Promising research results have been obtained on the tissue-regeneration properties
of PRF (platelet-rich fibrin) in dentistry and maxillofacial surgery. PRF presumably
promotes healing and accelerates ossification. In this case report, the patient had
a history of Gorlin–Goltz syndrome, also called nevoid basal cell carcinoma syndrome,
an autosomal dominant neurocutaneous disease that was known for many years. As a consequence,
cysts were detected in both the mandible and maxilla. We performed decompression on
this 37-year-old patient, followed by a cystectomy on an extensive lesion in the right
angle of the mandible. One cyst from each side of the body mandible and one from the
maxilla were completely enucleated, as determined using an intraoral exploration.
The resulting bone defect was filled with a composite graft composed of a mixture
of A-PRF and a serum albumin-coated bone allograft (BoneAlbumin). The wound was then
covered with a PRF membrane. The surgical sites were closed per primam. The postoperative
period was uneventful. Biopsies were performed after three and six months of healing
for histological micromorphometry analyses. Dental implants were placed at the sampling
site. Three months after the implantation, the ossified implants were fitted with
superstructures. To date, no complications have appeared with the bone augmentation.
The authors interpret from the findings that the combination of A-PRF and BoneAlbumin
can be validated as a prosperous bone substitute. It can be safely implanted after
a 3-month ossification period.
