https://m2.mtmt.hu/ hun 2026-10-23 06:01 JournalArticle 34496994 VALIDATED true 0 false 2026-10-09T16:39:58.992+0000 2025-05-05T14:22:24.743+0000 2024-01-11T13:27:33.548+0000 true 10029701 Matuz Mária /api/admin/10029701 Admin true 10029701 2025-05-05T14:22:15.531+0000 2025-05-05T14:22:15.531+0000 2025-05-05T14:22:24.910+0000 true 10094427 Nyitrai Erzsébet /api/admin/10094427 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Laczkó-Zöld, Eszter The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence a systematic review and meta-analysis of randomized clinical trials true true /api/journal/10081694 REVIEWED true false 10081694 false 10081694 true 2296-861X 2296-861X Journal FOREIGN 10 1200801 1200801 11 2024 Several studies have shown that Momordica charantia L. (Cucurbitaceae, bitter melon) has beneficial effects on metabolic syndrome (MetS) parameters and exerts antidiabetic, anti-hyperlipidemic, and anti-obesity activities. Since the findings of these studies are contradictory, the goal of this systematic review and meta-analysis was to assess the efficacy of bitter melon in the treatment of metabolic syndrome, with special emphasis on the anti-diabetic effect. Embase, Cochrane, PubMed, and Web of Science databases were searched for randomized controlled human trials (RCTs). The meta-analysis was reported according to the PRISMA statement. The primary outcomes of the review are body weight, BMI, fasting blood glucose, glycated hemoglobin A1c, systolic blood pressure, diastolic blood pressure, serum triglyceride, HDL, LDL, and total cholesterol levels. Nine studies were included in the meta-analysis with 414 patients in total and 4–16 weeks of follow-up. In case of the meta-analysis of change scores, no significant effect could be observed for bitter melon treatment over placebo on fasting blood glucose level (MD = −0.03; 95% CI: −0.38 to 0.31; I 2 = 34%), HbA1c level (MD = −0.12; 95% CI: −0.35 to 0.11; I 2 = 56%), HDL (MD = −0.04; 95% CI: −0.17 to 0.09; I 2 = 66%), LDL (MD = −0.10; 95% CI: −0.28 to 0.08; I 2 = 37%), total cholesterol (MD = −0.04; 95% CI: −0.17 to 0.09; I 2 = 66%,), body weight (MD = −1.00; 95% CI: −2.59–0.59; I 2 = 97%), BMI (MD = −0.42; 95% CI: −0.99–0.14; I 2 = 95%), systolic blood pressure (MD = 1.01; 95% CI: −1.07–3.09; I 2 = 0%) and diastolic blood pressure levels (MD = 0.24; 95% CI: −1.04–1.53; I 2 = 0%). Momordica treatment was not associated with a notable change in ALT, AST, and creatinine levels compared to the placebo, which supports the safety of this plant. However, the power was overall low and the meta-analyzed studies were also too short to reliably detect long-term metabolic effects. 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(ÓE / NIK); Farmakognóziai Intézet (SZTE / GYTK); Klinikai Gyógyszerészeti Intézet (SZTE / GYTK); Statisztika Tanszék (BCE / AII); Szentágothai János Kutatóközpont (PTE); Transzlációs Medicina Intézet (PTE / ÁOK); Élettani Szabályozások Kutatóközpont (ÓE / EKIK) 4 38 7 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 113828096 /api/authorship/113828096 1 0.143 true false true Laczkó-Zöld Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113828097 /api/authorship/113828097 2 0.143 true false false Author 10030270 /api/author/10030270 Csupor-Löffler Boglárka true 10030270 true Csupor-Löffler Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113828098 /api/authorship/113828098 3 0.143 true false false Kolcsár Edina-Blanka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113828099 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/api/reference/48678204 71 10.29219/fnr.v66.3685 false true Reference 48678205 /api/reference/48678205 72 10.1089/jmf.2021.0164 false true Reference 48678206 /api/reference/48678206 73 10.1007/s10068-022-01214-9 false true Reference 48678207 /api/reference/48678207 74 10.1016/j.pathophys.2018.05.003 false true Reference 48678208 /api/reference/48678208 75 10.4137/BMI.S38440 false true Reference 48678209 /api/reference/48678209 76 10.1161/CIR.0000000000000625 false true /api/publication/34496994 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Laczkó-Zöld Eszter ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030270"><a href="/gui2/?type=authors&mode=browse&sel=10030270" target="_blank">Csupor-Löffler Boglárka<sup>*</sup> (<span class="authorship-author-name">Csupor-Löffler Boglárka</span> <span class="authorAux-mtmt"> Farmakognózia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Szentágothai János Kutatóközpont; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kolcsár Edina-Blanka<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036214"><a href="/gui2/?type=authors&mode=browse&sel=10036214" target="_blank">Ferenci Tamás (<span class="authorship-author-name">Ferenci Tamás</span> <span class="authorAux-mtmt"> Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="Óbudai Egyetem">ÓE</span>/<span title="Egyetemi Kutató és Innovációs Központ">EKIK</span>/Élettani Szabályozások Kutatóközpont; <span title="Óbudai Egyetem">ÓE</span>/<span title="Neumann János Informatikai Kar">NIK</span>/Biomatika és Alkalmazott Mesterséges Intelligencia Intézet; <span title="Budapesti Corvinus Egyetem">BCE</span>/<span title="Adatelemzés és Informatika Intézet">AII</span>/Statisztika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nan Monica </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044859"><a href="/gui2/?type=authors&mode=browse&sel=10044859" target="_blank">Tóth Barbara (<span class="authorship-author-name">Tóth Barbara</span> <span class="authorAux-mtmt"> Klinikai gyógyszerészet; Farmakognózia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Klinikai Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001143"><a href="/gui2/?type=authors&mode=browse&sel=10001143" target="_blank">Csupor Dezső (<span class="authorship-author-name">Csupor Dezső</span> <span class="authorAux-mtmt"> Klinikai gyógyszerészet; Fitokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Klinikai Gyógyszerészeti Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/Szentágothai János Kutatóközpont; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34496994" target="_blank">The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence : a systematic review and meta-analysis of randomized clinical trials.</a></div> <div> <span class="journal-title">FRONTIERS IN NUTRITION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-861X">2296-861X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-861X">2296-861X</a>)</span>: <span class="journal-volume">10</span> <span class="page"> Paper 1200801. 11 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fnut.2023.1200801" target="_blank" href="https://doi.org/10.3389/fnut.2023.1200801"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001150436100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001150436100001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="11121" target="_blank" href="http://unipub.lib.uni-corvinus.hu/11121"> 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class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 7 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34496994&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34496994</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.05.05. 16:22 Nyitrai Erzsébet (BCE admin 5) </div> </div></div>