https://m2.mtmt.hu/ hun 2026-09-23 04:47 JournalArticle 34530291 VALIDATED true 0 false 2026-09-13T21:00:44.936+0000 2024-06-24T08:52:30.423+0000 2024-01-24T18:37:31.400+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin Tichy Rita (SE_KK_Admin5_TR, admin) true 10026589 2026-04-08T13:18:16.097+0000 2026-04-08T13:18:16.097+0000 2024-02-12T11:13:35.321+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2025-05-15T11:48:49.146+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Köles, László true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 2 719 719 31 2024 This review summarizes the current understanding of the role of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. The TRPM family represents the largest and most diverse group in the TRP superfamily. Its subtypes are expressed in virtually all human organs playing a central role in (patho)physiological events. The TRPM7 protein (along with TRPM2 and TRPM6) is unique in that it has kinase activity in addition to the channel function. Numerous studies demonstrate the role of TRPM7 chanzyme in tumorigenesis and in other tumor hallmarks such as proliferation, migration, invasion and metastasis. Here we provide an up-to-date overview about the possible role of TRMP7 in a broad range of malignancies such as tumors of the nervous system, head and neck cancers, malignant neoplasms of the upper gastrointestinal tract, colorectal carcinoma, lung cancer, neoplasms of the urinary system, breast cancer, malignant tumors of the female reproductive organs, prostate cancer and other neoplastic pathologies. Experimental data show that the increased expression and/or function of TRPM7 are observed in most malignant tumor types. Thus, TRPM7 chanzyme may be a promising target in tumor therapy. Funding 2036741 /api/funding/2036741 Hungarian Scientific Research Fund(NKFI K128875) false true Funding 2036742 /api/funding/2036742 (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium false true true true 2024 true true true false true false GOLD 2026-09-13 true https://doi.org/10.3390/ijms25020719 24 0 24 24 0 24 24 23 21 24 24 24 24 24 0 0 24 24 24 24 0 4 4 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 4 4 4 4 2025 0 9 9 9 9 2026 0 10 10 10 10 D1 false 10015697 false false false 2024-02-11T11:13:35.052+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Molekuláris Farmakológia Kutatócsoport (HRN KOKI); Orálbiológiai Tanszék (SE / FOK) 6 24 3 6 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 114085576 /api/authorship/114085576 Köles, László [Köles, László (Farmakológia), szerző] Orálbiológiai Tanszék (SE / FOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 1 0.167 true false false Author 10015482 /api/author/10015482 Köles László (Farmakológia) Köles László true 10015482 true Köles László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114085577 /api/authorship/114085577 Ribiczey, Polett [Szentirmainé Ribiczey, Polett (Farmakológia), szerző] Orálbiológiai Tanszék (SE / FOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 2 0.167 false false false Author 10069236 /api/author/10069236 Szentirmainé Ribiczey Polett (Farmakológia) Szentirmainé Ribiczey Polett true true Ribiczey Polett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114085578 /api/authorship/114085578 Szebeni, Andrea [Szebeni, Andrea (Farmakológia), szerző] 3 0.167 false false false Author 10024055 /api/author/10024055 Szebeni Andrea (Farmakológia) Szebeni Andrea true 10024055 true Szebeni Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114085579 /api/authorship/114085579 Kádár, Kristóf [Kádár, Kristóf György (Orálbiológia), szerző] Orálbiológiai Tanszék (SE / FOK) 4 0.167 false false false Author 10018991 /api/author/10018991 Kádár Kristóf György (Orálbiológia) Kádár Kristóf György true 10018991 true Kádár Kristóf true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114085580 /api/authorship/114085580 Zelles, Tibor [Zelles, Tibor (Idegtudományok), szerző] Orálbiológiai Tanszék (SE / FOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Molekuláris Farmakológia Kutatócsoport (HRN KOKI) 5 0.167 false false false Author 10000028 /api/author/10000028 Zelles Tibor (Idegtudományok) Zelles Tibor true 10000028 true Zelles Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 114085581 /api/authorship/114085581 Zsembery, Ákos ✉ [Zsembery, Ákos (Élettan), szerző] Orálbiológiai Tanszék (SE / FOK) 6 0.167 false true true Author 10015697 /api/author/10015697 Zsembery Ákos (Élettan) Zsembery Ákos true 10015697 true Zsembery Ákos true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 25357828 /api/publicationidentifier/25357828 DOI: 10.3390/ijms25020719 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25020719 https://doi.org/10.3390/ijms25020719 false true PublicationIdentifier 25430091 /api/publicationidentifier/25430091 REAL: 187659 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 187659 https://real.mtak.hu/187659 false true PublicationIdentifier 25461937 /api/publicationidentifier/25461937 WoS: 001151453900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001151453900001 https://www.webofscience.com/wos/woscc/full-record/001151453900001 true true PublicationIdentifier 25461938 /api/publicationidentifier/25461938 Scopus: 85183208238 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85183208238 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85183208238 true true PublicationIdentifier 25357829 /api/publicationidentifier/25357829 PubMed: 38255793 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38255793 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38255793&dopt=Abstract false true Keyword 643 /api/keyword/643 CANCER true 643 true Keyword 683 /api/keyword/683 MALIGNANCY true 683 true Keyword 19622 /api/keyword/19622 neoplasm true 19622 true Keyword 1533649 /api/keyword/1533649 Chanzyme true true Keyword 3287701 /api/keyword/3287701 tumor hallmarks true true Keyword 3290433 /api/keyword/3290433 TRPM7 channel true true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 49319313 /api/reference/49319313 1. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 2<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015482"><a href="/gui2/?type=authors&mode=browse&sel=10015482" target="_blank">Köles László (<span class="authorship-author-name">Köles László</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069236"><a href="/gui2/?type=authors&mode=browse&sel=10069236" target="_blank">Ribiczey Polett (<span class="authorship-author-name">Szentirmainé Ribiczey Polett</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024055"><a href="/gui2/?type=authors&mode=browse&sel=10024055" target="_blank">Szebeni Andrea (<span class="authorship-author-name">Szebeni Andrea</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018991"><a href="/gui2/?type=authors&mode=browse&sel=10018991" target="_blank">Kádár Kristóf (<span class="authorship-author-name">Kádár Kristóf György</span> <span class="authorAux-mtmt"> Orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000028"><a href="/gui2/?type=authors&mode=browse&sel=10000028" target="_blank">Zelles Tibor (<span class="authorship-author-name">Zelles Tibor</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Molekuláris Farmakológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015697"><a href="/gui2/?type=authors&mode=browse&sel=10015697" target="_blank">Zsembery Ákos ✉ (<span class="authorship-author-name">Zsembery Ákos</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34530291" target="_blank">The Role of TRPM7 in Oncogenesis</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">2</span> <span class="page"> Paper 719. 31 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25020719" target="_blank" href="https://doi.org/10.3390/ijms25020719"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="187659" target="_blank" href="https://real.mtak.hu/187659"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001151453900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001151453900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85183208238" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85183208238"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38255793" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38255793&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 24</span> | Független: 24 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 23 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;24 | DOI jelölt:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34530291&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34530291</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Scientific Research Fund(NKFI K128875), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2024.06.24. 10:52 Turek Márta (KOKI admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.05.15. 13:48 Vándor Andrea (VA, admin) </div> </div></div>