https://m2.mtmt.hu/ hun 2026-09-22 20:17 JournalArticle 34499726 APPROVED true 0 false 2025-09-30T08:35:35.060+0000 2024-03-14T13:18:49.178+0000 2024-01-12T12:59:32.006+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2024-03-14T13:18:49.192+0000 2024-03-14T13:18:49.192+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gerber, Tiemo S. N‐cadherin: A diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas true true /api/journal/2005 REVIEWED true false 2005 false 2005 true 0020-7136 1097-0215 Journal FOREIGN 154 10 1857 1868 1857 12 2024 Distinguishing primary liver cancer (PLC), namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), from liver metastases is of crucial clinical importance. Histopathology remains the gold standard, but differential diagnosis may be challenging. While absent in most epithelial, the expression of the adherens junction glycoprotein N‐cadherin is commonly restricted to neural and mesenchymal cells, or carcinoma cells that undergo the phenomenon of epithelial‐to‐mesenchymal transition (EMT). However, we recently established N‐ and E‐cadherin expression as hallmarks of normal hepatocytes and cholangiocytes, which are also preserved in HCC and iCCA. Therefore, we hypothesized that E‐ and/or N‐cadherin may distinguish between carcinoma derived from the liver vs carcinoma of other origins. We comprehensively evaluated E‐ and N‐cadherin in 3359 different tumors in a multicenter study using immunohistochemistry and compared our results with previously published 882 cases of PLC, including 570 HCC and 312 iCCA. Most carcinomas showed strong positivity for E‐cadherin. Strong N‐cadherin positivity was present in HCC and iCCA. However, except for clear cell renal cell carcinoma (23.6% of cases) and thyroid cancer (29.2%), N‐cadherin was only in some instances faintly expressed in adenocarcinomas of the gastrointestinal tract (0%–0.5%), lung (7.1%), pancreas (3.9%), gynecological organs (0%–7.4%), breast (2.2%) as well as in urothelial (9.4%) and squamous cell carcinoma (0%–5.6%). As expected, N‐cadherin was detected in neuroendocrine tumors (25%–75%), malignant melanoma (46.2%) and malignant mesothelioma (41%). In conclusion, N‐cadherin is a useful marker for the distinction of PLC vs liver metastases of extrahepatic carcinomas ( P < .01). true 2024 true true true false true false NONE 2025-09-30 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q1 B nemzetközi false false false false 2024-04-11T11:59:38.046+0000 II. Sz. Patológiai Intézet (SE / AOK / I) 1 7 1 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 113849827 /api/authorship/113849827 1 0.05882353 true false false Gerber Tiemo S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849828 /api/authorship/113849828 2 0.05882353 false false false Ridder Dirk A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849829 /api/authorship/113849829 3 0.05882353 false false false Goeppert Benjamin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849830 /api/authorship/113849830 4 0.05882353 false false false Brobeil Alexander true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849831 /api/authorship/113849831 5 0.05882353 false false false Stenzel Philipp true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849832 /api/authorship/113849832 6 0.05882353 false false false Zimmer Stefanie true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849833 /api/authorship/113849833 7 0.05882353 false false false Jäkel Jörg true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849834 /api/authorship/113849834 8 0.05882353 false false false Metzig Marie Oliver true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849835 /api/authorship/113849835 9 0.05882353 false false false Schwab Roxana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849836 /api/authorship/113849836 10 0.05882353 false false false Martin Steve Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849837 /api/authorship/113849837 11 0.059 false false false Author 10000554 /api/author/10000554 Kiss András true 10000554 true Kiss András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849838 /api/authorship/113849838 12 0.05882353 false false false Bergmann Frank true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849839 /api/authorship/113849839 13 0.05882353 false false false Schirmacher Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849840 /api/authorship/113849840 14 0.05882353 false false false Galle Peter R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849841 /api/authorship/113849841 15 0.05882353 false false false Lang Hauke true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113849842 /api/authorship/113849842 16 0.05882353 false false false Roth Wilfried true false false 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/api/reference/48735465 47 10.1002/ijc.30400 false true Reference 48735466 /api/reference/48735466 48 10.1111/j.1600-0560.2007.00891.x false true /api/publication/34499726 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Gerber Tiemo S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ridder Dirk A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goeppert Benjamin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brobeil Alexander </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stenzel Philipp </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zimmer Stefanie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jäkel Jörg </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Metzig Marie Oliver </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwab Roxana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Martin Steve Z. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss András (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bergmann Frank </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schirmacher Peter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galle Peter R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lang Hauke </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roth Wilfried </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Straub Beate K. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34499726" target="_blank">N‐cadherin: A diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0020-7136">0020-7136</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-0215">1097-0215</a>)</span>: <span class="journal-volume">154</span> <span class="journal-issue">10</span> <span class="page"> pp 1857-1868 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1002/ijc.34836" target="_blank" href="https://doi.org/10.1002/ijc.34836"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="001141705300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001141705300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85182224656" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85182224656"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="38212892" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38212892&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34499726</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.03.14. 14:18 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>