false true Reference 49826391 /api/reference/49826391 124. Balogh 2019: Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response., Front. Immunol., 10, p. 1240, DOI: 10.3389/fimmu.2019.01240 124 10.3389/fimmu.2019.01240 false true Reference 49826392 /api/reference/49826392 125. Vokalova 2020: Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype., Front. Immunol., 11, p. 145, DOI: 10.3389/fimmu.2020.00145 125 10.3389/fimmu.2020.00145 false true Reference 49826393 /api/reference/49826393 126. Spencer 2008: Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia., Prenat. Diagn., 28, p. 7, DOI: 10.1002/pd.1890 126 10.1002/pd.1890 false true Reference 49826394 /api/reference/49826394 127. Goetzinger 2010: Predicting the risk of pre-eclampsia between 11 and 13 weeks’ gestation by combining maternal characteristics and serum analytes, PAPP-A and free β-hCG., Prenat. Diagn., 30, p. 1138, DOI: 10.1002/pd.2627 127 10.1002/pd.2627 false true Reference 49826395 /api/reference/49826395 128. Mikat 2012: βhCG and PAPP-A in First Trimester: Predictive Factors for Preeclampsia?., Hypertens. Pregnancy, 31, p. 261, DOI: 10.3109/10641955.2011.638956 128 10.3109/10641955.2011.638956 false true Reference 49826396 /api/reference/49826396 129. Spencer 2005: Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free β-hCG and with second-trimester uterine artery Doppler., Prenat. Diagn., 25, p. 949, DOI: 10.1002/pd.1251 129 10.1002/pd.1251 false true Reference 49826397 /api/reference/49826397 130. Basirat 2006: Serum beta human chorionic gonadotropin levels and preeclampsia., Saudi Med. J., 27, p. 1001 130 false true Reference 49826398 /api/reference/49826398 131. Cicero 2003: Integrated ultrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free β-hCG and PAPP-A at 11 to 14 weeks., Prenat. Diagn., 23, p. 306, DOI: 10.1002/pd.588 131 10.1002/pd.588 false true Reference 49826399 /api/reference/49826399 132. Spencer 2000: Screening for trisomy 13 by fetal nuchal translucency and maternal serum free β-hCG and PAPP-A at 10–14 weeks of gestation., Prenat. Diagn., 20, p. 411, DOI: 10.1002/(SICI)1097-0223(200005)20:5&lt;411::AID-PD822&gt;3.0.CO;2-2 132 10.1002/(SICI)1097-0223(200005)20:5&lt;411::AID-PD822&gt;3.0.CO;2-2 false true Reference 49826400 /api/reference/49826400 133. Tul 1999: Screening for trisomy 18 by fetal nuchal translucency and maternal serum free β-hCG and PAPP-A at 10–14 weeks of gestation., Prenat. Diagn., 19, p. 1035, DOI: 10.1002/(SICI)1097-0223(199911)19:11&lt;1035::AID-PD694&gt;3.0.CO;2-2 133 10.1002/(SICI)1097-0223(199911)19:11&lt;1035::AID-PD694&gt;3.0.CO;2-2 false true Reference 49826401 /api/reference/49826401 134. Spencer 2002: A first trimester trisomy 13/trisomy 18 risk algorithm combining fetal nuchal translucency thickness, maternal serum free β-hCG and PAPP-A., Prenat. Diagn., 22, p. 877, DOI: 10.1002/pd.420 134 10.1002/pd.420 false true Reference 49826402 /api/reference/49826402 135. Brizot 1994: Maternal serum pregnancy-associated plasma protein A and fetal nuchal translucency thickness for the prediction of fetal trisomies in early pregnancy., Obstet. Gynecol., 84, p. 918 135 false true Reference 49826403 /api/reference/49826403 136. Zeisler 2016: Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia., N. Engl. J. Med., 374, p. 13, DOI: 10.1056/NEJMoa1414838 136 10.1056/NEJMoa1414838 false true Reference 49826404 /api/reference/49826404 137. Sunderji 2010: Automated assays for sVEGF R1 and PlGF as an aid in the diagnosis of preterm preeclampsia: A prospective clinical study., Am. J. Obstet. Gynecol., 202, p. 40.e1, DOI: 10.1016/j.ajog.2009.07.025 137 10.1016/j.ajog.2009.07.025 false true Reference 49826405 /api/reference/49826405 138. Cowans 2010: First trimester maternal serum placental growth factor in trisomy 21 pregnancies., Prenat. Diagn., 30, p. 449, DOI: 10.1002/pd.2496 138 10.1002/pd.2496 false true Reference 49826406 /api/reference/49826406 139. Stenman 2006: The classification, functions and clinical use of different isoforms of HCG., Hum. Reprod. Update, 12, p. 769, DOI: 10.1093/humupd/dml029 139 10.1093/humupd/dml029 false true Reference 49826407 /api/reference/49826407 140. Carmona 2003: Early hormonal markers of pregnancy outcome after in vitro fertilization and embryo transfer., J. Assist. Reprod. Genet., 20, p. 521, DOI: 10.1023/B:JARG.0000013654.85531.ac 140 10.1023/B:JARG.0000013654.85531.ac false true Reference 49826408 /api/reference/49826408 141. Pillai 2016: Role of serum biomarkers in the prediction of outcome in women with threatened miscarriage: A systematic review and diagnostic accuracy meta-analysis., Hum. Reprod. Update, 22, p. 228 141 false true Reference 49826409 /api/reference/49826409 142. The UniProt Consortium (2018). UniProt: A worldwide hub of protein knowledge. Nucleic Acids Res., 47, D506–D515., DOI: 10.1093/nar/gky1049 142 10.1093/nar/gky1049 false true Reference 49826410 /api/reference/49826410 143. Lawrence 1999: The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A., Proc. Natl. Acad. Sci. USA, 96, p. 3149, DOI: 10.1073/pnas.96.6.3149 143 10.1073/pnas.96.6.3149 false true Reference 49826411 /api/reference/49826411 144. Laursen 2001: Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: Implications for the mechanism of IGFBP-4 proteolysis by PAPP-A., FEBS Lett., 504, p. 36, DOI: 10.1016/S0014-5793(01)02760-0 144 10.1016/S0014-5793(01)02760-0 false true Reference 49826412 /api/reference/49826412 145. Conover 1999: Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A., J. Clin. Endocrinol. Metab., 84, p. 4742, DOI: 10.1210/jcem.84.12.6342 145 10.1210/jcem.84.12.6342 false true Reference 49826413 /api/reference/49826413 146. Prasad 2023: Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System., Fetal Diagn. Ther., 50, p. 236, DOI: 10.1159/000530862 146 10.1159/000530862 false true Reference 49826414 /api/reference/49826414 147. Zhang 2013: A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion., Exp. Ther. Med., 6, p. 485, DOI: 10.3892/etm.2013.1149 147 10.3892/etm.2013.1149 false true Reference 49826415 /api/reference/49826415 148. Rolny 2011: HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF., Cancer Cell, 19, p. 31, DOI: 10.1016/j.ccr.2010.11.009 148 10.1016/j.ccr.2010.11.009 false true Reference 49826416 /api/reference/49826416 149. Lizio, M., Harshbarger, J., Shimoji, H., Severin, J., Kasukawa, T., Sahin, S., Abugessaisa, I., Fukuda, S., Hori, F., and Ishikawa-Kato, S. (2015). Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol., 16., DOI: 10.1186/s13059-014-0560-6 149 10.1186/s13059-014-0560-6 false true Reference 49826417 /api/reference/49826417 150. (2023, December 20). Genotype-Tissue Expression (GTEx) Project. Available online: https://www.gtexportal.org/home/. 150 false true Reference 49826418 /api/reference/49826418 151. Plaisier 2007: Different degrees of vascularization and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues., Fertil. Steril., 88, p. 176, DOI: 10.1016/j.fertnstert.2006.11.102 151 10.1016/j.fertnstert.2006.11.102 false true Reference 49826419 /api/reference/49826419 152. Vailhe 1999: Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion., Hum. Reprod., 14, p. 1628, DOI: 10.1093/humrep/14.6.1628 152 10.1093/humrep/14.6.1628 false true Reference 49826420 /api/reference/49826420 153. Plaisier 2009: Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions., Hum. Reprod., 24, p. 185, DOI: 10.1093/humrep/den296 153 10.1093/humrep/den296 false true Reference 49826421 /api/reference/49826421 154. Dev 2020: Assessment of Maternal Serum Levels of Vascular Endothelial Growth Factor and Placental Growth Factor in Threatened Abortion: A Case Control Study., J. Clin. Diagn. Res., 14, p. 16 154 false true Reference 49826422 /api/reference/49826422 155. Muttukrishna, S., Swer, M., Suri, S., Jamil, A., Calleja-Agius, J., Gangooly, S., Ludlow, H., Jurkovic, D., and Jauniaux, E. (2011). Soluble Flt-1 and PlGF: New markers of early pregnancy loss?. PLoS ONE, 6., DOI: 10.1371/journal.pone.0018041 155 10.1371/journal.pone.0018041 false true Reference 49826423 /api/reference/49826423 156. Andersen 2016: Early pregnancy angiogenic markers and spontaneous abortion: An Odense Child Cohort study., Am. J. Obstet. Gynecol., 215, p. 594.E1, DOI: 10.1016/j.ajog.2016.06.007 156 10.1016/j.ajog.2016.06.007 false true Reference 49826424 /api/reference/49826424 157. Horne 2011: Placental growth factor: A promising diagnostic biomarker for tubal ectopic pregnancy., J. Clin. Endocrinol. Metab., 96, p. E104, DOI: 10.1210/jc.2010-1403 157 10.1210/jc.2010-1403 false true Reference 49826425 /api/reference/49826425 158. Abu-Ghazaleh, N., Brennecke, S., Murthi, P., and Karanam, V. (2023). Association of Vascular Endothelial Growth Factors (VEGFs) with Recurrent Miscarriage: A Systematic Review of the Literature. Int. J. Mol. Sci., 24., DOI: 10.3390/ijms24119449 158 10.3390/ijms24119449 false true Reference 49826426 /api/reference/49826426 159. Vranken 2006: Medians for second-trimester maternal serum markers: Geographical differences and variation caused by median multiples-of-median equations., J. Clin. Pathol., 59, p. 639, DOI: 10.1136/jcp.2005.034272 159 10.1136/jcp.2005.034272 false true Reference 49826427 /api/reference/49826427 160. Levy 1979: Pairwise Comparisons Associated with the K Independent Sample Median Test., Am. Stat., 33, p. 138 160 false true Reference 49826428 /api/reference/49826428 161. Nemenyi, P. (1963). Distribution-Free Multiple Comparisons, Princeton University. 161 false true Reference 49826429 /api/reference/49826429 162. Tukey 1949: Comparing individual means in the analysis of variance., Biometrics, 5, p. 99, DOI: 10.2307/3001913 162 10.2307/3001913 false true Reference 49826430 /api/reference/49826430 163. Kramer 1956: Extension of multiple range tests to group means with unequal numbers of replications., Biometrics, 12, p. 309, DOI: 10.2307/3001469 163 10.2307/3001469 false true Reference 49826431 /api/reference/49826431 164. Richter 2007: Multiple Comparison of Medians Using Permutation Tests., J. Mod. Appl. Stat. Methods, 6, p. 399, DOI: 10.22237/jmasm/1193889900 164 10.22237/jmasm/1193889900 false true Reference 49826432 /api/reference/49826432 165. Cole, L.A. (2010). Biological functions of hCG and hCG-related molecules. Reprod. Biol. Endocrinol., 8., DOI: 10.1186/1477-7827-8-102 165 10.1186/1477-7827-8-102 false true Reference 49826433 /api/reference/49826433 166. Cole 2013: hCG physiology., Placenta, 34, p. 1257, DOI: 10.1016/j.placenta.2013.02.011 166 10.1016/j.placenta.2013.02.011 false true Reference 49826434 /api/reference/49826434 167. Cole 2012: Hyperglycosylated hCG and pregnancy failures., J. Reprod. Immunol., 93, p. 119, DOI: 10.1016/j.jri.2012.01.001 167 10.1016/j.jri.2012.01.001 false true Reference 49826435 /api/reference/49826435 168. Burton 2018: Development of the Human Placenta and Fetal Heart: Synergic or Independent?., Front. Physiol., 9, p. 373, DOI: 10.3389/fphys.2018.00373 168 10.3389/fphys.2018.00373 false true Reference 49826436 /api/reference/49826436 169. Huppertz, B. (2019). Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases. Int. J. Mol. Sci., 21., DOI: 10.3390/ijms21010289 169 10.3390/ijms21010289 false true Reference 49826437 /api/reference/49826437 170. Burton 1999: Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: The Boyd collection revisited., Am. J. Obstet. Gynecol., 181, p. 718, DOI: 10.1016/S0002-9378(99)70518-1 170 10.1016/S0002-9378(99)70518-1 false true Reference 49826438 /api/reference/49826438 171. Chaiworapongsa 2013: Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia., Am. J. Obstet. Gynecol., 208, p. 287.E1, DOI: 10.1016/j.ajog.2013.01.016 171 10.1016/j.ajog.2013.01.016 false true Reference 49826439 /api/reference/49826439 172. Chaiworapongsa 2017: The prediction of fetal death with a simple maternal blood test at 20–24 weeks: A role for angiogenic index-1 (PlGF/sVEGFR-1 ratio)., Am. J. Obstet. Gynecol., 217, p. 682.E1, DOI: 10.1016/j.ajog.2017.10.001 172 10.1016/j.ajog.2017.10.001 false true Reference 49826440 /api/reference/49826440 173. Whitten 2013: Evidence of an imbalance of angiogenic/antiangiogenic factors in massive perivillous fibrin deposition (maternal floor infarction): A placental lesion associated with recurrent miscarriage and fetal death., Am. J. Obstet. Gynecol., 208, p. 310.E1, DOI: 10.1016/j.ajog.2013.01.017 173 10.1016/j.ajog.2013.01.017 false true Reference 49826441 /api/reference/49826441 174. Romero 2011: Placental bed disorders in preterm labor, preterm PROM, spontaneous abortion and abruptio placentae., Best Pract. Res. Clin. Obstet. Gynaecol., 25, p. 313, DOI: 10.1016/j.bpobgyn.2011.02.006 174 10.1016/j.bpobgyn.2011.02.006 false true Reference 49826442 /api/reference/49826442 175. Brosens 2011: The “Great Obstetrical Syndromes” are associated with disorders of deep placentation., Am. J. Obstet. Gynecol., 204, p. 193, DOI: 10.1016/j.ajog.2010.08.009 175 10.1016/j.ajog.2010.08.009 false true Reference 49826443 /api/reference/49826443 176. Boyd 2018: The placenta in intrauterine demise., J. Pathol. Microbiol. Immunol., 126, p. 621 176 false true Reference 49826444 /api/reference/49826444 177. King, J.R., Wilson, M.L., Hetey, S., Kiraly, P., Matsuo, K., Castaneda, A.V., Toth, E., Krenacs, T., Hupuczi, P., and Mhawech-Fauceglia, P. (2019). Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles. Int. J. Mol. Sci., 20., DOI: 10.3390/ijms20204999 177 10.3390/ijms20204999 false true Reference 49826445 /api/reference/49826445 178. Garcia-Sayre, J., Castaneda, A.V., Roman, L.D., and Matsuo, K. (2017). Handbook of Gynecology, Springer. 178 false true Reference 49826446 /api/reference/49826446 179. Reus 2013: Early first-trimester trophoblast volume in pregnancies that result in live birth or miscarriage., Ultrasound Obstet. Gynecol., 42, p. 577, DOI: 10.1002/uog.13197 179 10.1002/uog.13197 false true Reference 49826447 /api/reference/49826447 180. ACOG (2018). Practice Bulletin No. 200: Early Pregnancy Loss. Obstet. Gynecol., 132, e197–e207., DOI: 10.1097/AOG.0000000000002899 180 10.1097/AOG.0000000000002899 false true Reference 49826448 /api/reference/49826448 181. Vomstein, K., Feil, K., Strobel, L., Aulitzky, A., Hofer-Tollinger, S., Kuon, R.J., and Toth, B. (2021). Immunological Risk Factors in Recurrent Pregnancy Loss: Guidelines Versus Current State of the Art. J. Clin. Med., 10., DOI: 10.3390/jcm10040869 181 10.3390/jcm10040869 false true Reference 49826449 /api/reference/49826449 182. Tabacco 2019: Complementemia in pregnancies with antiphospholipid syndrome., Lupus, 28, p. 1503, DOI: 10.1177/0961203319882507 182 10.1177/0961203319882507 false true Reference 49826450 /api/reference/49826450 183. ACOG (2015). The American College of Obstetricians and Gynecologists Practice Bulletin no. 150. Early pregnancy loss. Obstet. Gynecol., 125, 1258–1267., DOI: 10.1097/01.AOG.0000465191.27155.25 183 10.1097/01.AOG.0000465191.27155.25 false true Reference 49826451 /api/reference/49826451 184. Poon 2019: The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention., Int. J. Gynecol. Obstet., 145, p. 1, DOI: 10.1002/ijgo.12802 184 10.1002/ijgo.12802 false true /api/publication/34563187 Tóth Eszter et al. Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value. (2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 3<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025667"><a href="/gui2/?type=authors&mode=browse&sel=10025667" target="_blank">Tóth Eszter (<span class="authorship-author-name">Tóth Eszter</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012513"><a href="/gui2/?type=authors&mode=browse&sel=10012513" target="_blank">Hupuczi Petronella (<span class="authorship-author-name">Hupuczi Petronella</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019319"><a href="/gui2/?type=authors&mode=browse&sel=10019319" target="_blank">Balogh Andrea (<span class="authorship-author-name">Balogh Andrea</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025710"><a href="/gui2/?type=authors&mode=browse&sel=10025710" target="_blank">Szalai Gábor (<span class="authorship-author-name">Szalai Gábor</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Sebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059724"><a href="/gui2/?type=authors&mode=browse&sel=10059724" target="_blank">Orosz Gergő (<span class="authorship-author-name">Orosz Gergő Balázs</span> <span class="authorAux-mtmt"> Szülészet Nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032549"><a href="/gui2/?type=authors&mode=browse&sel=10032549" target="_blank">Orosz László (<span class="authorship-author-name">Orosz László</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081331"><a href="/gui2/?type=authors&mode=browse&sel=10081331" target="_blank">Oravecz Orsolya (<span class="authorship-author-name">Oravecz Orsolya</span> <span class="authorAux-mtmt"> biológia, immunológia, molekuláris biológia, mi...</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Biológia Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Veress Lajos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István Egyetem">SZE</span>/Egészség- és Sporttudományi Kar; <span title="Széchenyi István Egyetem">SZE</span>/<span title="Egészség- és Sporttudományi Kar">ESK</span>/Szülészeti és Nőgyógyászati Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039073"><a href="/gui2/?type=authors&mode=browse&sel=10039073" target="_blank">Török Olga (<span class="authorship-author-name">Török Olga</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murthi Padma </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Erez Offer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34563187" target="_blank">Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">3</span> <span class="page"> Paper 1865. 23 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25031865" target="_blank" href="https://doi.org/10.3390/ijms25031865"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="3579" target="_blank" href="https://publikacio.ppke.hu/id/eprint/3579"> PPKE Publikáció </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001160453700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001160453700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85184714647" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184714647"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38339143" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38339143&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 12 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34563187&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 17 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34563187</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2014-7/2014,), (Premium_2019-436) Támogató: Premium Post-Doctoral Fellowship of the Hungarian Academy of Sciences, (HUN-REN SA-83/2021) Támogató: HUN_REN, (FIEK-16-1-2016-0005), (K124862), (K128262), Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (2019-2.1.7-ERANET-2020-00014), ERA PerMed(2020-346 grant) Támogató: EU </div> <div class="lastModified">Utolsó módosítás: 2024.11.28. 07:10 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:27 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, H-1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, H-1083, Hungary Doctoral School, Semmelweis University, Budapest, H-1085,...</pre> </div></div>