https://m2.mtmt.hu/ hun 2026-09-21 05:43 JournalArticle 34524844 VALIDATED true 0 false 2026-07-21T08:41:19.084+0000 2025-11-21T07:42:53.104+0000 2024-01-23T07:59:04.906+0000 true 10028537 Baczkó Gabriella /api/admin/10028537 Admin true 10028537 2025-11-21T07:42:49.119+0000 2026-04-10T07:40:25.975+0000 2025-11-21T07:42:53.113+0000 true 10097128 Sass Dávid /api/admin/10097128 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Vereckei, András Novel electrocardiographic criteria may render possible the more accurate recognition of cardiac amyloidosis true true /api/journal/10035112 REVIEWED true false 10035112 false 10035112 true 2055-5822 2055-5822 Journal FOREIGN 11 2 1030 1038 1030 9 2024 The early diagnosis of cardiac amyloidosis (CA) is paramount, since there are effective therapies that improve patient survival. The diagnostic accuracy of classical electrocardiographic (ECG) signs, such as low voltage, pseudoinfarct pattern, and conduction disturbances in the diagnosis of CA, is inferior to that of the echocardiographic myocardial deformation criteria; therefore, our aim was to find more accurate novel ECG criteria for this purpose.We tested the diagnostic value of five novel ECG criteria, two of them devised by us, in 34 patients with confirmed CA (20 transthyretin amyloidosis and 14 AL amyloidosis) and 45 control patients with left ventricular hypertrophy on echocardiography due to hypertension, valvular aortic stenosis and hypertrophic cardiomyopathy. The following novel ECG criteria, that suggested CA, were tested: QRS amplitude in lead I < 0.55 mV (I < 0.55); QRS amplitude in lead aVR < 0.5 mV (aVR < 0.5); average QRS amplitude of leads I + aVR < 0.575 mV [(I + aVR) < 0.575]; average QRS amplitude of leads I + aVR/average QRS amplitude of leads V1-4 < 0.375 [(I + aVR)/(V1-4 ) < 0.375]; average QRS amplitude of leads I + aVR/longest intrinsicoid deflection in leads I,aVL,V1-6 < 0.0115 [(I + aVR)/I,aVL,V1-6 ID < 0.0115].The I < 0.55, aVR < 0.5, (I + aVR) < 0.575, (I + aVR)/(V1-4 ) < 0.375, (I + aVR)/I,aVL,V1-6 ID < 0.0115 test accuracy (TA) were 81%, 84.8%, 82.3%, 84.8%, and 83.3%, respectively; the sensitivity (SE): 76.5%, 82.4%, 85.3%, 82.4%, and 76.9%; specificity (SP): 84.4%, 86.7%, 80%, 86.7%, and 87.5%; positive predictive values (PPV): 78.8%, 82.4%, 76.3%, 82.4%, and 80%; negative predictive values (NPV): 82.6%, 86.7%, 87.8%, 86.7%, and 85.4%; area under curve (AUC) values: 0.8922, 0.8794, 09016, 0.8824, and 0.8462 were respectively. These parameters of the novel ECG criteria were at least as good as those reported by other authors in the literature of the qualitative (TA: 67%, SE: 80%, SP: 34%, PPV: 75%, NPV: 42%, AUC: 0.57) and quantitative apical sparing (TA: 64-80%, SE: 66-81.3%, SP: 55-78.3%, PPV: 33-83.9%, NPV: 41-75%, AUC: 0.62-0.68) and left ventricular ejection fraction/global longitudinal strain >4.1 (TA: 77%, SE: 93%, SP: 38%, PPV: 79%, NPV: 69%, AUC: 0.65) echocardiographic criteria. Among the classical criteria, the low voltage in limb leads criterion was present most frequently (in 73.5%) in patients with CA, with slightly worse diagnostic value than the novel ECG criteria (TA: 78.5%, SE: 73.5%, SP: 82.2%, PPV: 75.8%, NPV: 80.4%).The novel ECG criteria [mostly the aVR < 0.5, (I + aVR)/(V1-4 ) < 0.375] seem at least as reliable in the diagnosis of CA as the best echocardiographic myocardial deformation criteria and might be used either together with the echocardiographic criteria or as stand-alone criteria to diagnose CA in the future. true 2024 true true true false true false GOLD 2026-07-21 true http://publicatio.bibl.u-szeged.hu/29387 6 0 6 6 1 5 6 4 4 5 5 5 5 6 0 0 6 6 6 6 0 0 0 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás 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sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/34524844 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10009105"><a href="/gui2/?type=authors&mode=browse&sel=10009105" target="_blank">Vereckei András ✉ (<span class="authorship-author-name">Vereckei András</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051365"><a href="/gui2/?type=authors&mode=browse&sel=10051365" target="_blank">Katona Gábor (<span class="authorship-author-name">Katona Gábor</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027489"><a href="/gui2/?type=authors&mode=browse&sel=10027489" target="_blank">Szénási Gábor (<span class="authorship-author-name">Szénási Gábor</span> <span class="authorAux-mtmt"> kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095524"><a href="/gui2/?type=authors&mode=browse&sel=10095524" target="_blank">Vidács László Dániel (<span class="authorship-author-name">Vidács Dániel László</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049745"><a href="/gui2/?type=authors&mode=browse&sel=10049745" target="_blank">Földeák Dóra (<span class="authorship-author-name">Földeák Dóra Melinda</span> <span class="authorAux-mtmt"> belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054395"><a href="/gui2/?type=authors&mode=browse&sel=10054395" target="_blank">Takács Hedvig (<span class="authorship-author-name">Takács Hedvig</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049831"><a href="/gui2/?type=authors&mode=browse&sel=10049831" target="_blank">Nagy Viktória (<span class="authorship-author-name">Nagy Viktória</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036081"><a href="/gui2/?type=authors&mode=browse&sel=10036081" target="_blank">Sepp Róbert (<span class="authorship-author-name">Sepp Róbert</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34524844" target="_blank">Novel electrocardiographic criteria may render possible the more accurate recognition of cardiac amyloidosis</a></div> <div> <span class="journal-title">ESC HEART FAILURE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2055-5822">2055-5822</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2055-5822">2055-5822</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">2</span> <span class="page"> pp 1030-1038 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/ehf2.14655" target="_blank" href="https://doi.org/10.1002/ehf2.14655"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001145886100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001145886100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85182643971" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85182643971"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38243379" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38243379&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="29387" target="_blank" href="http://publicatio.bibl.u-szeged.hu/29387"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 6 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;6 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34524844</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.11.21. 08:42 Sass Dávid (SZTE admin5) </div> </div></div>