https://m2.mtmt.hu/ hun 2026-05-26 17:03 JournalArticle 34496842 VALIDATED true Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa utca 6, Budapest, 1082, Hungary Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine, Szigony utca 43, Budapest, 1083, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, Budapest, 1089, Hungary NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University, Nagyvarad ter 4, Budapest, 1089, Hungary National Centre for Suicide Research and Prevention (NASP), Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Granits väg 4, Solna, 17165, Sweden Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester, Manchester Academic Health Sciences Centre, 46 Grafton Street, Manchester, M13 9NT, United Kingdom Cited By :1 Export Date: 10 September 2024 Correspondence Address: Gonda, X.; Department of Psychiatry and Psychotherapy, Balassa utca 6, Hungary; email: gonda.xenia@semmelweis.hu Chemicals/CAS: P2RX7 protein, human; Receptors, Purinergic P2X7 Funding details: 2017-1.2.1-NKP-2017-00002 Funding details: NAP2022-I-4/2022 Funding details: 131629 Funding details: LSHM-CT-2004-503474 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, 2019-2.1.7-ERA-NET-2020-00005, ERAPERMED2019-108, K 143391, TKP2021-EGA-25 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: This research was funded by the Sixth Framework Program of the European Union, NewMood, LSHM-CT-2004-503474; the Hungarian Academy of Sciences (MTA-SE Neuropsychopharmacology and Neurochemistry Research Group), the Hungarian Brain Research Program (Grant: 2017-1.2.1-NKP-2017-00002); by the Hungarian Brain Research Program 3.0 (NAP2022-I-4/2022); by the National Research, Development and Innovation Office, Hungary (2019-2.1.7-ERA-NET-2020-00005), under the frame of ERA PerMed (ERAPERMED2019-108); by TKP2021-EGA-25, which has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme; by the Hungarian National Research, Development, and Innovation Office (grant number: K 143391); and by the Hungarian Research and Development Fund (grant number 131629). The funding sources had no role in the study design, collection, analysis and interpretation of the data, writing of the report and in the decision to submit the article for publication. 0 false 2026-05-23T11:57:04.101+0000 2025-09-02T08:51:47.180+0000 2024-01-11T13:00:13.083+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 2026-04-08T13:18:15.114+0000 2026-04-08T13:18:15.114+0000 2024-09-10T12:02:51.723+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin true Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kristof, Zsuliet Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 2 865 865 17 2024 Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors, which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in interaction with early childhood adversities and traumas and recent stressors on lifetime suicide attempts and current suicide risk markers. Overall, 1644 participants completed questionnaires assessing childhood adversities, recent negative life events, and provided information about previous suicide attempts and current suicide risk-related markers, including thoughts of ending their life, death, and hopelessness. Subjects were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into logistic and linear regression models, followed by a clumping procedure to identify clumps of SNPs with a significant main and interaction effect. We identified two significant clumps with a main effect on current suicidal ideation with top SNPs rs641940 and rs1653613. In interaction with childhood trauma, we identified a clump with top SNP psy_rs11615992 and another clump on hopelessness containing rs78473339 as index SNP. Our results suggest that P2RX7 variation may mediate the effect of early childhood adversities and traumas on later emergence of suicide risk. 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autype0"> <span class="author-name" mtid="10067777"><a href="/gui2/?type=authors&mode=browse&sel=10067777" target="_blank">Kristof Zsuliet (<span class="authorship-author-name">Kristóf Zsüliet</span> <span class="authorAux-mtmt"> pszichológia, pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Molekuláris Farmakológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067900"><a href="/gui2/?type=authors&mode=browse&sel=10067900" target="_blank">Gal Zsofia (<span class="authorship-author-name">Gál Zsófia</span> <span class="authorAux-mtmt"> neurobiológia, pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075294"><a href="/gui2/?type=authors&mode=browse&sel=10075294" target="_blank">Torok Dora (<span class="authorship-author-name">Török Dóra</span> <span class="authorAux-mtmt"> pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045710"><a href="/gui2/?type=authors&mode=browse&sel=10045710" target="_blank">Eszlari Nora (<span class="authorship-author-name">Eszlári Nóra</span> <span class="authorAux-mtmt"> Pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067899"><a href="/gui2/?type=authors&mode=browse&sel=10067899" target="_blank">Sutori Sara (<span class="authorship-author-name">Sütöri Sára</span> <span class="authorAux-mtmt"> pszichológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh Beata (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Molekuláris Farmakológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anderson Ian M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deakin Bill </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy Gyorgy (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017483"><a href="/gui2/?type=authors&mode=browse&sel=10017483" target="_blank">Juhasz Gabriella (<span class="authorship-author-name">Juhász Gabriella</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xenia ✉ (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34496842" target="_blank">Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">2</span> <span class="page"> Paper 865. 17 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25020865" target="_blank" href="https://doi.org/10.3390/ijms25020865"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="187578" target="_blank" href="http://real.mtak.hu/187578"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001153013100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001153013100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85183332861" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85183332861"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38255938" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38255938&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183332861&doi=10.3390%2Fijms25020865&partnerID=40&md5=0f6d1dea84a1c13b393b1cdd9e548dd9" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183332861&doi=10.3390%2Fijms25020865&partnerID=40&md5=0f6d1dea84a1c13b393b1cdd9e548dd9"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine 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<div class="mtid"><span class="long-pub-mtid">Közlemény: 34496842</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), National Brain Programme(NAP2022-I-4/2022 3.0), Hungarian Research and Development Fund(131629), (LSHM-CT-2004-503474), (2019-2.1.7-ERA-NET-2020-00005) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, ERA PerMed(ERAPERMED2019-108), (K 143391) Támogató: OTKA, (TKP2021-EGA-25) </div> <div class="lastModified">Utolsó módosítás: 2025.09.02. 10:51 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:20 Nemec Évi (MTMT Központi 3, admin) Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa utca 6, Budapest, 1082, Hungary Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine, Szigony utca 43, Budapest, 1083, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, Budapest, 1089, Hungary ...</pre> </div></div>