https://m2.mtmt.hu/ hun 2026-09-22 19:46 JournalArticle 34559635 VALIDATED true Cited By :3 Export Date: 11 December 2024 Correspondence Address: Kapuy, O.; Department of Molecular Biology, Hungary; email: kapuy.orsolya@semmelweis.hu Chemicals/CAS: caspase 3, 169592-56-7; caspase 7, 189258-14-8; doublecortin like kinase 1; epigallocatechin gallate, 989-51-5; germinal center kinase; glyceraldehyde 3 phosphate dehydrogenase, 9001-50-7; hydroxymethylglutaryl coenzyme A reductase kinase, 172522-01-9, 72060-32-3; mammalian target of rapamycin complex 1; mammalian target of rapamycin complex 2; n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide, 127243-85-0; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase, 58319-92-9; NIMA related kinase 1; oncogene protein v akt; oncogene protein v raf; polo like kinase 1; resveratrol, 501-36-0; serine threonine protein kinase 3; serine threonine protein kinase ULK1; serine/threonine protein kinase WNK1; sirolimus, 53123-88-9; sulforaphane, 142925-33-5, 4478-93-7; thapsigargin, 67526-95-8; sulfoxide, 120-62-7; Isothiocyanates; sulforaphane; Sulfoxides Tradenames: h 89, Adipogen, Switzerland Manufacturers: Adipogen, Switzerland; Sigma Aldrich; Sigma Aldrich, United States Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, FK-134267 Funding details: National Research, Development and Innovation Office Funding text 1: This work was supported by ÚNKP-22-4-II-SE-21 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development, And Innovation Fund. O.K., M.H. were supported by NKFIH FK-134267 (National Research, Development, and Innovation Office, Hungary). 0 false 2026-09-14T13:15:48.787+0000 2024-02-12T10:48:11.294+0000 2024-02-06T08:41:16.568+0000 true 10057448 Holczer Marianna /api/author/10057448 Author true 10057448 2026-04-23T13:27:01.412+0000 2024-02-12T10:48:11.481+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Holczer, M. The Dual Role of Sulforaphane-Induced Cellular Stress—A Systems Biological Study true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 2 1220 1220 20 2024 The endoplasmic reticulum (ER) plays a crucial role in cellular homeostasis. When ER stress is generated, an autophagic self-digestive process is activated to promote cell survival; however, cell death is induced in the case of excessive levels of ER stress. The aim of the present study was to investigate the effect of a natural compound called sulforaphane (SFN) upon ER stress. Our goal was to investigate how SFN-dependent autophagy activation affects different stages of ER stress induction. We approached our scientific analysis from a systems biological perspective using both theoretical and molecular biological techniques. We found that SFN induced the various cell-death mechanisms in a concentration- and time-dependent manner. The short SFN treatment at low concentrations promoted autophagy, whereas the longer treatment at higher concentrations activated cell death. We proved that SFN activated autophagy in a mTORC1-dependent manner and that the presence of ULK1 was required for its function. A low concentration of SFN pre- or co-treatment combined with short and long ER stress was able to promote cell survival via autophagy induction in each treatment, suggesting the potential medical importance of SFN in ER stress-related diseases. © 2024 by the authors. 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false false 2024-02-11T10:48:11.091+0000 Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 2 7 1 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 114260277 /api/authorship/114260277 1 0.25 true false false Author 10057448 /api/author/10057448 Holczer Marianna true 10057448 true Holczer M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114260278 /api/authorship/114260278 2 0.25 false false false Besze B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114260279 /api/authorship/114260279 3 0.25 false false false Lehel A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114260280 /api/authorship/114260280 4 0.25 false true true Author 10026330 /api/author/10026330 Kapuy Orsolya true 10026330 true Kapuy O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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class="autype autype0"> <span class="author-name" mtid="10057448"><a href="/gui2/?type=authors&mode=browse&sel=10057448" target="_blank">Holczer M. (<span class="authorship-author-name">Holczer Marianna</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Besze B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lehel A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026330"><a href="/gui2/?type=authors&mode=browse&sel=10026330" target="_blank">Kapuy O. ✉ (<span class="authorship-author-name">Kapuy Orsolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34559635" target="_blank">The Dual Role of Sulforaphane-Induced Cellular Stress—A Systems Biological Study</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">2</span> <span class="page"> Paper 1220. 20 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms25021220" target="_blank" href="https://doi.org/10.3390/ijms25021220"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001151547000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001151547000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85183353507" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85183353507"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38279216" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38279216&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 5 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34559635&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34559635</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (ÚNKP-22-4-II-SE-21), (FK-134267) </div> <div class="lastModified">Utolsó módosítás: 2024.02.12. 11:48 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :3 Export Date: 11 December 2024 Correspondence Address: Kapuy, O.; Department of Molecular Biology, Hungary; email: kapuy.orsolya@semmelweis.hu Chemicals/CAS: caspase 3, 169592-56-7; caspase 7, 189258-14-8; doublecortin like kinase 1; epigallocatechin gallate, 989-51-5; germinal center kinase; glyceraldehyde 3 pho...</pre> </div></div>