https://m2.mtmt.hu/ hun 2026-10-23 06:13 JournalArticle 34544485 VALIDATED true 0 false 2026-09-22T16:25:52.975+0000 2025-03-06T08:03:04.834+0000 2024-01-30T12:17:55.467+0000 true 10068186 Jezsó Bálint /api/author/10068186 Author true 2025-03-17T19:01:59.224+0000 2025-03-17T19:01:59.224+0000 2025-03-06T08:03:05.021+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:43.524+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tordai, Csongor Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling true true /api/journal/4014 REVIEWED true false 4014 false 4014 true 0920-9964 1573-2509 Journal FOREIGN 273 107 120 107 14 2024 Background: Schizophrenia (SCZ) is a severe neuropsychiatric disorder of complex, poorly understood etiology, associated with both genetic and environmental factors. De novo mutations (DNMs) represent a new source of genetic variation in SCZ, however, in most cases their biological significance remains unclear. We sought to investigate molecular disease pathways connected to DNMs in SCZ by combining human induced pluripotent stem cell (hiPSC) based disease modeling and CRISPR-based genome editing. Methods: We selected a SCZ case-parent trio with the case individual carrying a potentially disease causing 1495C > T nonsense DNM in the zinc finger MYND domain-containing protein 11 (ZMYND11), a gene implicated in biological processes relevant for SCZ. In the patient-derived hiPSC line the mutation was corrected using CRISPR, while monoallelic or biallelic frameshift mutations were introduced into a control hiPSC line. Isogenic cell lines were differentiated into hippocampal neuronal progenitor cells (NPCs) and functionally active dentate gyrus granule cells (DGGCs). Immunofluorescence microscopy and RNA sequencing were used to test for morphological and transcriptomic differences at NPC and DGCC stages. Functionality of neurons was investigated using calcium-imaging and multi-electrode array measurements. Results: Morphology in the mutant hippocampal NPCs and neurons was preserved, however, we detected significant transcriptomic and functional alterations. RNA sequencing showed massive upregulation of neuronal differentiation genes, and downregulation of cell adhesion genes. Decreased reactivity to glutamate was demonstrated by calcium-imaging. Conclusions: Our findings lend support to the involvement of glutamatergic dysregulation in the pathogenesis of SCZ. This approach represents a powerful model system for precision psychiatry and pharmacological research. © 2024 The Authors Funding 2042688 /api/funding/2042688 false true Funding 2042689 /api/funding/2042689 false true Funding 2042690 /api/funding/2042690 false true Funding 2042691 /api/funding/2042691 false true Funding 2042692 /api/funding/2042692 false true Funding 2042693 /api/funding/2042693 false true true true 2024 true true true false true false NONE 2026-09-22 false 3 0 3 2 1 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 5 5 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 2 1 2 1 Q1 false 10027529 false false false 2024-05-15T08:18:10.469+0000 Biokémiai és Molekuláris Biológiai Intézet (DE / ÁOK); Genomikai Medicina és Ritka Betegségek Intézete (SE / AOK / I); Molekuláris Pszichiátria és In Vitro Betegségmo... (SE / AOK / K / PPK); Molekuláris Élettudományi Intézet (HRN TTK); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 13 49 5 14 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 114151229 /api/authorship/114151229 1 0.071 true false false Author 10077215 /api/author/10077215 Tordai Csongor Balázs true true Tordai Csongor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151230 /api/authorship/114151230 2 0.071 false false false Author 10059295 /api/author/10059295 Hathy Edit Margit true 10059295 true Hathy Edit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151231 /api/authorship/114151231 3 0.071428575 false false false Gyergyák Hella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151232 /api/authorship/114151232 4 0.071 false false false Author 10070227 /api/author/10070227 Vincze Katalin true true Vincze Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151233 /api/authorship/114151233 5 0.071 false false false Author 10047953 /api/author/10047953 Baradits Máté true 10047953 true Baradits Máté true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151234 /api/authorship/114151234 6 0.071 false false false Author 10040685 /api/author/10040685 Koller Júlia true 10040685 true Koller Júlia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151235 /api/authorship/114151235 7 0.071 false false false Author 10058709 /api/author/10058709 Póti Ádám true 10058709 true Póti Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151236 /api/authorship/114151236 8 0.071 false false false Author 10068186 /api/author/10068186 Jezsó Bálint true true Jezsó Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151237 /api/authorship/114151237 9 0.071 false false false Author 10010446 /api/author/10010446 Homolya László true 10010446 true Homolya László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151238 /api/authorship/114151238 10 0.071 false false false Author 10002781 /api/author/10002781 Molnár Mária Judit true 10002781 true Molnár Mária Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151239 /api/authorship/114151239 11 0.071 false false false Author 10000389 /api/author/10000389 Nagy László true 10000389 true Nagy László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151240 /api/authorship/114151240 12 0.071 false false true Author 10026660 /api/author/10026660 Szüts Dávid true 10026660 true Szüts Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151241 /api/authorship/114151241 13 0.071 false false true Author 10027529 /api/author/10027529 Apáti Ágota true 10027529 true Apáti Ágota true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114151242 /api/authorship/114151242 14 0.071 false true true Author 10021998 /api/author/10021998 Réthelyi János true 10021998 true Réthelyi János M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25389854 /api/publicationidentifier/25389854 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.schres.2024.01.024 https://doi.org/10.1016/j.schres.2024.01.024 false true PublicationIdentifier 28101244 /api/publicationidentifier/28101244 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001360872200001 https://www.webofscience.com/wos/woscc/full-record/001360872200001 true true PublicationIdentifier 25749199 /api/publicationidentifier/25749199 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85185171099 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185171099 true true PublicationIdentifier 25508212 /api/publicationidentifier/25508212 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38290943 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38290943&dopt=Abstract false true Classification 12318 /api/classification/12318 true true Keyword 151 /api/keyword/151 true 151 true Keyword 1419272 /api/keyword/1419272 true 1419272 true Keyword 1534225 /api/keyword/1534225 true true Keyword 3358883 /api/keyword/3358883 true true Keyword 3358884 /api/keyword/3358884 true true SjrRating 11495509 /api/sjrrating/11495509 138 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2738 /api/classificationexternal/2738 true 2738 true Q1 DIRECT true true Reference 49563955 /api/reference/49563955 1 false true Reference 49563956 /api/reference/49563956 2 10.1016/j.nbd.2018.04.021 false true Reference 49563957 /api/reference/49563957 3 10.1038/nbt.3519 false true Reference 49563958 /api/reference/49563958 4 10.1176/appi.ajp.20220235 false true Reference 49563959 /api/reference/49563959 5 10.1038/nature09915 false true Reference 49563960 /api/reference/49563960 6 10.21873/anticanres.13477 false true Reference 49563961 /api/reference/49563961 7 10.1038/ng.3092 false true Reference 49563962 /api/reference/49563962 8 10.1007/978-3-642-25758-2_10 false true Reference 49563963 /api/reference/49563963 9 10.3109/10428194.2013.820292 false true Reference 49563964 /api/reference/49563964 10 10.1186/s40478-022-01460-2 false true Reference 49563965 /api/reference/49563965 11 10.1016/j.schres.2020.09.013 false true Reference 49563966 /api/reference/49563966 12 10.1002/cytob.21168 false true Reference 49563967 /api/reference/49563967 13 10.1038/s41537-017-0033-5 false true Reference 49563968 /api/reference/49563968 14 10.2183/pjab.85.348 false true Reference 49563969 /api/reference/49563969 15 10.1038/s41398-019-0488-4 false true Reference 49563970 /api/reference/49563970 16 10.1016/j.molcel.2014.08.022 false true Reference 49563971 /api/reference/49563971 17 10.1016/j.neurobiolaging.2014.05.014 false true Reference 49563972 /api/reference/49563972 18 10.1016/j.neuron.2016.05.034 false true Reference 49563973 /api/reference/49563973 19 10.1186/s13287-020-01980-5 false true Reference 49563974 /api/reference/49563974 20 10.1038/s41380-023-02043-w false true Reference 49563975 /api/reference/49563975 21 10.1016/j.neuron.2012.01.033 false true Reference 49563976 /api/reference/49563976 22 10.1159/000518689 false true Reference 49563977 /api/reference/49563977 23 10.1016/S0140-6736(21)01730-X false true Reference 49563978 /api/reference/49563978 24 10.1016/j.neuron.2013.03.016 false true Reference 49563979 /api/reference/49563979 25 10.1038/nrdp.2015.67 false true Reference 49563980 /api/reference/49563980 26 10.1038/s41398-019-0660-x false true Reference 49563981 /api/reference/49563981 27 10.1001/jamapsychiatry.2020.0196 false true Reference 49563982 /api/reference/49563982 28 10.1038/s41587-019-0201-4 false true Reference 49563983 /api/reference/49563983 29 10.1016/j.neuron.2019.05.002 false true Reference 49563984 /api/reference/49563984 30 10.1093/bioinformatics/bty897 false true Reference 49563985 /api/reference/49563985 31 10.1073/pnas.1418996111 false true Reference 49563986 /api/reference/49563986 32 10.1017/S0033291720005334 false true Reference 49563987 /api/reference/49563987 33 10.1523/JNEUROSCI.23-15-06171.2003 false true Reference 49563988 /api/reference/49563988 34 10.1038/s41467-021-21357-3 false true Reference 49563989 /api/reference/49563989 35 10.1093/bioinformatics/btt656 false true Reference 49563990 /api/reference/49563990 36 10.1038/s41588-023-01305-1 false true Reference 49563991 /api/reference/49563991 37 10.1186/s13059-014-0550-8 false true Reference 49563992 /api/reference/49563992 38 10.1038/ncomms15079 false true Reference 49563993 /api/reference/49563993 39 10.1016/j.conb.2021.04.003 false true Reference 49563994 /api/reference/49563994 40 10.1016/j.schres.2018.12.023 false true Reference 49563995 /api/reference/49563995 41 10.1038/s41380-023-02005-2 false true Reference 49563996 /api/reference/49563996 42 10.1016/j.schres.2016.10.012 false true Reference 49563997 /api/reference/49563997 43 false true Reference 49563998 /api/reference/49563998 44 10.1016/j.schres.2016.12.012 false true Reference 49563999 /api/reference/49563999 45 10.1111/cge.14023 false true Reference 49564000 /api/reference/49564000 46 10.1152/physrev.00039.2011 false true Reference 49564001 /api/reference/49564001 47 10.1007/7651_2014_68 false true Reference 49564002 /api/reference/49564002 48 10.1038/nmeth.4324 false true Reference 49564003 /api/reference/49564003 49 10.1016/S0924-977X(16)31017-3 false true Reference 49564004 /api/reference/49564004 50 10.1016/j.tins.2021.11.002 false true Reference 49564005 /api/reference/49564005 51 10.1016/j.neubiorev.2013.04.010 false true Reference 49564006 /api/reference/49564006 52 10.1016/j.stem.2018.04.009 false true Reference 49564007 /api/reference/49564007 53 10.1038/s41380-020-0844-z false true Reference 49564008 /api/reference/49564008 54 10.1038/s41593-018-0295-x false true Reference 49564009 /api/reference/49564009 55 10.1038/s41588-019-0497-5 false true Reference 49564010 /api/reference/49564010 56 10.1038/s41586-022-04556-w false true Reference 49564011 /api/reference/49564011 57 10.1016/j.celrep.2015.07.061 false true Reference 49564012 /api/reference/49564012 58 10.1016/S1937-6448(10)81003-2 false true Reference 49564013 /api/reference/49564013 59 10.1038/cr.2014.38 false true Reference 49564014 /api/reference/49564014 60 10.1016/j.jphs.2020.02.008 false true Reference 49564015 /api/reference/49564015 61 10.4161/cc.29732 false true Reference 49564016 /api/reference/49564016 62 10.1038/nature13045 false true Reference 49564017 /api/reference/49564017 63 10.1186/1471-2164-13-S8-S2 false true Reference 49564018 /api/reference/49564018 64 10.1038/mp.2016.163 false true Reference 49564019 /api/reference/49564019 65 10.1016/j.str.2017.08.014 false true Reference 49564020 /api/reference/49564020 66 10.1002/humu.24001 false true Reference 49564021 /api/reference/49564021 67 10.1016/j.yexcr.2009.09.011 false true Reference 49564022 /api/reference/49564022 68 10.1089/omi.2011.0118 false true Reference 49564023 /api/reference/49564023 69 10.1016/j.stemcr.2014.01.009 false true Reference 49564024 /api/reference/49564024 70 10.1111/bpa.12194 false true Reference 49564025 /api/reference/49564025 71 false true Reference 49564026 /api/reference/49564026 72 false true Reference 49564027 /api/reference/49564027 73 false true Reference 49564028 /api/reference/49564028 74 false true /api/publication/34544485 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077215"><a href="/gui2/?type=authors&mode=browse&sel=10077215" target="_blank">Tordai Csongor (<span class="authorship-author-name">Tordai Csongor Balázs</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Molekuláris Pszichiátria és In Vitro Betegségmodellezési Kutatócsoport; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059295"><a href="/gui2/?type=authors&mode=browse&sel=10059295" target="_blank">Hathy Edit (<span class="authorship-author-name">Hathy Edit Margit</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Molekuláris Pszichiátria és In Vitro Betegségmodellezési Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gyergyák Hella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070227"><a href="/gui2/?type=authors&mode=browse&sel=10070227" target="_blank">Vincze Katalin (<span class="authorship-author-name">Vincze Katalin</span> <span class="authorAux-mtmt"> Pszichiátriai genetika.</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Molekuláris Pszichiátria és In Vitro Betegségmodellezési Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047953"><a href="/gui2/?type=authors&mode=browse&sel=10047953" target="_blank">Baradits Máté (<span class="authorship-author-name">Baradits Máté</span> <span class="authorAux-mtmt"> Pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Molekuláris Pszichiátria és In Vitro Betegségmodellezési Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040685"><a href="/gui2/?type=authors&mode=browse&sel=10040685" target="_blank">Koller Júlia (<span class="authorship-author-name">Koller Júlia</span> <span class="authorAux-mtmt"> Biokémia, bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genomikai Medicina és Ritka Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Molekuláris Pszichiátria és In Vitro Betegségmodellezési Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058709"><a href="/gui2/?type=authors&mode=browse&sel=10058709" target="_blank">Póti Ádám (<span class="authorship-author-name">Póti Ádám</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068186"><a href="/gui2/?type=authors&mode=browse&sel=10068186" target="_blank">Jezsó Bálint (<span class="authorship-author-name">Jezsó Bálint</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya László (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002781"><a href="/gui2/?type=authors&mode=browse&sel=10002781" target="_blank">Molnár Mária Judit (<span class="authorship-author-name">Molnár Mária Judit</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genomikai Medicina és Ritka Betegségek Intézete</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000389"><a href="/gui2/?type=authors&mode=browse&sel=10000389" target="_blank">Nagy László (<span class="authorship-author-name">Nagy László</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026660"><a href="/gui2/?type=authors&mode=browse&sel=10026660" target="_blank">Szüts Dávid ✉ (<span class="authorship-author-name">Szüts Dávid</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027529"><a href="/gui2/?type=authors&mode=browse&sel=10027529" target="_blank">Apáti Ágota ✉ (<span class="authorship-author-name">Apáti Ágota</span> <span class="authorAux-mtmt"> Őssejt kutatás</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021998"><a href="/gui2/?type=authors&mode=browse&sel=10021998" target="_blank">Réthelyi János M. ✉ (<span class="authorship-author-name">Réthelyi János</span> <span class="authorAux-mtmt"> Pszichiátria- kognítiv idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Molekuláris Pszichiátria és In Vitro Betegségmodellezési Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34544485" target="_blank">Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling</a></div> <div> <span class="journal-title">SCHIZOPHRENIA RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0920-9964">0920-9964</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-2509">1573-2509</a>)</span>: <span class="journal-volume">273</span> <span class="page"> pp 107-120 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.schres.2024.01.024" target="_blank" href="https://doi.org/10.1016/j.schres.2024.01.024"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001360872200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001360872200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85185171099" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85185171099"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38290943" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38290943&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Psychiatry and Mental Health&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biological Psychiatry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34544485&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34544485</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Nemzeti Agykutatási Program, NAP(NAP-B KTIA_NAP_13-2014-0011), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (NAP-A KTIA_13_NAP-A-I/6), (TKP2021-EGA25), (GINOP-2.1.1-15-2015-00369), (RG-IPI-2016 TP10/015) </div> <div class="lastModified">Utolsó módosítás: 2025.03.06. 09:03 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:27 Vándor Andrea (VA, admin) </div> </div></div>