Hungarian Brain Research Program(2017-1.2.1-NKP-2017-00002) Funder: NRDIO
(National Brain Programme 3.0(NAP2022-I-4/2022))
Hungarian Research and Development Fund(131629)
(LSHM-CT-2004-503474)
(2019-2.1.7-ERA-NET-2020-00005) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs
Hivatal
ERA PerMed(ERAPERMED2019-108)
(K 143391) Funder: NRDIO
(TKP2021-EGA-25)
Both early childhood traumatic experiences and current stress increase the risk of
suicidal behaviour, in which immune activation might play a role. Previous research
suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors,
which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in
interaction with early childhood adversities and traumas and recent stressors on lifetime
suicide attempts and current suicide risk markers. Overall, 1644 participants completed
questionnaires assessing childhood adversities, recent negative life events, and provided
information about previous suicide attempts and current suicide risk-related markers,
including thoughts of ending their life, death, and hopelessness. Subjects were genotyped
for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered
into logistic and linear regression models, followed by a clumping procedure to identify
clumps of SNPs with a significant main and interaction effect. We identified two significant
clumps with a main effect on current suicidal ideation with top SNPs rs641940 and
rs1653613. In interaction with childhood trauma, we identified a clump with top SNP
psy_rs11615992 and another clump on hopelessness containing rs78473339 as index SNP.
Our results suggest that P2RX7 variation may mediate the effect of early childhood
adversities and traumas on later emergence of suicide risk.
