https://m2.mtmt.hu/ hun 2026-05-30 23:10 JournalArticle 34538356 VALIDATED true * Megosztott szerzőség 0 false 2026-05-23T12:53:00.596+0000 2024-02-13T09:35:59.105+0000 2024-01-28T09:36:07.346+0000 true 10013024 Molnár Gergő Attila /api/author/10013024 Author true 10013024 2026-05-04T13:10:58.471+0000 2026-05-04T13:10:58.471+0000 2024-02-13T09:35:59.353+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Molnár, Gergő Attila Effectiveness of SARS-CoV-2 primary vaccines and boosters in patients with type 2 diabetes mellitus in Hungary (HUN-VE 4 Study) true true /api/journal/10042382 REVIEWED true false 10042382 false 10042382 true 2052-4897 Journal FOREIGN 12 1 e003777 e003777 10 2024 Introduction Type 2 diabetes mellitus is a risk factor for severe COVID-19 infection and is associated with increased risk of complications. The present study aimed to investigate effectiveness and persistence of different COVID vaccines in persons with or without diabetes during the Delta wave in Hungary.Research design and methods Data sources were the national COVID-19 registry data from the National Public Health Center and the National Health Insurance Fund on the total Hungarian population. The adjusted incidence rate ratios and corresponding 95% CIs were derived from a mixed-effect negative binomial regression model.Results A population of 672 240 cases with type 2 diabetes and a control group of 2 974 102 non-diabetic persons free from chronic diseases participated. Unvaccinated elderly persons with diabetes had 2.68 (95% CI 2.47 to 2.91) times higher COVID-19-related mortality rate as the ‘healthy’ controls. Primary immunization effectively equalized the risk of COVID-19 mortality between the two groups. Vaccine effectiveness declined over time, but the booster restored the effectiveness against mortality to over 90%. The adjusted vaccine effectiveness of the primary Pfizer-BioNTech against infection in the 14–120 days of postvaccination period was 71.6 (95% CI 66.3 to 76.1)% in patients aged 65–100 years with type 2 diabetes and 64.52 (95% CI 59.2 to 69.2)% in the controls. Overall, the effectiveness tended to be higher in individuals with diabetes than in controls. The booster vaccines could restore vaccine effectiveness to over 80% concerning risk of infection (eg, patients with diabetes aged 65–100 years: 89.1 (88.1–89.9)% with Pfizer-on-Pfizer, controls 65–100 years old: 86.9 (85.8–88.0)% with Pfizer-on-Pfizer, or patients with diabetes aged 65–100 years: 88.3 (87.2–89.2)% with Pfizer-on-Sinopharm, controls 65–100 years old: 87.8 (86.8–88.7)% with Pfizer-on-Sinopharm).Conclusions Our data suggest that people with type 2 diabetes may have even higher health gain when getting vaccinated as compared with non-diabetic persons, eliminating the marked, COVID-19-related excess risk of this population. Boosters could restore protection.Data are available upon reasonable request. true true 2024 true true true false true false GOLD 2026-05-23 true https://doi.org/10.1136/bmjdrc-2023-003777 12 0 12 12 0 12 12 12 11 12 12 12 12 12 0 0 12 12 12 12 0 3 3 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 6 6 6 6 2025 0 5 5 5 5 2026 0 1 1 1 1 Q1 false 10028053 false false false 2024-01-28T09:53:10.761+0000 Digitális Egészségtudományi Intézet (SE / EKK); Egészségügyi Technológiaértékelő és Elemzési Kö... (SE / KSZE); II. sz. Belgyógyászati Klinika és Nephrológiai,... (PTE / ÁOK); Országos Onkológiai Intézet; Patológiai, Igazságügyi és Biztosítási Orvostan... 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38267204&dopt=Abstract false true SjrRating 11462251 /api/sjrrating/11462251 34 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2712 /api/classificationexternal/2712 true 2712 true Q1 DIRECT true true /api/publication/34538356 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10013024"><a href="/gui2/?type=authors&mode=browse&sel=10013024" target="_blank">Molnár Gergő Attila (<span class="authorship-author-name">Molnár Gergő Attila</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000181"><a href="/gui2/?type=authors&mode=browse&sel=10000181" target="_blank">Vokó Zoltán<sup>*</sup> (<span class="authorship-author-name">Vokó Zoltán</span> <span class="authorAux-mtmt"> A nem-fertőző betegségek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Egészségügyi Technológiaértékelő és Elemzési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010793"><a href="/gui2/?type=authors&mode=browse&sel=10010793" target="_blank">Sütő Gábor (<span class="authorship-author-name">Sütő Gábor</span> <span class="authorAux-mtmt"> Klinikai immunológia és reumatológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080246"><a href="/gui2/?type=authors&mode=browse&sel=10080246" target="_blank">Rokszin György (<span class="authorship-author-name">Rokszin György Aurél</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagy Dávid </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028053"><a href="/gui2/?type=authors&mode=browse&sel=10028053" target="_blank">Surján György (<span class="authorship-author-name">Surján György</span> <span class="authorAux-mtmt"> Orvosi informatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségügyi Közszolgálati Kar">EKK</span>/Digitális Egészségtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Surján Orsolya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021022"><a href="/gui2/?type=authors&mode=browse&sel=10021022" target="_blank">Nagy Péter (<span class="authorship-author-name">Nagy Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017547"><a href="/gui2/?type=authors&mode=browse&sel=10017547" target="_blank">Kenessey István (<span class="authorship-author-name">Kenessey István</span> <span class="authorAux-mtmt"> Patológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064611"><a href="/gui2/?type=authors&mode=browse&sel=10064611" target="_blank">Wéber András (<span class="authorship-author-name">Wéber András</span> <span class="authorAux-mtmt"> Demográfia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pálosi Mihály </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Müller Cecília </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024576"><a href="/gui2/?type=authors&mode=browse&sel=10024576" target="_blank">Kásler Miklós (<span class="authorship-author-name">Kásler Miklós</span> <span class="authorAux-mtmt"> Klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016656"><a href="/gui2/?type=authors&mode=browse&sel=10016656" target="_blank">Wittmann István ✉ (<span class="authorship-author-name">Wittmann István</span> <span class="authorAux-mtmt"> Klinikai orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077079"><a href="/gui2/?type=authors&mode=browse&sel=10077079" target="_blank">Kiss Zoltan (<span class="authorship-author-name">Kiss Zoltán</span> <span class="authorAux-mtmt"> A főbb mortalitásért felelős betegségek epidemi...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34538356" target="_blank">Effectiveness of SARS-CoV-2 primary vaccines and boosters in patients with type 2 diabetes mellitus in Hungary (HUN-VE 4 Study)</a></div> <div> <span class="journal-title">BMJ OPEN DIABETES RESEARCH & CARE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2052-4897">2052-4897</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">1</span> <span class="page"> Paper e003777. 10 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1136/bmjdrc-2023-003777" target="_blank" href="https://doi.org/10.1136/bmjdrc-2023-003777"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001153876600003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001153876600003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85183336004" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85183336004"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38267204" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38267204&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 12 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;12 | DOI jelölt:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34538356&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34538356</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="lastModified">Utolsó módosítás: 2024.02.13. 10:35 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>