https://m2.mtmt.hu/ hun 2026-09-23 02:38 JournalArticle 34506904 APPROVED true Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary International Training Program in Geroscience, Institute of Biophysics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Translational Medicine, Semmelweis University, Budapest, Hungary Institute for Biomedical Engineering, Science, and Technology (IBEST), University of Oklahoma, Norman, OK, United States Cited By :1 Export Date: 9 January 2025 Correspondence Address: Tang, Q.; Stephenson School of Biomedical Engineering, United States; email: qtang@ou.edu Funding details: National Cancer Institute, NCI Funding details: American Cancer Society, ACS Funding details: National Institute of General Medical Sciences, NIGMS, U54GM104938, P20GM103639 Funding details: National Institute of General Medical Sciences, NIGMS Funding details: National Institutes of Health, NIH, R01CA255840, R01DK133717, 5U01HL152410‐04 Funding details: National Institutes of Health, NIH Funding details: Oklahoma Center for the Advancement of Science and Technology, OCAST, P20 GM135009, HR23‐071 Funding details: Oklahoma Center for the Advancement of Science and Technology, OCAST Funding details: University of Oklahoma Health Sciences Center, OUHSC, P30CA225520 Funding details: University of Oklahoma Health Sciences Center, OUHSC Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS100782 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding details: University of Oklahoma, OU, IRG‐19‐142‐01 Funding details: University of Oklahoma, OU Funding details: American Heart Association, AHA, AHA834339 Funding details: American Heart Association, AHA Funding details: National Institute on Aging, NIA, R01AG055395, R01AG068295, RF1AG072295, R01AG070915, K01AG073614 Funding details: National Institute on Aging, NIA Funding details: National Science Foundation, NSF, 2238648, OIA‐2132161 Funding details: National Science Foundation, NSF Funding text 1: This work was supported by grants from the University of Oklahoma Health Sciences Center (P30CA225520), Faculty Investment Program from University of Oklahoma, Institutional Research Grant number IRG-19-142-01 from the American Cancer Society, National Science Foundation (OIA-2132161, 2238648), National Institute of Health (R01DK133717, R01CA255840, 5U01HL152410-04), Oklahoma Shared Clinical and Translational Resources (NIGMS U54GM104938), Oklahoma Center for the Advancement of Science and Technology (HR23-071), and the medical imaging COBRE (P20 GM135009). Histology service provided by the Tissue Pathology Shared Resource was supported in part by the National Institute of General Medical Sciences COBRE Grant P20GM103639 and National Cancer Institute Grant P30CA225520 of the National Institutes of Health. American Heart Association (ANT: AHA834339), the Oklahoma Center for the Advancement of Science and Technology, the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915, K01AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782). Financial support was provided by the OU Libraries' Open Access Fund. Funding text 2: This work was supported by grants from the University of Oklahoma Health Sciences Center (P30CA225520), Faculty Investment Program from University of Oklahoma, Institutional Research Grant number IRG\\u201019\\u2010142\\u201001 from the American Cancer Society, National Science Foundation (OIA\\u20102132161, 2238648), National Institute of Health (R01DK133717, R01CA255840, 5U01HL152410\\u201004), Oklahoma Shared Clinical and Translational Resources (NIGMS U54GM104938), Oklahoma Center for the Advancement of Science and Technology (HR23\\u2010071), and the medical imaging COBRE (P20 GM135009). Histology service provided by the Tissue Pathology Shared Resource was supported in part by the National Institute of General Medical Sciences COBRE Grant P20GM103639 and National Cancer Institute Grant P30CA225520 of the National Institutes of Health. American Heart Association (ANT: AHA834339), the Oklahoma Center for the Advancement of Science and Technology, the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915, K01AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782). Financial support was provided by the OU Libraries' Open Access Fund. 0 false 2026-07-31T09:34:55.772+0000 2025-02-25T19:14:32.471+0000 2024-01-16T12:17:05.372+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-02-18T14:39:43.979+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-04-30T11:25:22.171+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Yan, F. Dimension-based quantification of aging-associated cerebral microvasculature determined by optical coherence tomography and two-photon microscopy true true /api/journal/10009626 REVIEWED true false 10009626 false 10009626 true 1864-063X 1864-0648 Journal FOREIGN 17 3 e202300409 e202300409 14 2024 Cerebral microvascular health is a key biomarker for the study of natural aging and associated neurological diseases. Our aim is to quantify aging‐associated change of microvasculature at diverse dimensions in mice brain. We used optical coherence tomography (OCT) and two‐photon microscopy (TPM) to obtain nonaged and aged C57BL/6J mice cerebral microvascular images in vivo. Our results indicated that artery & vein, arteriole & venule, and capillary from nonaged and aged mice showed significant differences in density, diameter, complexity, perimeter, and tortuosity. 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